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    THE EFFECT OF INTRAOPERATIVE URETERAL CATHETER USAGE ON BACTERIURIA AND COMPLICATIONS IN DECEASED DONOR RENAL TRANSPLANTATION
    (Istanbul Univ, Fac Medicine, Publ Off, 2023) Canbay Torun, Bahar; Bayraktar, Adem; Aydin, Ali Emin; Bakkaloglu, Hueseyin
    Objective: The use of ureteral catheters in renal transplantation is controversial. We aimed to investigate the effect of intraoperative catheter use on bacteriuria and urological complications in deceased donor renal transplantation.Material and Method: Study design is cross sectional study. A total of 150 patients who underwent deceased donor renal transplantation in the Istanbul University Istanbul Faculty of Medicine Transplantation Unit were included in the study. Ureteral catheters were used in 72 patients but not in the remaining 78. The two patient groups were compared in terms of the incidence of early postoperative urological complications and bacteriuria in the first month after transplantation. Result: Ureteral catheter usage significantly reduced the frequency of early postoperative urological complications (p=0.004). The frequency of bacteriuria in the first month after transplantation was significantly lower in patients using ureteral catheters (p<0.001). In patients with ureteral catheters, the duration of anti-thymocyte globulin administration (p=0.003) and Foley catheter usage (p<0.001) was found to be significantly shorter than in the group without ureteral catheters.Conclusion: The routine use of ureteral catheters results in fewer urological complications in patients with deceased donor renal transplantation. Catheter use does not increase, and even lowers, the risk of early bacteriuria. The significant reduction in early
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    The role of PPAR-gamma C161T polymorphism in colorectal cancer susceptibility
    (Vivo, 2022) Kurnaz-Gomleksiz , Ozlem; Canbay Torun, Bahar; Isbir,Turgay; Bulut,Turker; Sokucu, Necmettin; Yilmaz-Aydogan, Hulya; Canbay, Emel
    Background/aim: This study aimed to determine the role of the peroxisome proliferator-activated receptor-gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). Patients and methods: PPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238). Results: The T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p<0.001; OR=3.239, 95%CI=1.997-5.252). Subgroup analysis showed that the T161 allele was associated with a 3.056-fold increased risk for colon cancer (CC) (p<0.001; 95%CI=1.709-5.464) and 3.529-fold increased risk for rectal cancer (RC) (p<0.001; 95%C=1.784-6.981). Frequencies of the T161 allele were also higher in total CRC and CC patients with poorly differentiated tumors (p<0.001, c2=30,601, OR=3.109; 95%CI=1.970-4.906 and p<0.001, Fisher exact test, respectively). Conclusion: PPARg T161 allele carriers have increased risk for developing CRC.