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    A dosimetric comparison of 7 field IMRT, 9 feld IMRT, VMAT and 3-D conformal radiotherapy for the treatment of localized intermediate risk prostate cancer
    (UHOD - Uluslararasi Hematoloji Onkoloji Dergisi, 2022) Ekici, Kemal; Kuloğlu, Mehmet; Ata, Aysun Özsoy; Atahan, Özcan; Tiryakioğlu, Osman
    The objective of this study was to invastigate the potential role of various radiotherapy planning methods for localised intermediate risk prostate cancer. We compare Linac-based 7 field intensity modulated radiation therapy (IMRT), 9 field IMRT, volumetric modulated arc therapy (VMAT) and 3-D conformal radiotherapy (3D-CRT) techniques for localised prostate cancer. Forty plans with localised prostate cancer treated at our institution were randomly selected for this study. Ten radiotherapy treatment plans have been created for all 10 patients, including 7 field IMRT, 9 field IMRT, VMAT and 3D-CRT. All plans were designed to deliver 76 Gy in 38 fractions to the planning target volume (PTV). The HI and CI for 7-IMRT, 9-IMRT and VMAT modalities were better than 3D-CRT. For the CI, VMAT was better than 9-IMRT and 3D-CRT, but no significant difference was found with 7-IMRT modality. PTVDmax was found to be lower in 3D-CRT compared to other three treatment methods. VMAT was better than 3D-CRT in femoral head V30, but there was no difference between other modalities. In the number of monitor units(MU) 3D-CRT was found to be lower than the other modalities, in VMAT the number of MU’s was found to be lower than 7 and 9-IMRT modalities. It was observed that the three IMRT modalities studied showed superior target coverage with less variation between each plan in comparison to 3D-CRT. VMAT treatment duration and femoral head V30 dose were superior to IMRT techniques. © 2022, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.
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    Stereotactic Body Radiotherapy in Non-Small Cell Lung Cancer Patients: Assessment of Response and Toxicity at Single İnstitution
    (2022) Ekici, Kemal; Kömürcüoğlu, Berna; Ölmezoğlu, Ali
    Objective: The aim of this study is to assess the efficacy and acute toxicity of stereo tactic body radiotherapy (SBRT) for either primary or metastatic masses of lung tumors. Material and Methods: Analysis was performed on 110 lung tumor masses (primarily non-small cell origin, a small proportion was metastatic) patients treated by CyberKnife® in our clinic between February 2010 and July 2015. Doses had been delivered ranged 20–60 Gy, in one to seven once-daily fractions, depending on tumor size and location. Results: The median follow-up duration after SBRT was 29 months (range 14, 75–40 months). The median overall survival (OS) was 31.62 months (95% CI, 24.06–37.93 months). 3-year survival was 42% and 5-year survival was 22%. Conclusion: Lung tumors (primary or metastatic) treated by SBRT had better treat ment response and less toxicity compared with conventional radiotherapy schedules. If available-depending on size and location of the tumor(s) - SBRT is the most afford able; preferable option.