Yazar "Jahed, Ali" seçeneğine göre listele

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    A sustainable vaccine supply-production-distribution network with heterologous and homologous vaccination strategies: Bi-objective optimization
    (Elsevier Ltd., 2025) Jahed, Ali; Hadji Molana, Seyyed Mohammad; Tavakkoli Moghaddam, Reza
    Heterologous and homologous Coronavirus Disease 2019 (COVID-19) vaccination against Severe Acute Respiratory Syndrome (SARS)-CoV-2 are robust and proactively adaptable strategies. However, there is still a lack of appropriate mathematical models for integrating vaccination strategies into the vaccine supply chain network. This study develops a supply-production-distribution-inventory-allocation problem in the Sustainable Vaccine Supply-Production-Distribution Network (SVSPDN) to fill this gap for the first time. The outstanding novelties of this research are prioritizing vaccines and sequencing injection doses to increase vaccination effectiveness. In addition, the remarkable new contribution of the proposed mathematical model is the design of new bi-objective, multi-dose, multi-level, and multi-period to ensure the sustainability performance of the entire network. This aim is achievable by minimizing the cost of supplying, producing, and distributing vaccines and fulfilling social goals by maximizing vaccination effectiveness. Also, a scenario-based robust stochastic optimization approach is presented to handle uncertainties. Since the SVSPDN design is an NP-hard problem, to solve the proposed mathematical model, three Pareto-based evolutionary algorithms, including Non-Dominated Sorting Genetic Algorithm II (NSGA-II), Multi-Objective Particle Swarm Optimization (MOPSO), and Multi-Objective Gray Wolf Optimizer (MOGWO), are applied. The Taguchi design method is applied to tuning the parameters due to the sensitivity of meta-heuristic algorithms to input parameters. Then, a comparison is performed using four assessment metrics, including the Number of Pareto Solutions (NPS), Diversification Matrix (DM), Mean Ideal Distance (MID), Spread of Non-Dominance Solutions (SNS), and Computation Time (CT). The results reveal that the NSGA-II and MOGWO algorithms have performances that are very close to each other. However, MOGWO performs better in tackling the problem and is superior to the NSGA-II and MOPSO regarding assessment metrics and computation time. A case study of Iran is investigated to indicate the efficiency and applicability of the proposed model. Finally, sensitivity analyses, managerial insights, and practical implications are discussed. © 2024 Elsevier Ltd
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    Designing an integrated sustainable-resilient mix-and-match vaccine supply chain network
    (Springer, 2024) Jahed, Ali; Molana, Seyyed Mohammad Hadji; Tavakkoli Moghaddam, Reza; Valizadeh, Vahideh
    Vaccination is the most effective strategy for battling infectious diseases, breaking the disease transmission chain, and achieving herd immunity. Implementing vaccination for the whole population requires an integrated vaccine supply chain network that considers sustainability and resiliency in the network. For this purpose, in this research, a location-allocation-inventory-distribution problem in the sustainable and resilient vaccine supply chain network, considering mix-and-match vaccine regimens against SARS-CoV-2, is designed. The mix-and-match-based vaccination to reach robust immunization, increase vaccination effectiveness, and more resilience to cope with shortages is applied. In addition, three pillars of sustainability, to minimize distribution network costs, vaccine disposal impact, and greenhouse gas emissions, in terms of economic and environmental, and maximizing job creation, demand satisfaction, and vaccination effectiveness to ensure social sustainability, are developed. Also, scenario-based optimization is presented to meet the inevitable disruptions and breakdowns, such as the supply capacity of suppliers and uncertain amounts of vaccine demand, which depends on the previous type of vaccine injected, and robust stochastic programming is used to handle uncertainties. To solve the proposed model, efficient meta-heuristic algorithms, including the genetic algorithm (GA) and variable neighborhood search (VNS), are applied. In addition, a new hybrid algorithm called H-GAVNS based on the GA and VNS is developed in this research to discover near-optimal results. Finally, a case study of the COVID-19 vaccine in Iran’s environment is presented to confirm the accuracy of the presented model. The outcomes show that uncertainties in the real world and sustainability and resiliency aspects are well managed and responded to by the designed model. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.