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    Antiamoebic properties of Methyltrioctylammonium chloride based deep eutectic solvents
    (Elsevier Ltd., 2022) Siddiqui, Ruqaiyyah; Makhlouf,Zinb; Akbar, Noor; Khamis, Mustafa; Ibrahim, Taleb; Khan, Amir Sada; Khan, Naveed Ahmed
    Antiamoebic properties of Methyltrioctylammonium chloride based deep eutectic solvents
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    Antimicrobial Activity of Novel Deep Eutectic Solvents
    (Mdpi, 2023) Akbar, Noor; Khan, Naveed Ahmed; Ibrahim, Taleb; Khamis, Mustafa; Khan, Amir Sada; Alharbi, Ahmad M.; Alfahemi, Hasan
    Herein, we utilized several deep eutectic solvents (DES) that were based on hydrogen donors and hydrogen acceptors for their antibacterial application. These DES were tested for their bactericidal activities against Gram-positive (Streptococcus pyogenes, Bacillus cereus, Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus) and Gram-negative (Escherichia coli K1, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens) bacteria. Using lactate dehydrogenase assays, DES were evaluated for their cytopathic effects towards human cells. Results from antibacterial tests revealed that DES prepared from the combination of methyl-trioctylammonium chloride and glycerol (DES-4) and DES prepared form methyl-trioctylammonium chloride and fructose (DES-11) at a 2 mu L dose showed broad-spectrum antibacterial behavior and had the highest bactericidal activity. Moreover, DES-4 showed 40% and 68% antibacterial activity against P. aeruginosa and E. coli K1, respectively. Similarly, DES-11 eliminated 65% and 61% E. coli K1 and P. aeruginosa, respectively. Among Gram-positive bacteria, DES-4 showed important antibacterial activity, inhibiting 75% of B. cereus and 51% of S. pneumoniae. Likewise, DES-11 depicted 70% B. cereus and 50% S. pneumoniae bactericidal effects. Finally, the DES showed limited cytotoxic properties against human cell lines with the exception of the DES prepared from Methyltrioctylammonium chloride and Citric acid (DES-10), which had 88% cytotoxic effects. These findings suggest that DES depict potent antibacterial efficacies and cause minimal damage to human cells. It can be concluded that the selected DES in this study could be utilized as valuable and novel antibacterial drugs against bacterial infections. In future work, the mechanisms for bactericides and the cytotoxicity effects of these DES will be investigated.
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    COVID-19: Acanthamoeba Creeps into the Brain
    (Iranian Scientific Society Medical Entomology, 2023) Siddiqui, Ruqaiyyah; Niyyati, Maryam; Abouleish, Mohamed Yehia; Khamis, Mustafa; Ibrahim, Taleb; Khan, Naveed Ahmed
    [Abstract Not Available]
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    The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties
    (Springer, 2023) Siddiqui, Ruqaiyyah; Khodja, Abdelhamid; Ibrahim, Taleb; Khamis, Mustafa; Anwar, Ayaz; Khan, Naveed Ahmed
    With the rise of antibiotic resistance globally, coupled with evolving and emerging infectious diseases, there is an urgent need for the development of novel antimicrobials. Deep eutectic solvents (DES) are a new generation of eutectic mixtures that depict promising attributes with several biological implications. DES exhibit unique properties such as low toxicity, biodegradability, and high thermal stability. Herein, the antimicrobial properties of DES and their mechanisms of action against a range of microorganisms, including bacteria, amoebae, fungi, viruses, and anti-cancer properties are reviewed. Overall, DES represent a promising class of novel antimicrobial agents as well as possessing other important biological attributes, however, future studies on DES are needed to investigate their underlying antimicrobial mechanism, as well as their in vivo effects, for use in the clinic and public at large.