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    The effect of lactobacillus rhamnosus GG in infants with food protein-induced allergic proctocolitis
    (Galenos publishing house, 2024) Avcı, Özgecan; Usta, Merve; Kaya, Ayşenur; Kaya, Nesrin; Urgancı, Nafiye
    BACKGROUND/AIMS: Most infants with food protein-induced allergic proctocolitis (FPIAP) achieve clinical tolerance between 1 and 3 years of age. The aim of this study was to investigate the effect of Lactobacillus rhamnosus GG on the development of tolerance in infants who are exclusively breastfed and diagnosed with FPIAP. MATERIALS AND METHODS: Sixty infants with FPIAP were divided into two groups: group 1 (study); who received probiotic Lactobacillus rhamnosus GG for 3 months, and group 2 (control); who did not. Clinical characteristics, allergy tests, and tolerance development were examined. RESULTS: Thirty patients [mean age: 3.9 +/- 1.3, range: 2-6 months, male/female (M/F): 1.7] in group 1 and 30 patients (mean age: 4.1 +/- 1.3, range: 1.4-6 months, M/F: 0.7) in group 2 were included in the study. The reintroduction of trigger foods into the mothers' diet at 9 months was significantly higher in group 1 than in group 2 (63.3% versus 26.7% of the patients, respectively, p=0.004). No significant difference was observed in terms of the resolution time of symptoms and time of tolerance development between groups and subgroups. CONCLUSION: A significant difference was observed in the mean time to reintroduce trigger foods into the maternal diet, the number of mothers who first reintroduced trigger foods back into their diet at 9 months, and the resolution of symptoms at 9 and 12 months in infants with multiple food allergies.