İstinye Üniversitesi Kurumsal Akademik Arşivi
DSpace@İstinye, İstinye Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Search for non-resonant Higgs boson pair production in final states with leptons, taus, and photons in pp collisions at √s = 13 TeV with the ATLAS detector
(Springer science and business media deutschland GmbH, 2024) Aad, G.; Abbott, B.; Beddall, Andrew John; Çetin, Serkant Ali; Çelebi, Emre; Şimşek, Sinem; Uysal, Zekeriya
A search is presented for non-resonant Higgs boson pair production, targeting the bbZZ, 4V (V = W or Z), VVττ, 4τ, γγVV and γγττ decay channels. Events are categorised based on the multiplicity of light charged leptons (electrons or muons), hadronically decaying tau leptons, and photons. The search is based on a data sample of proton-proton collisions at s = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb−1. No evidence of the signal is found and the observed (expected) upper limit on the cross-section for non-resonant Higgs boson pair production is determined to be 17 (11) times the Standard Model predicted cross-section at 95% confidence level under the background-only hypothesis. The observed (expected) constraints on the HHH coupling modifier, κλ, are determined to be −6.2 < κλ< 11.6 (−4.5 < κλ< 9.6) at 95% confidence level, assuming the Standard Model for the expected limits and that new physics would only affect κλ.
Investigation into drug resistance to cisplatin in cancer stem cell-enriched population in non-small cell lung cancer
(Walter de Gruyter GmbH, 2025) Dere, Egemen; Akgün, Oǧuzhan; Aztopal, Nazllhan; Ulukaya, Engin
understanding drug resistance in cancer is of importance in treatment. Cancer stem cells are main factor for drug resistance. Therefore, the possible gene/gene interactions/proteins were explored in our study using a cancer stem cell-enriched population (H1299/S) derived from a parental non-small cell lung cancer cell line (H1299/P). response to cisplatin, which is the main drug for the treatment of lung cancer, was evaluated with the Adenosine triphosphate (ATP) viability test. As a result of the gene expression analysis, while 14 genes were not evaluated, expression profiles were obtained for 37 genes out of 51 genes. By the drug-protein interaction analyses, Topoisomerase I (TOPI), Topoisomerase 2 alpha (TOP2A), Topoisomerase 2 beta (TOP2B), Cyclin-dependent kinases 4 (CDK4), Cyclin-dependent kinases 6 (CDK6), ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily C member 1 (ABCC1), ATP binding cassette subfamily C member 3 (ABCC3), B-cell leukemia/lymphoma 2 (BCL2), Poly (ADP-ribose) polymerase 1 (PARP1), Breast cancer gene 1 (BRCA1) and Cyclin dependent kinase inhibitor 1A (CDKN1A) genes and protein products were statistically significantly found to be in association with drug resistance. in bioinformatics analyses, it was observed that 13 pathways were affected due to expression changes and 12 genes related to these pathways were determined to activate multidrug resistance mechanisms. platinum-based drugs, as well as a broad range of other agents including topoisomerase and PARP1 inhibitors, and anthracyclines, have been shown to potentially possess multiple drug resistance. © 2024 bei den Autorinnen und Autoren, publiziert von Walter de Gruyter GmbH, Berlin/Boston 2024.
Investigation of Cable Line Heat Mode Parameters in Power Supply Systems
(Institute of Electrical and Electronics Engineers Inc., 2024) Valtchev, Stanimir; Miceli, Rosario; Gracheva, Elena Ivanovna; Petrov, Almaz Radikovich; Tsitson, Ivan Ivanovich; Çolak, İlhami
The paper develops regression models of dependences of the estimated service life of cable line insulation on the load factor in various operating conditions. The study of thermal modes using approximation functions of the obtained results is carried out. The temperature parameters of the cable line with different types of insulation have been obtained. The results can be used to clarify the temperature modes of cable lines when selecting their cross-sections at the stage of design of electrical engineering systems. © 2024 IEEE.
Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair under Combined Spinal Epidural Anesthesia Versus General Anesthesia
(Lippincott Williams and Wilkins, 2024) Dönmez, Turgut; Tülübaş, Evrim Kucur; Bostancı, İpek
Background: Inguinal hernia repair is one of the most frequently used elective surgical operations in the world. General anesthesia (GA) has risks and routine postoperative complications, such as nausea, vomiting, throat irritation, and postoperative pain. Regional anesthesia (RA) has many advantages over GA, such as faster recovery, less postoperative pain, nausea, and vomiting, and less hemodynamic compromise. We aimed to investigate the efficacy and safety of combined spinal and epidural anesthesia (CSEA) in preventing shoulder pain in patients undergoing totally extraperitoneal herniorrhaphy (TEP). Materials and Methods: The files of patients who had undergone the TEP method under GA and CSEA due to inguinal hernia between April 2020 and November 2021 at the Bakirköy Dr. Sadi Konuk Training and Research Hospital were reviewed retrospectively. Results: A total of 81 patients were included in the study. The number of patients operated on GA (group 1) was 40, and the number of patients operated under CSEA (group 2) was 41. There was no significant difference in the demographic characteristics of the patients. The surgical time was 42.9 and 42.5 minutes in groups 1 and 2, respectively (P=0.970). The mean operative time was recorded as 60.1 and 80.2 minutes in groups 1 and 2, respectively, and it was statistically significantly shorter in group 1 (P<0.001). A peritoneal tear was seen in 18 patients (43.90%) in the GA group and 16 patients (40%) in the CSEA group, but no significant difference was found between the groups (P=0.823). Mild shoulder pain that did not require intervention was observed in 1 patient (2.5%) in the CSEA group. In group 2, the VAS scores at all times and the need for postoperative analgesia were statistically significantly lower (P<0.001). In terms of anesthesia complications, headache was not observed in group 1, while it was seen in 6 (15%) patients in group 2 (P=0.012) Conclusions: In laparoscopic TEP surgeries, CSEA may be an alternative anesthesia method to GA anesthesia due to the low VAS score, less need for analgesia, and fewer postoperative pulmonary complications. © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Learning theory
(Elsevier, 2024) Pour Haji Kazem, Ali Asghar
This chapter addresses fundamental aspects of learning theory, its ethical implications in model development and deployment, its integration with decision-making processes, and future directions. The introduction highlights learning theory's role in bridging data and informed choices, while ethical considerations underscore the need to address bias, transparency, and societal impact. The interplay between learning theory and decision-making is explored, enabling systems to navigate uncertainty. Looking ahead, the evolution of learning theory is expected to encompass explainable AI, neuroscience influences, ethical considerations, and integration with emerging technologies, promising transformative advancements across various domains. © 2024 Elsevier Inc. All rights reserved.
