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    Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
    (Bmc, 2023) Gunaydin-Akyildiz, Aysenur; Yanikoglu, Rabia Sare; Gulec, Meltem; Alim-Toraman, Gulbahar Ozge; Kuran, Ebru Didem; Atasoy, Sezen; Olgun, Abdullah
    BackgroundEmodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active role in wound healing, is a well-characterized large family of serine/threonine kinases and regulates processes such as proliferation, oncogenesis, differentiation, and inflammation in the cell. The aim of this study is to comparatively elucidate the mechanisms of action of emodin and aloe-emodin, which are potential agents in wound healing.MethodsThe mechanism of the effects of emodin and aloe-emodin on cell viability and cell migration was examined using the human skin fibroblast (CCD-1079Sk) cell line. The gene expression levels of the MAP kinases (JNK, P38, ERK) in the skin fibroblast cells along with a molecular docking study analyzing their interaction potential were evaluated. Furthermore, the molecules' effects on the lifespan of Caenorhabditis elegans were studied.ResultsEmodin and aloe-emodin inhibited the ATP content of the cells in a concentration dependent manner and accelerated cell migration at the lower concentrations while inhibiting cell migration in the higher concentration treatment groups. The expressions of JNK and P38 were upregulated at the low concentrations and downregulated at the higher concentrations. The molecular docking studies of the molecules gave high docking scores indicating their interaction potential with JNK and P38. C. elegans lifespan under heat stress was observed longer after 75 & mu;M emodin and was significantly reduced after 150 & mu;M aloe-emodin treatment.ConclusionAloe-emodin was found to be more potent on cell viability, cell migration, gene expression levels of the MAP kinases in healthy fibroblastic skin cells, and on the lifespan of C. elegans. This study reveals the functional effects and the biological factors that interact in the wound healing process of emodin and aloe-emodin, and give a possible treatment alternative to shorten the duration of wound care.
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    The Medicinal Plants Traditionally Used Against Cardiovascular Diseases in Türkiye
    (2023) Gulec, Meltem; Erarslan, Zeynep Busra; Kultur, Sukran
    Since immemorial, humankind has benefited from plants as nutritient, medicine, cosmetic, or to make tools and shelters for itself. Historically, the trial-and-error method gathered traditional knowledge; practices were developed and sustained. It has been passed on from generation to generation to reach our day. This study aims to gather information on medicinal plants used traditionally against cardiovascular diseases in Türkiye before it is lost forever. In the library of Istanbul University, in the first place, the approachable sources have been scanned thoroughly. Plants’ scientific name, Turkish name, family, used parts, method of use, and effects has been put together in a table. As a result, we composed a report of 129 plants from 43 families used for cardiovascular diseases. It has been concluded that of these, the most outstanding herbs are Crataegus monogyna Jacq., Lavandula stoechas L., Melissa officinalis L., Tribulus terrestris L., Urtica dioica L. and Viscum album L. Rosaceae, Lamiaceae and Asteraceae were the most used plant families. It has been detected that people mainly benefit from the leaves, aerial parts, fruit, and flowers of medicinal plants as infusion or decoction. Although the biological activity studies on the plants most used by the people support the use in cardiovascular diseases, more studies are needed to provide scientific evidence for folklore use, especially for L. stoechas. It is thought that this study may be a resource for developing future herbal medicines or treatments.