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    Assessment of sacubitril/valsartan effects on left ventricular dynamics using 3D echocardiography and 3D strain in heart failure with reduced ejection fraction patients
    (MedGen, 2021) Kemaloğlu Öz, Tuğba; Abdelnabi, Mahmoud; Fiore, Corrado; Almaghraby, Abdallah; Cihan, Deniz; Babazade, Nigar
    BACKGROUND: Three-dimensional (3D) echocardiography and 3D strain parameters have been used for a comprehensive quantitative assessment of left ventricular (LV) myocardial dynamics. So far, there are no data on sacubitril/valsartan effects on cardiac functions and LV reverse remodeling using 3D echocardiography. This study aimed to evaluate the effects of sacubitril/valsartan on the LV functions using two-dimensional (2D) echocardiography, 3D echocardiography, and the 3D strain parameters. METHODS: A single-center prospective cohort study which included 100 heart failure with reduced ejection fraction (HFrEF) patients with guidelines-approved indications for sacubitril/valsartan treatment. Patients received a short course (3-month) of sacubitril/valsartan. 3-month follow-up 2D, 3D echocardiographic parameters, and 3D strain were compared to baseline parameters. RESULTS: The results of the study revealed a significant improvement in left ventricular dynamic functions at 3-month follow-up with an improvement in left ventricular systolic function (mean left ventricular ejection fraction (LVEF) increased from 27.65 ± 4.98% to 32.89 ± 6.03%, P<0.001). Comparison of HFrEF patients with ischemic and non-ischemic etiologies showed that echocardiographic parameters significantly improved in both groups after 3 months of sacubitril/valsartan treatment. There was no statistically significant difference between both groups regarding echocardiographic parameters at baseline and 3-month follow-up. CONCLUSIONS: In a single-center prospective observational cohort study evaluating the effects of short-term (3-month course) sacubitril/valsartan treatment on LV dynamics assessed by 3D echocardiography and 3D strain, sacubitril/valsartan was associated with a significant improvement of LV systolic functions and reverse remodeling effects in both ischemic and non-ischemic HFrEF patients.
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    Coronavirus disease 2019 and catheterisation laboratory considerations: "looking for essentials"
    (2020) Naqvi, Syed Haseeb Raza; Fatima, Madiha; Gerges, Fady; Moscatelli, Sara; Kemaloğlu Öz, Tuğba; Kotlar, Irina; Babazade, Nigar; Hashemi , Arash; Almaghraby , Abdallah Mostafa
    The current coronavirus disease 2019 (COVID-19) outbreak is a significant health crisis that impacts every healthcare system worldwide, and has led to a dramatic change in dealing with different diseases during the pandemic. Interventional cardiologists are frontline workers who deal with many cardiovascular emergencies, either in patients with proven COVID-19 or in suspected cases. Many heart associations worldwide are currently setting appropriate recommendations for the management of emergency cardiac interventions. In this expert opinion, the authors highlight the essential requirements in the cardiac catheterisation laboratory during the COVID-19 pandemic.
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    International consensus statement on challenges for women in cardiovascular practice and research in the COVID-19 era
    (Minerva Medical, 2022) Kemaloğlu Öz, Tuğba; Cader, F. Aaysha; Dakhil, Zainab A.; Parapid, Biljana; Kadavath, Sabeeda; Bond, Rachel; Chieffo, Alaide; Gimelli, Alessia; Mihailidou, Anastasia S.; Ramu, Bhavadharini; Cavarretta, Elena; Michos, Erin D.; Kaya, Esra; Buchanan, Louise; Patil, Mansi; Aste, Milena; Alasnag, Mirvat; Babazade, Nigar; Burgess, Sonya; Manzo-Silberman, Stephane; Paradies, Valeria; Thamman, Ritu
    The challenges to academic and professional development and career advancement of women in cardiology (WIC), imposed by the pandemic, not only impinge the female cardiologists' "leaky pipeline" but also make the "leakiness" more obvious. This consensus document aims to highlight the pandemic challenges WIC face, raise awareness of the gender equity gap, and propose mitigating actionable solutions derived from the data and experiences of an international group of female cardiovascular clinicians and researchers. This changing landscape has led to the need for highly specialized cardiologists who may have additional training in critical care, imaging, advanced heart failure, or interventional cardiology. Although women account for most medical school graduates, the number of WIC, particularly in mentioned sub-specialties, remains low. Moreover, women have been more affected by systemic issues within these challenging work environments, limiting their professional progression, career advancement, and economic potential. Therefore, it is imperative that tangible action points be noted and undertaken to ensure the representation of women in leadership, advocacy, and decision-making, and increase diversity in academia. Strategies to mitigate the negative impacts of the pandemic need to be taken during this COVID-19 pandemic to ensure WIC have a place in the field of Cardiology.
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    Women empowerment in cardiology: the pink international young academy of cardiology
    (Elsevier Inc., 2020) Moscatelli, Sara; Kotlar, Irina; Babazade, Nigar; Sabatino, Jolanda; Kemaloğlu Öz, Tuğba
    It has been widely discussed that women across the world face multiple challenges when pursuing their career of choice. Medicine, as a competitive and evolving field of science, demands great sacrifice and extreme commitment. Cardiology puts extreme physical and psychological pressure on physicians, often testing the final limits of their endurance. For a variety of reasons, cardiology attracts women less than other subspecialties.