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    ROLE OF THE DUCTUS THORACICUS IN PULMONARY FAT EMBOLISM AFTER SUBARACHNOID HAEMORRHAGE: A PRELIMINARY EXPERIMENTAL STUDY
    (Istanbul University Press, 2025) Kına, Hakan; Elveren, Muhammet
    Objective: Subarachnoid haemorrhage is a multisystemic disease due to its effects on the autonomic nervous system. Pulmonary tissues may be affected due to its effects on the intestinal system, lipid metabolism, and ductus thoracicus in subarachnoid haemorrhage. This study demonstrate the pathophysiology of pulmonary fat embolism after sympathetic activation of the ductus thoracicus with lipid absorption disorders after subarachnoid haemorrhage. Material and Methods: In the study, 24 male rabbits were used, of which five were selected as the control group (GI) and five as the SHAM group (GII). The SHAM group was injected with a 0.7 mL isotonic solution into the cisterna magna. The study group (GIII) was injected with 0.7 mL autologous blood into the cisterna magna. The lymphatic vessels in the middle sections of the duodenum, the thoracic duct portions opening into the jugular vein, and the terminal branches of the pulmonary arteries were examined and counted. Results: The thoracic duct vasospasm index (VSI) values and numbers of branches occluded by fat particles in the pulmonary arteries were: 1.65±0.22/3.21±0.54 in GI, 1.97±0.34/7.3±2.4 in GII, and 2.54±0.56/14.53±14.53 in GIII. In the six subjects with severe thoracic duct spasm in GIII, the number of pulmonary arteries occluded with chylomicrons was higher (p>0.00001). P values among groups were: p > 0.05 in GI/GII; p<0.005 in GII/GIII and p<0.0001 in GI/GIII. Conclusion: This is the first experimental study conducted on animals investigating the lipid metabolism disorder associated with subarachnoid haemorrhage affecting the cervical ganglia, thoracic duct spasm, and pulmonary fat embolism. © 2025 Istanbul University Press. All rights reserved.