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Öğe The effect of ıntravesical prostatic protrusion in patients with benign prostatic hyperplasia: controlled, clinical study(Karger, 2019) Kadıhasanoğlu, Mustafa; Aydın, Mustafa; Taşkıran, Mehmet; Kendirci, MuammerBackground: Although prostate cancer releases more prostate-specific antigen (PSA) per unit of prostate volume (PV), data are limited regarding the association between intravesical prostatic protrusion (IPP) and the PSA level. Objectives: The study aim was to evaluate the IPP effect in patients with benign prostatic hyperplasia. Method: This study included patients with (n = 119) and without (n = 121) IPP. The age, International Prostate Symptom Score (IPSS), PSA level, maximum and average flow rates, PV, hematuria, urinary retention, and post-void residual (PVR) volume were compared between the 2 groups. Results: The mean ages were similar between the 2 groups (66.56 +/- 8.67 and 66.92 +/- 8.7 years, respectively, p = 0.747), and there were no statistically significant differences in the IPSS, maximum and average flow rates, hematuria, PVR volume, and urinary retention means (p > 0.05). However, the IPP patients had lower total PSA (tPSA) and free PSA (fPSA) levels than those without IPP (3.55 [4.18] vs. 5.26 [5.24] ng/mL, p = 0.013 and 0.7 [1.09] vs. 1.05 [1.23] ng/mL, p = 0.029, respectively). Moreover, there were strong positive correlations between the IPP grade and the tPSA and fPSA levels (r = 0.262, p = 0.001 and r = 0.254, p = 0.002 respectively). Conclusions: This study demonstrated that IPP results in a decreased PSA level, even with a higher PV. (C) 2019 S. Karger AG, BaselÖğe The efficacy of mid-urethral sling procedures, transobturator tape and tension-free vaginal tape in the treatment of female stress urinary incontinence: a comparative study of twelve months follow-up after surgery(Istanbul Training & Research Hospital, 2018) Aydın, Mustafa; Karatağ, Tuna; Kadıhasanoğlu, Mustafa; Tanrıverdi, Orhan; Döndar, Çiğdem; Kendirci, MuammerObjective: The aim of the study is to compare the efficacy and safety of tension-free vaginal tape (TVT) and transobturator tape (TOT) procedures in the treatment of female stress urinary incontinence (SUI) in a two-arm study with a 1-year follow-up. Methods: The single-center retrospective study included 73 patients who underwent TVT or TOT between January 2006 and October 2012. Patients who had neurological disease or required surgical repair of cystocele or rectocele were excluded from the study. The primary outcome was treatment efficacy and safety at 12 months, defined by overactive bladder (OAB) scores and self-reported absence of symptoms. For comparisons between the groups, chi-square and Student-t tests were used. Results: Among the women included in the analysis, 52 patients underwent TVT and 21 underwent TOT. The mean age of the patients was 48.9 years in the TOT group and 46.2 years in the TVT group (p=0.713). The patient satisfaction rate was found to be 82.5% in the TOT group and 84.6% in the TVT group (p=0.917); complete dryness rates were similar in both groups (57.5% vs. 58.3%, p=0.817). There was a significant decrease in using pads in both groups, and OAB scores also showed a statistically significant decrease. Conclusion: Tension-free vaginal tape and TOT have similar efficacy as a minimally invasive technique for the treatment of female SUI. The symptoms of urgency urinary incontinence can also be reduced in parallel with OAB scores.Öğe The Efficacy of Mid-Urethral Sling Procedures, Transobturator Tape and Tension-Free Vaginal Tape in the Treatment of Female Stress Urinary Incontinence: A Comparative Study of Twelve Months Follow-Up After Surgery(2018) Kendirci, Muammer; Aydın, Mustafa; Karatağ, Tuna; Döndar, Çiğdem; Tanrıverdi, Orhan; Kadıhasanoğlu, MustafaObjective: The aim of the study is to compare the efficacy and safety of tension-free vaginal tape (TVT) and transobturator tape (TOT) proceduresin the treatment of female stress urinary incontinence (SUI) in a two-arm study with a 1-year follow-up.Methods: The single-center retrospective study included 73 patients who underwent TVT or TOT between January 2006 and October 2012.Patients who had neurological disease or required surgical repair of cystocele or rectocele were excluded from the study. The primary outcomewas treatment efficacy and safety at 12 months, defined by overactive bladder (OAB) scores and self-reported absence of symptoms. Forcomparisons between the groups, chi-square and Student-t tests were used.Results: Among the women included in the analysis, 52 patients underwent TVT and 21 underwent TOT. The mean age of the patients was48.9 years in the TOT group and 46.2 years in the TVT group (p=0.713). The patient satisfaction rate was found to be 82.5% in the TOT groupand 84.6% in the TVT group (p=0.917); complete dryness rates were similar in both groups (57.5% vs. 58.3%, p=0.817). There was a significantdecrease in using pads in both groups, and OAB scores also showed a statistically significant decrease.Conclusion: Tension-free vaginal tape and TOT have similar efficacy as a minimally invasive technique for the treatment of female SUI. Thesymptoms of urgency urinary incontinence can also be reduced in parallel with OAB scores.Öğe Erectile dysfunction and adult onset hypogonadism in leprosy: cross-sectional, control group study(Lepra, 2019) Güler, Haydar; Kadıhasanoğlu, Mustafa; Aydın, Mustafa; Kendirci, MuammerIntroduction: Erectile dysfinction and hypogonadism are associated with advancing age, but may be more prevalent in men affected by leprosy. Methods: This study compared various measures of testicular and sexual function in leprosy patients and age-matched controls. Results: 51 leprosy patients and 55 controls were recruited. Significant differences between the two groups were found in terms of sexual and psychological functioning, and in endocrine status. Conclusion: A greater awareness of how common sexual dysfunction is in male leprosy patients is called for, so that appropriate interventions can be put in place.Öğe Low free and bioavailable testosterone levels may predict pathologically-proven high-risk prostate cancer: a prospective, clinical trial(Aves, 2017) Bayar, Göksel; Şirin, Hakan; Aydın, Mustafa; Özağarı, Ayşim; Tanrıverdi, Orhan; Kadıhasanoğlu, Mustafa; Kendirci, MuammerObjective: To determine the predictive value of free and bioavailable testosterone levels on the detection of high-grade prostate cancer proven by histopathological examination of transrectal prostate biopsy specimens. Material and methods: A total of 405 patients who underwent transrectal prostate biopsy due to high prostatic specific antigen (PSA) (>2.5 ng/mL) and/or abnormal findings at digital rectal examination were included in this study. Blood free and bioavailable testosterone levels were calculated by the formula recommended by International Society for the Study of the Aging Male (ISSAM). The patients were stratified according to the D'Amico classification based on PSA levels and histological outcomes of prostate biopsies as benign, low, intermediate and high-risk prostate cancer. Patients were also divided into five groups according to the percentage of cancerous cores. Results: Prostate cancer was detected in 160 of 405 (39.5%) patients. Total, free and bioavailable testosterone levels did not differ significantly between the patients with benign or malign histology. However, mean free (6.2 vs. 5.2 ng/dL, p=0.02) and bioavailable (151 vs. 125 ng/dL, p=0.001) testosterone levels were found to be significantly different in men with low-intermediate and high-risk prostate cancer. Moreover, a significant correlation was found between free, and bioavailable testosterone levels and percentage of cores with cancer (p=0.002 for free and p=0.016 for bioavailable testosterone, respectively). Conclusion: This prospective clinical study demonstrates that reduced levels of calculated blood free and bioavailable testosterone levels are associated with an increased risk of high-grade prostate cancer. Based on these findings blood free and bioavailable testosterone levels may be be thought to be an adjunctive factor in the prediction of high-risk prostate cancer.Öğe Prevalence of erectile dysfunction in men over 40 years of age in Turkey: results from the Turkish society of andrology male sexual health study group(Aves, 2017) Çayan, Selahittin; Kendirci, Muammer; Yaman, Önder; Aşçı, Ramazan; Orhan, İrfan; Usta, Mustafa Faruk; Kadıoğlu, AteşObjective: Previous study conducted by the Turkish Society of Andrology in 1999 reported the prevalence of erectile dysfunction (ED) as 69.2% in men of >= 40 years of age, using a single-item non-validated question. This rate seemed to be higher compared to the studies reported worldwide. So, there was a need to carry out another epidemiological study by using validated questionnaires. Our aim was to investigate ED prevalence, severity, and its correlates in men aged >= 40 years using validated tools. Material and methods: This cross-sectional, observational, population-based field survey was carried out in randomly selected males of >= 40 years from 19 provinces of Turkey. All participant completed a survey included with socio-demographic and socio-economic characteristics, medical and sexual history, associated physical and medical comorbidities. Erectile function was assessed by the International Index of Erectile Function (IIEF) questionnaire based on a total score of 30. The prevalence of ED, its severity and correlates in men aged >= 40 years were determined for main outcome measures. Data sets were statistically compared and p<0.05 was considered as significant. Results: Median age of 2.760 males was 54.2 years. The median prevalence of ED was calculated as 33% among all males of >= 40 years of age. When subjects were stratified by age; median ED prevalence rates were 17% for 40-49 years, 35.5% for 50-59 years, 68.8% for 60-69 years, and 82.9% for >= 70 years. Among all ED men, 76.9% reported mild, 16.3% moderate, and 5.7% severe ED. At logistic regression analyses; age, diabetes, hypertension, atherosclerosis, dyslipidemia, lower urinary tract symptoms, educational status and monthly income were found to be independent risk factors for having ED. Conclusion: This population-based survey in Turkish men of >= 40 years of age reported the prevalence of ED as 33%. Besides, this study reported age as the main predictor for presence and severity of ED.Öğe Relation between blood vitamin B12 levels with premature ejaculation: case-control study(Wiley, 2017) Kadıhasanoğlu, M.; Kilciler, M.; Kilciler, G.; Yücetaş, U.; Erkan, E.; Karabay, E.; Toktaş, M. G.; Kendirci, MuammerThe aim of this study was to investigate whether vitamin B12 levels are associated with premature ejaculation (PE). A total of 109 subjects (56 PE and 53 controls) were included in this study. PE was defined as self-reported intravaginal ejaculatory latency time (IELT) based on the Diagnostic and Statistical Manual of Mental Disorders IV criteria and those who had had an IELT of <2min was considered as PE. All participants were evaluated using premature ejaculation diagnostic tool (PEDT), International Index of Erectile Function (IIEF) and Beck Depression Inventory (BDI). The vitamin 12 levels were measured in all subjects. The mean age between the PE and controls was comparable (p=.084). Mean IIEF and BDI scores between the two groups did not statistically differ. The mean IELT values in the PE group were significantly lower than in the control group (p<.0001). PE patients reported significantly lower vitamin B12 levels compared with the controls (213.14 vs. 265.89ngml(-1); p<.001). The ROC analysis showed a significant correlation between the diagnosis of PE and lower vitamin B12 levels. This study has demonstrated that lower vitamin B12 levels are associated with the presence of PE. This work also shows a strong correlation between vitamin B12 levels and the PEDT scores as well as the IELT values.Öğe Testosterone replacement therapy and cardiovascular events(Turkish Soc Cardiology, 2017) Çatakoğlu, Alp Burak; Kendirci, MuammerA low testosterone level and hypogonadism are associated with cardiovascular disease. Aging, chronic health problems, and obesity are all associated with a low testosterone level as well as the presence and severity of cardiovascular disease. Testosterone is increasingly prescribed for patients with clinical hypogonadism and a low testosterone level. The information we have is still contradictory regarding testosterone replacement therapy (TRT) and its association with adverse cardiovascular events. Older patients and patients who are susceptible to cardiovascular diseases could be at risk with a testosterone prescription. This is a review of the literature to discuss the cardiovascular safety of TRT.
