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Öğe Are the anxiety levels of pediatric hematology-oncology patients different from healthy peers during the COVID-19 outbreak?(2020) Çakıroğlu, Süleyman; Yeltekin, Ceren; Fışgın, Tunç; Öner, Özlem B.; Adaklı Aksoy, Başak; Bozkurt, CeyhunThe COVID-19 outbreak has caused anxiety among children with hematology-oncology disease and their families, as it has in every segment of society. In this study, we aimed to detect the anxiety levels of children with hematologic or oncologic disease and of their parents after the COVID-19 outbreak. The sample consisted of 15 patients aged 12 to 18 years receiving treatment in the Pediatric Hematology and Oncology Unit in Altinbaş University Medical Faculty Bahçelievler Medikalpark Hospital and 33 parents of the same unit patients aged between 6 and 18, and their 35 healthy peers and their parents. The State-Trait Anxiety Inventory was applied to participant children and their parents to evaluate their general anxiety and pandemic-related anxiety levels. Children with a hematology-oncology disease and their families were compared with healthy peers and their families. No significant difference was observed for pandemic-related anxiety levels (P>0.05). Both parent groups exhibited higher anxiety levels with regard to the pandemic than did their children (P<0.05). Children with hematology-oncology disease reported significantly higher trait anxiety levels when compared with healthy peers (P=0.01). The families of children who had not received stem cell transplantation had higher state and trait anxiety scores than the families of children who had received the transplantation (P<0.05). Even though they were in the high-risk group, children with a hematology-oncology disease and their families had pandemic-related anxiety levels comparable to those of healthy peers and their families.Öğe Assessment of serum vitamin D in pediatric hematopoietic stem cell transplantation patients and its relation with complications(Nature Publishing Group, 2018) Karakaş, Zeynep; Aydoğdu, Selime; Yılmaz, Yasin; Bozkurt, Ceyhun; Aykanat, Alper; Fışgın, TunçRecently, evaluation of serum vitamin D level in pediatric hematopoietic stem cell transplantation (HSCT) patients gained popularity, as there is close relation with development of GVHD and complications. Our aim was to assess the serum vitamin D level and its relation with GVHD and complications such as graft failure in HSCT patients.Öğe Beta globin mutations in Turkish, northern Iraqi and albanian patients with beta thalassemia major(Pagepress Publ, 2018) Hançer, Veysel Sabri; Fışgın, Tunç; Büyükdoğan, Murat; Bozkurt, Ceyhun; Lako, SotiraqThe mutation detection of beta thalassemia is absolutely necessary for molecular diagnosis, as well as any genetic epidemiological study. The b globin gene has 3 exons and 2 introns, involved in beta-thalassemic pathogenesis. The study aim of the study is to characterize the spectrum of b globin gene mutations in 136 Turkish, Northern Iraqi and Albanian pediatric beta thalassemia major patients. After genomic DNA extraction from venous blood and amplification of the target DNA regions with PCR, genotyping was achieved by Sanger based DNA sequencing. The IVSI-110 G>A mutation was the most frequent allele in the Turkish and Albanian patients. In Northern Iraqi patients IVSI-1 G>A was is the most frequent. There are two mutations are firstly reported for Albania [c.*111 A>G 3' UTR (rs63751128) and c.113 G>A (p.Trp38Ter, p.W38*) (rs35887507)] with this study. These findings may be of value for genetic counseling, premarital diagnosis, prenatal diagnosis and prevention programs.Öğe Biallelic form of a known CD3E mutation in a patient with severe combined immunodeficiency(Springer/Plenum Publishers, 2020) Erman, Baran; Fırtına, Sinem; Fışgın, Tunç; Bozkurt, Ceyhun; Erol Çipe, FundaT cell receptor (TCR) complex consists of ?? or ?? TCR chains in combination with four CD3 subunits, CD3?, CD3?, CD3?, and CD? [1]. This complex is required for thymocyte development and the initiation of T cell-mediated adaptive immune responses. Although TCR chains bind antigenic peptides presented by MHC molecules, the CD3 subunits provide transduction of signals into the cytosol for the activation and differentiation of T lymphocytes [2]. CD3 deficiencies can cause a rare form of severe combined immunodeficiency (SCID). Although CD3?, CD3?, and CD? mutations usually result in a T- B+ +NK+ SCID phenotype, CD3? deficiency leads to a milder phenotype with autoimmunity [3]. Only 2% of patients with SCID have TCR defects [3]. The T cell antigen receptor epsilon subunit (CD3E) gene is located at 11q23.3 and has been associated with autosomal recessive SCID [4]. Only a few mutations of the CD3E gene have been identified so far [4–8]. Here, we identified the biallelic form of a known CD3E mutation in a patient with a severe T- B+ NK+ phenotypeÖğe CMV-specific T-Cells for Treatment of CMV infection after hematopoietic stem cell transplantation in a pediatric case: First application in Turkey(Galenos Yayincilik, 2020) Celilova, Sevil; Töret, Ersin; Adaklı Aksoy, Başak; Ovalı, Ercüment; Bozkurt, CeyhunCytomegalovirus (CMV) infection is still a major complication after allogeneic hematopoietic stem cell transplantation (HSCT) [1,2]. Unfortunately, prolonged antiviral treatment of CMV infection causes a delayed CMV-specific immune reconstitution. At this point, adoptive immunotherapy by CMV-specific T-cells can control CMV infection or provide immune reconstructionÖğe Comparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major(Nature Publishing Group, 2019) Aydoğdu, Selime; Mergen, Azize; Adaklı Aksoy, Başak; Çokluk, Mila N.; Dikme, Gürcan; Erol Cipe, Funda; Fışgın, Tunç; Bozkurt, CeyhunAlthough there have been significant improvements with conventional therapies in beta thalassemia major, hematopoietic stem cell transplantation is only curative therapy. Related donors are preferred to diminish transplant risks. In lack of identical related donor, identical unrelated donors are second best choice. In this study, thalassemia major patients transplanted from unrelated donors (MUD) were compared with thalassemic patients transplanted from relative donor (MRD) retrospectively.Öğe Comparison of hematopoietic stem cell transplantation results in patients with ?-thalassemia major from three different graft types(Taylor & Francis Online, 2021) Aydoğdu, Selime; Töret, Ersin; Adaklı Aksoy, Başak; Aydın, Muhammed Fatih; Erol Cipe, Funda; Bozkurt, Ceyhun; Fışgın, TunçAllogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for ?-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) for about 70.0% of patients from 2000 onwards. The chance of finding a non-sibling fully matched family donors is higher in some ethnic groups in which consanguineous marriages are common. We have studied and compared transplant complications and outcomes in different graft types (sibling, non-sibling family and unrelated). The non-sibling matched family donor (MFD) group consisted of four mothers, three fathers, five cousins, one paternal uncle and one paternal aunt. There was no significant difference in the mean transfused CD34+ cells, engraftment, median days of neutrophil and platelet recovery were achieved (p?>?0.05). The distribution of postttransplant complication did not show any significant difference between groups (p?>?0.05). In univariate analysis and multivarite analyses, age, gender, Pesaro risk group (I-II vs. III) and ABO incompatibilty demonstrated a significant difference in disease free survival (p?Öğe Comparison of turkish stem cell coordination center (TURKOK) with Istanbul university bone marrow bank (TRIS); A single center experience in match unrelated donors(Nature Publishing Group, 2019) Mergen, Azize; Aydoğdu, Selime; Adaklı Aksoy, Başak; Savcı, Yunus Emre; Dikme, Gürcan; Erol Cipe, Funda; Bozkurt, Ceyhun; Fışgın, TunçMatch family donors are the preferable options in allogenic stem cell transplant. However, in the absence of donor relatives match unrelated donors have been an option. In this study, the donor screening, transplant preparation phases of Turkish Stem Cell Coordination Center (TURKOK) and the İstanbul University Bone Marrow Bank (TRIS), were compared.Öğe Could the COVID-19 infection have a better prognosis than expected in pediatric hematology oncology and bone marrow transplant patients?(AVES, 2021) Öner, Özlem Başoğlu; Aksoy, Başak Adaklı; Yaman, Ayhan; Sütçü, Murat; Erol Çipe, Funda; Atça, Ali Önder; Bozkurt, Ceyhun; Fışgın, TunçCoronavirus disease 2019 (COVID-19) is a pandemic that spread rapidly worldwide (1). So far, very few reports concerning the impact of COVID-19 among patients with pediatric hematologic-oncologic diseases are available (2). We aimed to describe the clinical features, prevalence, treatments, and outcomes in the COVID-19 patient population.Öğe COVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group(Wiley, 2024) Bozkurt, Ceyhun; Hazar, Volkan; Malbora, Baris; Kupesiz, Alphan; Aygunes, Utku; Fisgin, Tunc; Karakukcu, MusaBackgroundData on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited.ObjectivesThe study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID-19 infection.MethodIn this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID-19 between March 2020 and August 2022.ResultsThe median time from HSCT to COVID-19 infection was 209.0 days (IQR, 111.7-340.8; range, 0-3845 days). The most common clinical manifestation was fever (58.7%). While most patients (78.8%) had asymptomatic/mild disease, the disease severity was moderate in 9.2% and severe and critical in 4.4% and 7.6%, respectively. The overall mortality was 10.9% (n: 20). Deaths were attributable to COVID-19 in nine (4.9%) patients. Multivariate analysis revealed that lower respiratory tract disease (LRTD) (OR, 23.20, p: .001) and lymphopenia at diagnosis (OR, 5.21, p: .006) were risk factors for ICU admission and that HSCT from a mismatched donor (OR, 54.04, p: .028), multisystem inflammatory syndrome in children (MIS-C) (OR, 31.07, p: .003), and LRTD (OR, 10.11, p: .035) were associated with a higher risk for COVID-19-related mortality.ConclusionWhile COVID-19 is mostly asymptomatic or mild in pediatric transplant recipients, it can cause ICU admission in those with LRTD or lymphopenia at diagnosis and may be more fatal in those who are transplanted from a mismatched donor and those who develop MIS-C or LRTD. COVID-19 in children following HSCT is frequently asymptomatic/mild. Nonetheless, 12% of patients have such severe disease that they need intensive care. Adverse outcomes are expected in mismatched HSCT, lymphopenia, LRTD, and MIS-C.imageÖğe Cross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives(Scientific and Technical Research Council of Turkey, 2020) İncesoy Özdemir, Sonay; Taçyıldız, Nurdan; Varan, Ali; Kebudi, Rejin; Zülfikar, Osman Bülent; Celkan, Tülin Tiraje; Şahin, Gürses; Çorapçıoğlu, Funda Vesile; Keskin Yıldırım, Zuhal; Pınarlı, Faruk Güçlü; Olgun, Hatice Nur; Sarı, Neriman; Dağdemir, Ayhan; Özyörük, Derya; Eren, Tuba; Çakır, Fatma Betül; Adaklı Aksoy, Başak; Bozkurt, Ceyhun; Güler, Elif; Özgüven, Ali Aykan; Erbey, Mehmet Fatih; Berber Hamamcı, Melda; Dinçaslan, Handan; Ünal, Emel; Kantar, MehmetAim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors.Öğe Different kinetics and risk factors for isolated extramedullary relapse after allogeneic hematopoietic stem cell transplantation in children with acute leukemia(Elsevier, 2021) Hazar, Volkan; Öztürk, Gülyüz; Yalçın, Koray; Uygun, Vedat; Aksoylar, Serap; Bozkurt, CeyhunRelapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most frequent cause of posttransplant mortality. Isolated extramedullary relapse (iEMR) after HSCT is relatively rare and not well characterized, particularly in pediatric patients. We retrospectively analyzed 1527 consecutive pediatric patients with acute leukemia after allo-HSCT to study the incidence, risk factors and outcome of iEMR compared to systemic relapse. The 5-year cumulative incidence of systemic relapse ?either bone morrow (BM) only or combined with EMR? and iEMR was 24.8% and 5.5%, respectively. The onset of relapse after allo-HSCT was significantly longer in EM sites than in BM sites (7.19 and 5.58 months, respectively; p: 0.013). CR2+/active disease at transplantation (HR, 3.1, p<0001) and prior extramedullary disease (HR, 2.3; p: 0.007) were independent risk factors for iEMR. Chronic graft-versus-host disease (GVHD) reduced the risk of systemic relapse (HR, 0.5; p: 0.043) but did not protect against iEMR. The prognosis of patients who developed iEMR remained poor but was slightly better than that of patients who developed systemic relapse (3-year overall survival, 16.5% vs 15.3%, p: 0.089). Patients experiencing their first systemic relapse continued to have further systemic relapse, but only a minority progressed to iEMR, while those experiencing their iEMR at first relapse developed further systemic and isolated extramedullary relapses with approximately similar frequencies. Second iEMR was more common after the first iEMR than after the first systemic relapse (58.8% vs 13.0%, p: 0.001) and was associated with a poor outcome. iEMR has a poor prognosis, particularly after the 2nd relapse, and effective strategies are needed to improve outcomes.Öğe Donor lymphocyte infusion administrations after allogeneic stem cell transplantations in pediatrics: a single center experience(Nature Publishing Group, 2019) Aydoğdu, Selime; Mergen, Azize; Adaklı Aksoy, Başak; Akbay, Hazal S.; Erol Cipe, Funda; Dikme, Gürcan; Fışgın, Tunç; Bozkurt, CeyhunLoss of chimerism is one of the major problems after allogeneic stem cell transplantation(SCT). Donor- lymphocyte infusions(DLI) are used as a treatment after taper or stopping immunosuppression. In this study, DLI experience in 20 patients with loss of chimerism after SCT due to various benign and malign hematological diseases was presented.Öğe Economic and psychosocial problems experienced by pediatric with cancer patients and their families during the treatment and follow-up process(Turkish Pediatrics Assoc, 2019) Bozkurt, Ceyhun; Uğurlu, Zilan; Tanyıldız, Hikmet Gülşah; Yeşil, Şule; Kiraz, Haşim; Toprak, Şule; Yüksek, Nazmiye; Şahin, Gürses; Ertem, UlyaAmaç: Dr. Sami Ulus Kadın Doğum ve Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi Çocuk Onkoloji Kliniği’nde tedavi edilmiş kanserli çocuk hastaların ve yakınlarının bu süreçte karşılaştıkları psikososyal ve ekonomik sorunları belirlemek. Gereç ve Yöntemler: Dr. Sami Ulus Çocuk Sağlığı ve Hastalıkları Hastanesi Çocuk Onkoloji Kliniği’nde 1996–2015 yılları arasında tedavi görmüş ve şu anda hastalıksız olarak izlemde olan toplam 100 hasta ve yakını ile görüşülerek yaşadıkları psikososyal ve ekonomik sorunlara ilişkin anket soruları yönlendirildi. Bulgular: Hastalarımızın çoğu Ankara dışı illerden gelmekte idi. Hasta ailelerinin %80’inin ortalama aylık gelirinin ailenin gereksinimlerini karşılama düzeyinin altında olduğu ve sadece %16’sının ek geliri olduğu saptandı. Hasta grubunda ailelerimizin %93’ü ek ekonomik destek almışlardı. Yirmi beş aile (%25) tedavi süresince sahip oldukları bazı mal varlıklarını satmak zorunda kalmıştı. Kırk dokuz (%49) aile tanıdık ve akrabalarından borç almıştı ya da bankadan kredi çekmişti. Annelerin %43’ünün tedavi sırasında ve sonrası ciddi psikolojik sorunlar yaşadığı, psikolojik sorunlarla başa çıkabilmek için ailelerin %40’ında tedavi döneminde dini ibadetlere eğilimde artış olduğu gözlendi. Hastalarımızın %83’ünün eğitimlerinde 1–2 yıl gibi bir kayıp yaşandığı görüldü. Çıkarımlar: Çocukluk çağı kanser hastaları ve aileleri tedavi sürecinde ve sonrasında önemli oranda psikosoyal ve ekonomik sorunlar yaşamaktadır. Kanserde, tıbbi tedavi ile psikososyal desteğin bir uyum içerisinde yürütülmesi tedavi başarısını artıran önemli bir etmendir. Hastanın ve ailesinin hastalıkla tanıştığı ilk andan başlayarak tüm hayat boyunca psikososyal destek mekanizmalarına gereksinim vardır. Ülkemizde ulusal olarak bu yönde geliştirilecek sosyal destek programları ve bu programın yürütüleceği zemini oluşturacak yasal düzenlemelere gereksinim vardır.Öğe Evaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?(Wiley, 2022) Zengin Ersoy, Gizem; Bozkurt, Ceyhun; Adaklı Aksoy, Başak; Başoğlu Öner, Özlem; Aydoğdu, Selime; Çipe, Funda; Sütçü, Murat; Özkaya, Ozan; Tunç, FışgınBackground: BKV-HC is one of the most significant complications of HSCT. This ret -rospective study aimed to determine the frequency of BKV-HC in pediatric patients undergoing HSCT, detect the associated risk factors for the development of BKV-HC, and explore the effects of post-transplantation Cy use.Methods: Three hundred twenty-seven patients (girls: 121, boys: 206) were analyzed according to sex, conditioning regimen, transplantation type, donor relatedness, stem cell source, the presence and grade of aGVHD, CMV co-existence, and Cy use.Results: Multivariate analysis confirmed the prognostic importance of age (OR: 4.865), TBI use, the presence of aGVHD (OR: 2.794), CMV coinfection (OR: 2.261), and Cy use (OR: 27.353). A statistically significant difference was found between the mean BKV-HC follow-up times compared with post-transplantation Cy intake (p< .001). The BKV-HC rate increased as the number of risk factors of the patient increased.Conclusion: BKV-HC is an essential complication of HSCT primarily associated with Cy use, the presence of aGVHD, and donor relatedness. The present study shows that the use of Cy in the post-transplantation period further increases BKV-HC risk in pediatric patients, regardless of dose.Öğe Extracorporeal photopheresis treatment for steroid resistant graft versus host disease in pediatrics: single center experience(Nature Publishing Group, 2019) Aksoy, Başak Adaklı; Savcı, Yunus Emre; Mergen, Azize; Aydoğdu, Selime; Dikme, Gürcan; Bozkurt, Ceyhun; Fışgın, TunçBackground: Steroid resistant graft vs host disease (GVHD) is de?ned as unresolved or worsened symptomatology of GVHD at day 14 despite effective immunosuppression with steroid therapy. Second line immunosuppressive agents, extracorporeal photopheresis (ECP) and/or mesenchymal stem cell therapies are being tried as salvage therapy.Öğe Hit three birds with one stone: successful stem cell transplantation from one family donor to three siblings(Nature Publishing Group, 2019) Aksoy, Başak Adaklı; Aydoğdu, Selime; Dikme, Gürcan; Mergen, Azize; Bozkurt, Ceyhun; Fışgın, TunçBackground: Thalassemia major is a single gene related hereditary hemoglobinopaty required life long regular transfusions with chelation therapies. Stem cell transplantation is the only curative treatment of the disease. Three sibling thalassemia patients 13,4 and 3 years old were succesfully transplanted from their only donor,fully matched seventeen years old sister at our center.Öğe Invasive saprochaete capitata Infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature(Springer/Plenum Publishers, 2020) Erman, Baran; Fırtına, Sinem; Aksoy, Başak Adaklı; Aydoğdu, Selime; Genç, Gonca Erköse; Doğan, Öner; Bozkurt, Ceyhun; Fışgın, Tunç; Erol Çipe, FundaPurpose Autosomal recessive (AR) CARD9 deficiency is an inherited immune disorder which results in impaired innate immunity against various fungi. Superficial and invasive fungal infections, mainly caused by Candida or Trichophyton species, are the hallmark of CARD9 deficiency. Together with the increasing number of CARD9-deficient patients reported, different pathogenic fungal species have been described such as Phialophora, Exophiala, Corynespora, Aureobasidium, and Ochroconis. Saprochaete capitata is an opportunistic infectious agent in immunocompromised patients and is a common cause of invasive fungal disease in patients with hematological malignancies. In this study, we investigated the causative genetic defect in a patient with S. capitata fungal infection which disseminated to lymph nodes and common bile duct. Methods The identification of the isolated yeast strain was made by direct microscopic examination and confirmed by internal transcribed spacer (ITS) sequencing. We applied whole exome sequencing to search for the disease-causing mutation. Sanger sequencing was used to validate the mutation in the patient and his parents. Results S. capitata was isolated from the biopsy specimen as the causative microorganism responsible for the invasive fungal disease in the patient. Whole exome sequencing revealed a homozygous c.883C > T, (p.Q295*) mutation in CARD9, confirmed by Sanger sequencing. Conclusions This is the first report of invasive Saprochaete infection associated with autosomal recessive (AR) CARD9 deficiency in the literature and thereby further extends the spectrum of fungal diseases seen in these patients.Öğe Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients(Galenos Publ House, 2023) Leventoglu, Emre; Sahin, Gurses; Yesil, Sule; Bozkurt, Ceyhun; Yuksek, Nazmiye; Fettah, Ali; Toprak, SuleObjective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment. IDH1 and IDH2 mutations have been found in many types of cancer, such as malignant gliomas, acute myeloid leukemias, chondrosarcoma, and thyroid carcinoma. This study aimed to investigate the presence of IDH1 or IDH2 mutations in patients with neuroblastoma and to determine whether these mutations were different in terms of age, clinical findings, and response to treatment.Methods: Biopsy specimens of 25 patients with pediatric neuroblastoma patients were evaluated for IDH mutations. The clinical and laboratory features of the patients with/without mutation were retrospectively analyzed from a hospital database. Results: A total of 25 patients for whom genetic analysis could be performed were included in the study (60% male, n=15). The mean age was 32.2 +/- 25.9 months (3 days-96 months). IDH1 mutation was detected in 8 (32%) and IDH2 mutations in 5 (20%) patients. These mutations showed no statistically significant relationship with age, tumor localization, laboratory results, stage, and prognosis. However, in the case of IDH mutation, patients were diagnosed at the advanced stage.Conclusions: This study demonstrated the relationship between neuroblastoma and IDH mutation for the first time. Because to the fact that the mutation is very heterogeneous, it would be appropriate to conduct a larger series of patients in terms of the impact of the clinical significance of each mutation on the diagnosis and prognosis.Öğe A novel candidate gene for predisposition of hodgkin lymphoma; Pregnan x receptor (PXR)(AMER SOC HEMATOLOGY, 2021) Kebudi, Rejin; Erbilgin, Yücel; Khodzhaev, Khusan; Sarıtaş, Merve; Bozkurt, Ceyhun; Sayitoğlu, MügeNo Abstract Available
