Yazar "Kaya, Burak" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Effect of pirfenidone on tendon healing
    (Wolters Kluwer Medknow Publications, 2023) Aydinli, Yasemin; Kaya, Burak; Abou Monsef, Yanad; Eyidogan, Abdullah
    Background: The most critical issues in tendon healing include tendon adhesions and a loss of tendon strength. Adhesions result from fibrotic tissues developing in both surrounding tissues and tendons. Materials and Methods: Twenty-four rats were divided into two groups. Their Achilles tendons were cut 4 mm proximal to the calcaneal insertion and sutured with 6 / 0 monofilament nonabsorbable sutures. In the control group, saline solution was applied to the surgical field. In the experimental group, pirfenidone was applied to the surgical field locally and given orally for each rat to provide both local and systemic effects for 14 days following surgery. After a gait analysis, rats were sacrificed during the 4th postoperative week, and macroscopical, histopathological, and biomechanical analyses were performed. Results were compared with the statistical analyses. Results: The macroscopic scores of the experimental group were significantly higher than the control group (P = 0.007). The Achilles functional index scores were not significantly different between the two groups (P = 0.55). Histopathological scores were substantially closer to healthy tendons in the experimental group (P = 0.004). Biomechanically, the force required to rupture the tendons and tendon stiffness was significantly greater in the experimental group than in the control group (P = 0.028 for both). Conclusion: This study shows that tendons healed better with pirfenidone treatment.
  • Küçük Resim
    Öğe
    Evaluation of increased intracranial pressure with the optic nerve sheath diameter by ultrasound in epiduroscopic neural laser discectomy procedures
    (AM SOC INTERVENTIONAL PAIN PHYSICIANS, 2021) Beyaz, Serbülent Gökhan; Kaya, Burak; Ülgen, Ali Metin; Şahin, Fatih; Kocayiğit, Havva; Issı, Zeynep Tuncer
    Background: In order to clarify the camera image and open the adhesions mechanically during epiduroscopy, saline is injected continuously in the epidural area. As a result, an increase in intracranial pressure is to be expected in theory. Increased intracranial pressure can be evaluated by measuring by optic nerve sheath diameter. Objectives: This study was designed to evaluate the relationship between optic nerve sheath diameter measurements and intracranial pressure, after injecting fluid to the epidural area during epiduroscopy procedures performed in our clinic. Study Design: Retrospective study. Setting: Sakarya University Training and Research Hospital. Methods: During the epiduroscopy procedure, pre and postoperative bilateral optic nerve sheath diameters were measured with an ultrasonography probe. With the patients' eyelids closed, the probe was placed on the orbita in the sagittal plane, measuring 3 mm posterior of the papilla. Results: While there was a statistically significant difference between pre- and post-operative optic nerve sheath diameter measurements, there was no significant correlation with processing time, amount of fluid delivered, or fluid delivery rates. Limitations: One of the limitations of this study is the retrospective collection of data. A second limitation is that repetitive measurements were not performed, instead of a single postoperative measurement. Conclusion: We think more prospective randomized controlled studies are required to examine the increase in the diameter of the optic nerve sheath, which is an indirect indicator of increased intracranial pressure after epiduroscopy applications, in order to determine whether the pressure increase is associated with the rate of fluid delivery, the total fluid amount, or the processing time.
  • Küçük Resim
    Öğe
    An unexpected weight loss in a morbid obese patient with spinal cord stimulation therapy for chronic neuropathic pain
    (Springer, 2021) Beyaz, Serbülent Gökhan; Kaya, Burak
    Obesity is a multifactorial and complex disease that occurs due to the interaction of genetic and environmental factors. It has been reported that 7% of the adult population globally and 27% of the American population are obese [1]. Obesity is associated with myocardial infarction, cerebrovascular diseases, and sudden death among cardiovascular diseases and increasingly affects the young population.