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    Analysis of serum nickel, silicium, arsenic and boron in smoking ındividuals
    (DergiPark, 2021) Ateş Alkan, Fatma; Karış, Denizhan; Çakmak Uzan, Gülfidan; Ercan, Alev Meltem
    Smoking induces inflammation and oxidative stress via radical production from chemicals resulting in cardiocerebrovascular and respiratory diseases, cancers, stroke and sudden death. Elements found in tobacco plant and tobacco smoke are absorbed into blood circulation and transferred into blood and peripheral tissues. The aim of the present study is to evaluate the alterations of serum nickel (Ni), silicium (Si), arsenic (As) and boron (B) levels in smokers. The study groups were categorized as individuals who quitted smoking (Group 1; n: 35; 15 female/20 male), who were smoking (Group 2; n:35; 13 female, 22 male) and who never-smoked (Group 3; n; 40; 20 female/20 male). Biochemical parameters were analyzed in Biochemistry Laboratory of Haseki Traning and Research Hospital. Serum element levels were measured using Inductively Coupled Plasma Atomic Emission Spectroscopy in Trace Element Laboratory of Biophysics Department of Cerrahpasa Medical Faculty at Istanbul University-Cerrahpasa. ANOVA test and Pearson’s correlation tests were used for statistical analysis and p < 0.05 was evaluated as statistically significant. Serum Ni levels of Group 2 were higher than the other study groups with no significance. Group 2 had statistically higher serum Si and As levels than Group 1 and Group 3 (p < 0.01, p < 0.05, respectively). There was no statistical significance by means of serum B levels among study groups. Increased serum levels of Si and As in smokers might induce atherosclerosis via inflammation, dyslipidemia and burden oxidative stress. Besides, higher serum Ni levels of smokers might reflect its toxic effects. However, serum B was lower in smokers probably related with its consumption in biological defence mechanisms. Monitorization of serum nickel, silicium, arsenic and boron levels should be considered as biomarkers for smokers.
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    The effects of vitamin d and microfracture surgery technique on calcium and phosphorus: a pilot study
    (2020) Tarhan, Duygu; Tok, Okan; Karış, Denizhan; Ercan, Alev Meltem
    Objectives: Vitamin D has an important effect on calcium (Ca) and phosphorus (P) metabolism and bone health. It helps regulate the ratio of Ca and P. The aim of this study was to investigate the effects of vitamin D and minor surgical stress on Ca and P levels in the liver, kidneys, and serum in 24 New Zealand rabbits with cartilage defects. Methods: Experimental groups of MFS (only microfracture surgery), Vit D (only oral vitamin D supplementation), and MFS+Vit D (both microfracture surgery and oral vitamin D supplementation) were created. The levels of Ca and P in serum, liver, and kidney samples were measured using a spectrophotometric method. Results: The kidney Ca/P ratio was lower and the serum Ca/P ratio was higher in the MFS+Vit D groups than in the control group. The serum P level was significantly lower in the MFS and MFS+Vit D groups when compared with the control group. Conclusion: To the best of our knowledge, this is a novel study examining microfracture surgery and the effect on Ca and P. The Ca/P ratio revealed clinically valuable information about the important balance between Ca/P ratio and the adequacy of vitamin D. Vitamin D supplementation before microfracture surgery may be beneficial and may prevent a de creased Ca/P ratio due to the effect of surgical stress.
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    Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis
    (ELSEVIER GMBH, 2022) Tekin, Tuba Özkan; Karış, Denizhan; Alkan, Fatma Ateş; Çetin, Güven; Ercan, Alev Meltem
    Background: Trace elements (TE) are vital for cellular mechanisms at biological, chemical and molecular levels. The effects of TE in diagnosis, progression and treatment of essential thrombocytosis (ET), which is one of the chronic myeloproliferative neoplasms is a rare clonal stem cell disease characterized by increased thrombocyte numbers with impaired function, have not been elucidated in detail yet. The aim of the present study was to investigate the effects of TE alterations in an ET model and the efficacy of TE in ET treatment protocol by means of a vast number of TE.Methods: Study groups were categorized as patients with ET diagnosis (ET group, n:30), patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA-RT) (IDA-RT group, n:30) and healthy controls (HC group, n:30). Serum levels of copper (Cu), iron (Fe), cobalt (Co), chromium (Cr), aluminum (Al), silicon (Si), nickel (Ni), zinc (Zn), selenium (Se), manganese (Mn), boron (B) and magnesium (Mg) were analyzed utilizing inductively coupled plasma-optical emission spectrophotometer instrument (ICP-OES). Statistical analysis was evaluated using SPSS 23.0.Results: ET group had statistically higher serum levels of Co and Mg (p < 0.05), Ni and Mn (p < 0.001), and lower Si (p < 0.05) than IDA-RT group. ET group had statistically higher serum levels of Co and Mn (p < 0.05), and Ni (p < 0.001), and lower Al, Si and Se (p < 0.001) than HC group. Serum levels of Fe, Al and Se (p < 0.001), and Mg (p < 0.01), and Zn (p < 0.05) in IDA-RT group were significantly lower than HC group.Conclusion: This novel study pointed out that alterations of many serum TE by means of both increment or decrement might have close relationship with mechanisms and complications of ET onset and follow-up. We consider that further research of TE would elucidate ethiopathogenesis and prognosis of ET. Thus, analysis of serum trace elements in essential thrombocytosis patients may be an important protocol by means of diagnosis, treatment and follow-up intervals.
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    The investigation of plasma viscosity and endothelial dysfunction markers between patients diagnosed with essential thrombocytosis and reactive thrombocytosis
    (Pergamon-Elsevier Science Ltd, 2019) Karış, Denizhan; Tekin, Tuba Özkan; Çetin, Güven; Ercan, Alev Meltem
    Essential thrombocytosis (ET) is a rare stem cell disease causing increased platelet numbers with impaired function. Biomechanical force applied by plasma viscosity-a major determinant of blood flow-alterations on endothelium, induces endothelial cells for secretion of endothelial dysfunction markers. The aim of our study is to investigate the relationship between plasma viscosity and nitric oxide (NO), asymmetric dimethylarginine (ADMA), vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) as endothelial dysfunction markers in plasma.