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  • Küçük Resim
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    Changes in various hormone levels in The rabbit traumatic facial nerve injury model
    (Deomed Publ, Istanbul, 2018) Kapusuz Gencer, Zeliha; Özkiriş, Mahmut; Gencer, Muzaffer; Göçmen, Ayşe Yeşim; Dağlıoğlu, Yusuf Kenan
    Objectives: We aimed to look into potential associations between specific biomarkers and trauma to Cranial Nerve VII (CNVII) in a rabbit model, focusing on whether endocrine studies have potential as biomarkers in this context. Methods: 30 adult New Zealand rabbits with intact facial muscles were used for the research. Each animal underwent identical surgery by the same surgeon. The facial nerve divisions were exposed by incising below the level of the mandible. After dissection of the skin and subcutaneous layers, the buccal division of CNVII was located with the nerve stimulator and microscopic dissection and a section of nerve 10mm long was excised in each case from the buccal branch of CNVII. Blood samples were drawn 8 weeks and 12 weeks after nerve injury had been surgically induced. The samples from day 1, week 4 and week 8 were tested for the following levels: Testosterone, oestrogen, progesterone, free T3 and T4, Cancer antigen 19-9 (Ca19-9), folate, TPSA, FPSA, FSH, LH, CA15.3, CAE, AFP and prolactin. Results: The levels of free T3 and T4 as well as testosterone, were down at 4th week, but at 8 weeks each had increased. Ca19-9 levels were also above the baseline. At 4 weeks, whilst oestrogen had markedly risen, progesterone had fallen. The statistical significance of the change in levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA was evaluated. For the group of animals with induced paralysis, the association between the lesion and testosterone, oestrogen, progesterone, free T3 and T4, Ca19-9, and folate levels were strong and at the level of statistical significance. Conclusion: There were statistically significant alterations in the serum levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA at the 4 and 8 week intervals post surgically-induced CNVII injury. It is likely that rabbit pathophysiology resembles human pathophysiology in nervous injury, hence these six biomarkers may be of value in managing trauma or idiopathic degeneration of CNVII in humans. The authors hope this study will pave the way for future research in this area.
  • Küçük Resim Yok
    Öğe
    Changes In Various Hormone Levels In The Rabbit Traumatic Facial Nerve Injury Model
    (2018) Göçmen, Ayşe Yeşim; Dağlıoğlu, Yusuf Kenan; Kapusuz, Zeliha; Özkırış Özkırış, Mahmut; Gence, Muzaffer
    Objectives: We aimed to look into potential associations betweenspecific biomarkers and trauma to Cranial Nerve VII (CNVII) in a rabbitmodel, focusing on whether endocrine studies have potential as biomarkers in this context.Methods: 30 adult New Zealand rabbits with intact facial muscleswere used for the research. Each animal underwent identical surgeryby the same surgeon. The facial nerve divisions were exposed by incising below the level of the mandible. After dissection of the skin andsubcutaneous layers, the buccal division of CNVII was located with thenerve stimulator and microscopic dissection and a section of nerve10mm long was excised in each case from the buccal branch of CNVII.Blood samples were drawn 8 weeks and 12 weeks after nerve injuryhad been surgically induced. The samples from day 1, week 4 andweek 8 were tested for the following levels: Testosterone, oestrogen,progesterone, free T3 and T4, Cancer antigen 19-9 (Ca19-9), folate,TPSA, FPSA, FSH, LH, CA15.3, CAE, AFP and prolactin.Results: The levels of free T3 and T4 as well as testosterone, weredown at 4th week, but at 8 weeks each had increased. Ca19-9 levelswere also above the baseline. At 4 weeks, whilst oestrogen had markedly risen, progesterone had fallen. The statistical significance of thechange in levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA was evaluated. For the group of animals with inducedparalysis, the association between the lesion and testosterone, oestrogen, progesterone, free T3 and T4, Ca19-9, and folate levels werestrong and at the level of statistical significance.Conclusion: There were statistically significant alterations in the serum levels of free T3 and T4, testosterone, oestrogen, progesteroneand FPSA at the 4 and 8 week intervals post surgically-induced CNVII injury. It is likely that rabbit pathophysiology resembles humanpathophysiology in nervous injury, hence these six biomarkers may beof value in managing trauma or idiopathic degeneration of CNVII inhumans. The authors hope this study will pave the way for future research in this area
  • Küçük Resim
    Öğe
    Prevalence of human pseudocholinesterase (butyrylcholinesterase) deficiency in central Anatolian people: a cross-sectional study
    (DergiPark, 2020) Gencer, Muzaffer; Göçmen, Ayşe Yeşim
    Aim: Human pseudocholinesterase (PChE) is an enzyme responsible for hydrolysis of the muscle relaxant drugs like succinylcholine and mivacurium. PChE deficiency, which may lead to prolonged apnea, may occur due to hereditary or acquired causes. In our study, we aimed to investigate the prevalence of human pseudocholinesterase (PChE) enzyme deficiency around the central Anatolia region and present our results in light of the literature. Methods: This cross-sectional study included 936 patients (age 18-70 years) who underwent any elective surgery under general anesthesia between August 2015 and September 2019. Human PChE level, plasma PChE activity, the human PChE activity/albumin, serum liver and kidney function tests were analyzed from blood samples. Human PChE enzyme deficiency and possible association of the PChE deficiency with other values was also investigated. The normal value of PChE was considered to range from 4650 U/L to 10,440 U/L. Results: PChE activity was decreased in 19 (1.9%) of the 936 patients (442 males and 494 females). There was no statistically significant difference between the PChE levels in terms of gender (P=0.236). The mean human PChE activity of all patients was 7.490 (0.980). The PChE activity of 22 (2.35%) and 58 patients (6.4%) were below 5.000 U/ml and 6.000 U/, respectively. A statistically significant difference was found between serum urea, creatinine and human PChE levels (P=0.034, P=0.236, respectively). However, PChE deficiency had no correlation with liver function tests such as AST and ALT (P=0.432, P=0.022, respectively). Conclusion: PChE deficiency can be observed in preoperatively evaluated patients and may cause serious life-threatening conditions, including respiratory failure and prolonged apnea.