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    Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
    (2022) Savani, Samira; Onbaşlı, Kübra; Gündüz, Eren; Aydındoğan, Eda; Erkısa, Merve; Muti, Abdullah; Khan, Minahil; Sennaroglu, Alphan; Ulukaya, Engin; Yağcı Acar, Havva; Kölemen, Safacan
    A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.