İstinye Üniversitesi Kurumsal Akademik Arşivi
DSpace@İstinye, İstinye Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Combination of searches for resonant higgs boson pair production using 𝑝𝑝 collisions at √𝑠=13 TeV with the ATLAS detector
(American Physical Society, 2024) Filmer, E.K.; Grant, C.M.; Jackson, P; Beddal, Andrew John; Çetin, Serkant Ali; Öztürk, Sertaç; Şimşek, Sinem; Uysal, Zekeriya
A combination of searches for a new resonance decaying into a Higgs boson pair is presented, using up to Formula Presented of Formula Presented collision data at Formula Presented recorded with the ATLAS detector at the LHC. The combination includes searches performed in three decay channels: Formula Presented, Formula Presented, and Formula Presented. No excess above the expected Standard Model background is observed and upper limits are set at the 95% confidence level on the production cross section of Higgs boson pairs originating from the decay of a narrow scalar resonance with mass in the range 251 GeV-5 TeV. The observed (expected) limits are in the range 0.96-600 fb (1.2-390 fb). The limits are interpreted in the type-I two-Higgs-doublet model and the minimal supersymmetric standard model, and constrain parameter space not previously excluded by other searches. © 2024 CERN, for the ATLAS Collaboration.
Observation of an excess of dicharmonium events in the four-muon final state with the ATLAS detector
(Amer Physical Soc, 2023) Aad, Georges; Abbott, Braden; Abeling, Kira; Beddall, Andrew John; Çetin, Serkant Ali; Öztürk, Sertaç; Şimşek, Sinem
A search is made for potential ccc over bar c over bar tetraquarks decaying into a pair of charmonium states in the four ffiffi muon final state using proton-proton collision data at p s = 13 TeV, corresponding to an integrated luminosity of 140 fb-1 recorded by the ATLAS experiment at LHC. Two decay channels, J lig +J lig -4 mu and J lig + ig(2S) -4 mu, are studied. Backgrounds are estimated based on a hybrid approach involving Monte Carlo simulations and data-driven methods. Statistically significant excesses with respect to backgrounds dominated by the single parton scattering are seen in the di-J lig channel consistent with a narrow resonance at 6.9 GeV and a broader structure at lower mass. A statistically significant excess is also seen in the J lig + ig(2S) channel. The fitted masses and decay widths of the structures are reported.
How reliable is the high-volume definition in prostate cancer patients: the potential game-changing role of PSMA
(Lippincott Williams & Wilkins, 2023) Guven, Osman; Karyagar, Savas; Arici, Serdar; Ozulker, Tamer; Can, Orcun
PurposeTo evaluate whether metabolic and volumetric data from Ga-68-PSMA PET/CT performed during staging of de-novo high-volume mCSPC patients who received docetaxel could be used to predict survival. MethodsForty-two de-novo high-volume mCSPC patients, who received ADT + Docetaxel and underwent Ga-68-PSMA PET/CT for staging, were included in the study. The association between patients' pathological data, all PSA measurements, treatments they received, the data obtained from Ga-68-PSMA PET/CT and progression-free and overall survival were examined. ResultsIn the multivariate analysis, PSMA-TV (primary) and PSMA-TV (WB) variables were shown to be independent negative predictors of overall survival. For the threshold value of 19.91 cm(3) obtained for PSMA-TV (primary), HR was calculated as 6.31, the 95% confidence interval (CI): 1.01-39.18, P = 0.048. For the threshold value of 1226.5 cm(3) obtained for PSMA-TV (WB) variable, HR was calculated as 58.62, the 95% CI: 2.55-1344.43, P = 0.011. In our study, SUVmax (WB) variable was found to be an independent and negative predictor of progression-free survival. For the determined threshold value of 17.74, HR was calculated as 16.24, 95% CI: 1.18-22.76, P = 0.037. ConclusionMetabolic and volumetric data obtained from Ga-68-PSMA PET/CT can be used to predict survival in de-novo high-volume mCSPC. Our results show that in ADT + Docetaxel receiving patients, a subgroup with higher PSMA-TV (WB) values have a significantly worse prognosis. This situation suggests that the high-volume disease definition in the literature may be insufficient for this group, and that Ga-68-PSMA PET/CT can play an essential role in demonstrating the heterogeneity within the group.
INFECTIVITY AND REPLICATION INHIBITION EFFECT OF 5-FLUOROURACIL ON HERPES SIMPLEX VIRUS TYPE-1 ASSOCIATED WITH MUTATIONS IN THYMIDINE KINASE GENE
(Soc Stiinte Farmaceutice Romania, 2022) Taskin, Mehmet Hakan; Kurucay, Hanne Nur; Kadi, Hamza; Tamer, Cuneyt; Ozan, Emre; Muftuoglu, Bahadir; Albayrak, Harun
Two pandemics over the first two decades of the 21st century have shown that viruses with epidemic and pandemic potentials constitute a major threat to human health due to the lack of effective antivirals. Developing new antivirals and treatment strategies is also as important as vaccines play a crucial role in the first line of preventing viral infections. Using base analogues that directly target viruses and understanding their action mechanisms can present essential alternative treatment strategies to combat viral diseases. The current study investigated the effects of a base analogue on herpes simplex virus type1 (HSV-1) replication in a cell culture system using the pyrimidine analogue 5-fluorouracil (FU). After that, the full-length UL-23 gene encoding thymidine kinase (TK) of HSV-1 was sequenced to detect induced mutations. The results showed a diminishing viral titre and viral load at 2 logs and 663 times, respectively, at the end of 10 consecutive passages with 5-FU. Furthermore, two mutations substitute amino acids in the non-conserved region of the TK gene, which confers drug resistance, were also identified. The current research is a feasibility study to investigate the antiviral effects of 5-FU on DNA viruses and has reinforced the fact that 5-FU can have an antiviral effect on HSV-1. However, drug resistance for viruses should not be underestimated.
Effect of embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii
(Springer, 2023) Ahmed, Usman; Ong, Seng-Kai; Khan, Khalid Mohammed; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed; Shaikh, Mohd Farooq; Alawfi, Bader Saleem
Acanthamoeba castellanii is the causative agent of fatal encephalitis and blinding keratitis. Current therapies remain a challenge, hence there is a need to search for new therapeutics. Here, we tested embelin (EMB) and silver nanoparticles doped with embelin (EMB-AgNPs) against A. castellanii. Using amoebicidal assays, the results revealed that both compounds inhibited the viability of Acanthamoeba, having an IC50 of 27.16 +/- 0.63 and 13.63 +/- 1.08 mu M, respectively, while causing minimal cytotoxicity against HaCaT cells in vitro. The findings suggest that both samples induced apoptosis through the mitochondria-mediated pathway. Differentially expressed genes analysis showed that 652 genes were uniquely expressed in treated versus untreated cells, out of which 191 were significantly regulated in the negative control vs. conjugate. Combining the analysis, seven genes (ARIH1, RAP1, H3, SDR16C5, GST, SRX1, and PFN) were highlighted as the most significant (Log2 (FC) value +/- 4) for the molecular mode of action in vitro. The KEGG analysis linked most of the genes to apoptosis, the oxidative stress signaling pathway, cytochrome P450, Rap1, and the oxytocin signaling pathways. In summary, this study provides a thorough framework for developing therapeutic agents against microbial infections using EMB and EMB-AgNPs.
