Yazar "Noyan, Handan" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1 beta levels in patients with schizophrenia spectrum disorder and their siblings
    (ELSEVIER, 2021) Noyan, Handan; Erdağ, Ece; Tüzün, Erdem; Yaylim, Lhan; Küçükhüseyin, Özlem; Hakan, Mehmet Tolgahan; Gülöksüz, Sinan; Rutten, Bart P. F.; Saka, Meram Can; Atbaşoğlu, Cem; Alptekin, Köksal; Van Os, Jim; Uçok, Alp
    Objective: There is evidence suggesting that tryptophan (TRP)-kynurenine (KYN) pathway dysregulation is involved in the pathophysiology of schizophrenia and is regulated by inflammatory cytokines. The study investigate for the first time whether this dysregulation occurs in advanced stages of the disease as a byproduct or emerges as one of the early and inherited manifestations of schizophrenia. Method: Sera of 148 patients with schizophrenia spectrum disorders (SCZ), 139 unaffected siblings (SIB) and 210 controls were investigated. Serum interleukin (IL)-1 beta levels were measured by ELISA, and TRP, KYN and kynurenic acid (KYNA) levels were measured by a high-performance liquid chromatography system. Also, we collected clinical data by applying Comprehensive Assessment of Symptoms and History in SCZ, and SIS-R in SIB and control groups. Results: Compared to controls, SCZ and SIB groups had lower TRP and higher KYNA levels. TRP levels showed significant differences only between SCZ and controls (p < 0.01). KYNA levels of both SCZ (p <_ 0.001) and SIB (p < 0.05) were higher than controls. No statistical significance was found for KYN levels across groups. SCZ and SIB groups had higher serum IL-1 beta levels than controls (p <_ 0.001). Conclusions: Patients with SCZ and their siblings exhibited similar clinical features and TRP metabolite levels suggesting that TRP-KYN dysregulation may be an inherited component of the disease putatively conferring increased risk to schizophrenia. Elevation of IL-1 beta is one of the factors promoting overconsumption of the TRP-KYN pathway leading to increased production of neuroregulatory KYNA and presumably to neurodegeneration. (c) 2021 Elsevier B.V. All rights reserved.
  • Küçük Resim
    Öğe
    Effects of menstural cycle on resting state functional coonectivity in schizophrenia: a functional MRI study
    (Oxford Univ Press, 2020) Noyan, Handan; Hamamci, Andac; Firat, Zeynep; Oygen, Aysegul Sarsilmaz; Ucok, Alp
    Background: Negative symptoms are core contributors to social deficits in psychosis. However, currently available interventions do not significantly ameliorate negative symptoms or social outcomes in individuals at Clinical High Risk of Psychosis (CHR-P). Given its critical role in human social behaviour and cognition, the oxytocin (OT) system is a promising target for the treatment of social impairments in CHR-P subjects.
  • Küçük Resim
    Öğe
    Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra-high risk for psychosis
    (Blackwell Publishing, 2020) Ucok, Alp; Direk, Nese; Kaya, Hatice; Caglar, Nuran; Cikrikcili, Ugur; Noyan, Handan; Yokusoglu, Cagdas; Devrim-Ucok, Muge
    Aim: Negative symptoms and cognition are related with functioning in schizophrenia. However, it is not clear whether they have a similar effect in individuals at ultra-high risk (UHR) for psychosis. In this study, we aimed to explore relationship of negative symptoms with cognition and functioning cross-sectionally in people with UHR for psychosis. Methods: In total, 107 people participated in this study. We assessed negative symptoms with Scale for Negative Symptoms (SANS). We applied a cognitive battery including seven tests. We evaluated functioning by using Global Assessment of Functioning Scale and work/study status as an indicator of role functioning. Results: SANS scores were correlated to global functioning cross-sectionally. SANS total score was correlated to cognitive test scores related to cognitive flexibility and attention. Only Trail Making Test B (TMT B) was negatively correlated to global functioning. SANS-affective blunting and SANS-avolition scores were independently related to global functioning. There was a significant indirect effect of the TMT B and composite attention scores on global functioning through negative symptoms indicating a complete mediation. Conclusion: Our findings suggest that negative symptoms, particularly avolition have an impact on functioning and the association of cognition with functioning was mediated by negative symptoms in UHR. © 2020 John Wiley & Sons Australia, Ltd