Yazar "Baysan, Mehmet" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Modulation of YAP1 expression and other related signaling pathways in HepG2 cells by extracellular matrix, contact inhibition and cell density
    (WILEY, 2020) Aktaş, Ranan, Sr.; Akbulut, Zeynep; Maraş, Hatice, Jr.; Çakıl, Yaprak Dönmez; Kayalı, Damla; Karagöz Köroğlu, Ayça; Sitar, Mustafa Erinç; Kısakol, Batuhan; Baysan, Mehmet
    Background: Hippo-YAP pathway is a key modulator in liver development, egeneration and the metabolism . Cell density, cell contact, the actin cytoskeleton, and extracellular matrix (ECM) composition have been shown to be involved in regulation of this pathway . The intervention of this pathway in hepatocellular carcinoma remains a central focus . The study aimed to examine how YAP1 integrate mechanical cues with the response to signal transduction pathways and to multiple aspects of cell behavior, proliferation, protein/lipid secretion, apoptosis/necrosis, adhesion, and stemness .