Yazar "Cecen, Berivan" seçeneğine göre listele

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    Application of Convergent Science and Technology toward Ocular Disease Treatment
    (Mdpi, 2023) Bal-Ozturk, Ayca; Ozcan-Bulbul, Ece; Gultekin, Hazal Ezgi; Cecen, Berivan; Demir, Ebru; Zarepour, Atefeh; Cetinel, Sibel
    Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.
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    Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation
    (Elsevier Advanced Technology, 2023) Cecen, Berivan; Saygili, Ecem; Zare, Iman; Nejati, Omid; Khorsandi, Danial; Zarepour, Atefeh; Alarcin, Emine
    Because of the brain's complexity, developing effective treatments for neurological disorders is a formidable challenge. Research efforts to this end are advancing as in vitro systems have reached the point that they can imitate critical components of the brain's structure and function. Brain-on-a-chip (BoC) was first used for microfluidics-based systems with small synthetic tissues but has expanded recently to include in vitro simulation of the central nervous system (CNS). Defining the system's qualifying parameters may improve the BoC for the next generation of in vitro platforms. These parameters show how well a given platform solves the problems unique to in vitro CNS modeling (like recreating the brain's microenvironment and including essential parts like the blood-brain barrier (BBB)) and how much more value it offers than traditional cell culture systems. This review provides an overview of the practical concerns of creating and deploying BoC systems and elaborates on how these technologies might be used. Not only how advanced biosensing technologies could be integrated with BoC system but also how novel approaches will automate assays and improve point-of-care (PoC) diagnostics and accurate quantitative analyses are discussed. Key challenges providing opportunities for clinical translation of BoC in neurodegenerative disorders are also addressed.
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    Current strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlook
    (Bentham Science Publ Ltd, 2018) Bal Öztürk, Ayça; Miccoli, Beatrice; Avcı Adalı, Meltem; Mogtader, Ferzaneh; Sharifi, Fatemeh; Cecen, Berivan; Yaşayan, Gökçen; Braeken, Dries; Alarçin, Emine
    The skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant endpoint for the application of pharmaceuticals. The area of in vitro skin tissue engineering has been progressing extensively in recent years. Advanced in vitro human skin models strongly impact the discovery of new drugs thanks to the enhanced screening efficiency and reliability. Nowadays, animal models are largely employed at the preclinical stage of new pharmaceutical compounds development for both risk assessment evaluation and pharmacokinetic studies. On the other hand, animal models often insufficiently foresee the human reaction due to the variations in skin immunity and physiology. Skin-on-chips devices offer innovative and state-of-the-art platforms essential to overcome these limitations. In the present review, we focus on the contribution of skin-on-chip platforms in fundamental research and applied medical research. In addition, we also highlighted the technical and practical difficulties that must be overcome to enhance skin-on-chip platforms, e. g. embedding electrical measurements, for improved modeling of human diseases as well as of new drug discovery and development.
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    Selection of natural biomaterials for micro-tissue and organ-on-chip models
    (2022) Bal Öztürk, Ayça; Cecen, Berivan; Yaşayan, Gökçen; Alarçin, Emine; Koçak, Polen; Tutar, Rümeysa; Kozacı, Leyla Didem; Ryon Shin, Su; K Miri, Amir
    The desired organ in micro-tissue models of organ-on-a-chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural-based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural-based biomaterials and summarize recent reports on their applications in the design and fabrication of micro-tissue models. This article will help bioengineers select the proper biomaterials based on developing new techn
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    Tissue adhesives: From research to clinical translation
    (Elsevier B.V., 2021) Bal Öztürk, Ayça; Cecen, Berivan; Avcı Adalı, Meltem; Topkaya, Seda Nur; Alarçin, Emine; Yaşayan, Gökçen; Li, Yi Chen Ethan; Bulkurcuoğlu, Bünyamin; Akpek, Ali; Avcı, Hüseyin; Shi, Kun; Shin, Suryon; Hassan, Shabir
    Sutures, staples, clips, and skin closure strips are used as the gold standard to close wounds after an injury. In spite of being the present standard of care, the utilization of these conventional methods is precarious amid complicated and sensitive surgeries such as vascular anastomosis, ocular surgeries, nerve repair, or due to the high-risk components included. Tissue adhesives function as an interface to connect the surfaces of wound edges and prevent them from separation. They are fluid or semi-fluid mixtures that can be easily used to seal any wound of any morphology-uniform or irregular. As such, they provide alternatives to new and novel platforms for wound closure methods. In this review, we offer a background on the improvement of distinctive tissue adhesives focusing on the chemistry of some of these products that have been a commercial success from the clinical application perspective. This review is aimed to provide a guide toward the innovation of tissue bioadhesive materials and their associated biomedical applications.