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  • Küçük Resim
    Öğe
    Analysis of adnexal masses which are operated in gynecologic oncology clinic
    (2018) Erdem, Baki; Peker, Nuri; Seyhan, Niyazi Alper; Aşocıoğlu, Osman; Temel Yüksel, İlkbal; Ülker, Volkan; Akbayır, Özgür
    Objective: Abnormal adnexal masses are a common gynecologic problem that affects women of all ages. Although many of these masses are benign, the primary aim of diagnostic evaluation is to exclude malignancy. In this trial, we aimed to analyze adnexal masses that are referred and operated in our gynecologic oncology clinic. Methods: A total of 1,152 patients operated in our clinic due to suspicious malignancy between 2004 and 2017 were included in this trial. Patient data from the database of the gynecologic oncology clinic were analyzed retrospectively. Results: Among all included patients, benign pathological results were determined in 529 (45.92%) patients, whereas malignant and borderline tumors were determined in 505 (43.83%) patients and 118 (10.24%) patients, respectively. The median cancer antigen 125 level in the malignancy group was 150 (7-15,554) IU/mL, whereas that in the benign and borderline groups, it was 19 and 29 IU/ mL, respectively. Conclusion: Many benign masses imitate ovarian cancer. Although some of them can be separated, preoperative careful examination and histological examination are the established diagnostic procedures.
  • Küçük Resim
    Öğe
    Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?
    (Elsevier Science Bv, 2018) Erdem, Baki; Aşıcıoğlu, Osman; Seyhan, Niyazi Alper; Peker, Nuri; Ülker, Volkan; Akbayır, Özgür
    Background: This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. Materials and methods: A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2 cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk. Results: In final pathology, 57 (25.1%) patients had endometrial cancer and 7 (3%) patients had high-risk cancer. Overall analysis of FS/PS agreement yielded a Cohen's Kappa (K) coefficient of 0.420 (moderate agreement). There was moderate (K=0.526) agreement between FS and PS in detecting tumor grade, and good agreement (K=0.653) in evaluation of myometrial invasion. Conclusion: High-risk endometrial cancer can coexist with AEH. It should be remembered that despite pre-operative and FS examinations, these high-risk tumors can be overlooked until final pathology.