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    Energy deposition responses, transmission factors, and radiation interaction properties of some antibiotics: A critical assessment for substantial molecular alterations as a function of radiation exposure
    (Pergamon-Elsevier Science Ltd, 2024) Almansoori, Asma; Almisned, Ghada; Sen Baykal, Duygu; Kilic, Ceyda Sibel; Tekin, H. O.
    This study addresses the underexplored area of radiation interaction properties of antibiotics and their implications for stability, efficacy, and structural integrity. Focusing on a range of antibiotics classified by the United Arab Emirates National AMR Surveillance system, the research evaluates key metrics such as attenuation coefficients, effective electron density, exposure buildup factor, and photon transmission factors. Utilizing advanced MCNPX Monte Carlo simulation, we observed varied interaction patterns among different antibiotics, with significant findings on their photon interaction characteristics. The study highlights the potential molecular changes in antibiotics due to radiation exposure, emphasizing the importance of such research in fields from medical radiography to space exploration. Results indicate that radiation exposure can significantly affect antibiotic properties, underscoring the need for careful evaluation of drugs in radiation-rich environments to ensure their effectiveness and safety.
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    Evaluating deposited radiation energy amount and collision quantities of small-molecule radiosensitizers through Monte Carlo simulations
    (Cell press, 2024) Almisned, Ghada; Kılıç, Ceyda Sibel; Almansoori, Asma; Mesbahi, A.; Hamad, Mawieh; Tekin, Hüseyin Ozan
    This study investigates the photon interaction mechanism of various small molecule radiosensitizers, including Hydrogen Peroxide, Nimorazole, 5-Fluorouracil, NVX-108, and others, using the MCNP 6.3 Monte Carlo simulation code. The simulations focused on quantifying the linear attenuation coefficients, mean free path, and accumulation factors of these radiosensitizers, as well as their interactions in a simulated spherical water phantom irradiated with a 100 keV mono-energetic X-ray source. Our findings reveal significant variations in deposited energy, collision events, and mean free path among the radiosensitizers, indicating different efficacy levels in enhancing radiation therapy. Notably, NVX-108 demonstrated the highest energy deposition, suggesting its potential as a highly effective radiosensitizer. The study also examined the individual attenuation properties of these radiosensitizers against energetic photons, with NVX-108 showing the highest attenuation coefficient and a shorter mean free path, further supporting its superior potential in effective radiosensitization. It can be concluded that NVX-108 has higher interaction tendency with the energetic photons comparing other small-molecules under investigation.