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Öğe Accuracy of multi-echo dixon sequence in quantification of hepatic steatosis(Cureus Inc, 2020) Yurdaışık, Işıl; Nurili, FuadObjective Today, a biopsy is the gold standard in the diagnosis of non-alcoholic fatty liver. However, a biopsy is an invasive technique, limited to the sample taken, and it may lead to misdiagnosis. Therefore, novel noninvasive options are needed. The objective of this study was to investigate the accuracy of magnetic resonance (MR) Dixon sequence and elastography using magnetic resonance spectroscopy (MRS) as a reference in the quantification of hepatic steatosis. Methods A total of 60 patients were included in the study. All patients underwent magnetic resonance imaging (MRI), MRS, and elastography in order to quantify hepatosteatosis. MRI and MRS imaging studies were performed using MR Dixon and high-speed T2-corrected multiple-echo 1H-MRS sequence (HISTO) sequences, respectively, in order to calculate proton density fat fraction (PDFF) values. Results The mean MRI-PDFF value with the MRS region of interest (ROI) was found as 9.4% +/- 12.1%. The mean MRS-PDFF was found as 8.9% +/- 11.3%. No statistically significant difference was found between MRS-PDFF and MRI-PDFF values measured in ROI (p < 0.005). The correlation between MRS-PDFF and MRI-PDFF was examined with Spearman's correlation analysis. Accordingly, there was an excellent correlation between MRS and MRI values measured in ROI (r = 0.8, p < 0.001). Sensitivity, specificity, positive predictive value, and negative predictive value were calculated as 96%, 100%, 89.5%, and 92.6%, respectively, for MRI-PDFF in predicting hepatic steatosis for the same ROI localization with MRS. The optimum cut-off value of MRS-PDFF in predicting hepatic steatosis was found as 5.3% using the same ROI localization with MRS. Conclusion The results of this study indicated an excellent correlation between MRI-PDFF and MRS-PDFF. The multi-echo Dixon MRI technique seems a promising alternative method in the detection of non-alcoholic fatty liver disease.Öğe Catheter-directed gastric artery embolization with octreotide acetate loaded PLA/PLGA (poly[lactide-co-glycolide] acid) microspheres with slow sustained-release properties suppresses the plasma concentration of ghrelin, which results in weight loss(Science Direct, 2019) Nurili, Fuad; Acar, T.; Derman, S.; Baş, A.; Caymaz, I.; Özkanlı, S.; Çakıroğlu, H.; Yurdaışık, Işıl; Aras, O.Purpose: The objective of the present work was to formulate slow- and sustained-release octreotide acetate-loaded PLA/PLGA (polylactide)(poly (Lactic-co- Glycolic) acid) microspheres and prospectively test the effects of catheter-directed gastric artery administration of these microspheres on plasma ghrelin levels and body weight in swineÖğe Evaluation of chest CT findings in 50 Coronavirus disease 2019 (COVID-19) patients treated in Turkey(CUREUS INC, 2020) Yurdaışık, Işıl; Nurili, FuadAbstract Objectives The objective of this study was to evaluate chest CT outcomes during the treatment of 50 coronavirus disease 2019 (COVID-19) patients treated in Turkey who presented with symptoms such as fever, cough, and dyspnea, and to analyze these results in line with the current literature. Methods Patients' demographic data such as age and gender, symptoms on admission, contact history, comorbidities, and PCR and CT outcomes were recorded and analyzed. In CT examinations, laterality, the presence of consolidation and/or ground-glass opacities (GGO), and central and/or peripheral distribution were analyzed. In addition, segmental analysis was performed with CT results. Results In CT scans, involvement was found at the right lung in 10 (20%) patients and left lung in 1 (2%) patient, whereas bilateral involvement was found in 39 (78%) patients. Peripheral distribution was found in 18 (36%) patients and central + peripheral distribution in 28 (56%) patients. Density of the lesions was GGO in 44 (88%), whereas consolidation + GGO was found in 6 (12%) patients. The mean number of involved segments was 6.92 +/- 6.74 (min-max: 1-20). There was a significant correlation between the involvement of the R3 segment and fever (r = 0.288; p = 0.042). Conclusions Typical COVID-19 patterns on chest CT were GGO, bilateral involvement, peripheral, and central + peripheral distribution. Our results indicate that chest CT may be helpful in diagnosing the disease and monitoring its progression. However, since clinical pictures of COVID-19 may differ, CT outcomes should be carefully interpreted.Öğe Evaluation of the correlation between breast artery calcification and coronary artery calcium scores in predicting the risk for cardiovascular disease(2020) Yurdaışık, Işıl; Nurili, FuadAim: Coronary artery calcium (CAC) score is a scoring system used in the stratification of coronary risks. Breast artery calcification (BAC) is a type of medial artery calcification that can be visualized using mammography and is also known as arteriosclerosis. It has been reported that a significant correlation exists between BAC and CAC and that the presence of BAC improves the ability of detecting women with CAC. This study aimed to evaluate the relationship between mammographically-detected BAC and CAC. Materials and Methods: A total of 31 patients who presented to our hospital for diagnostic or screening mammography and who underwent CAC scoring between 2015 and 2018 were included in the study. Agatston method was used to determine the CAC score. Total BAC, which varies from 0 to 12, was measured based on the number and length of calcified vessels and the severity of mammographically-visualized calcification. Results: The mean BAC scores were found to be 0 in 1 patient, 1-3 in nine patients and 4-12 in 21 patients. The mean CAC scores were found to be 0 in eight patients, 11-100 in 12 patients, 101-400 in eight patients and >400 in three patients. There was a statistically significant positive correlation between the BAC and CAC scores. Conclusion: This study revealed a positive correlation between the BAC and CAC scores. It was found that mammographic calcification scoring, which is already commonly used as a screening tool and is more advantageous than tomography, can be used for the early determination of intermediate risk groups for cardiovascular diseases.Öğe Novel magnetic embolic MRI imageable particles with anticancer drug release for transcatheter arterial embolization and magnetic ablation(WILEY, 2022) Bekaroğlu, Maide Gökçe; Nurili, Fuad; Caymaz, İsmail; Baş, Ahmet; İşçi, SevimThe aim of the study is to prepare embolic hydroxyl ethyl cellulose (HEC)-polyvinyl prolidone (PVP)-magnetic particles suitable for transcatheter arterial chemoembolization (TACE) procedures, drug delivery, and magnetic hyperthermia. Two different sizes (microsized and nanosized) of iron oxide particles were used to prepare the embolic particles to investigate the embolization and drug delivery properties. Iron oxides were linked with PVP via bridging flocculation process, then outermost layer of the linked particles was coated with HEC in order to load drugs to particles and reach size requirements for a successful TACE procedure. Size of each particle was calibrated to the range that allows easy injections through microcatheters (40-500 mu m). The results showed that the size of the final embolic particles reached around 70 mu m with 82 W/g specific absorption rate (SAR) values for nano-iron oxide particles and 45 mu m with 77 W/g SAR values for micro-iron oxide particles, which are quite suitable for TACE applications. Furthermore, an anticancer drug doxorubicin (DOX) was successfully loaded onto these particles in order to achieve localized chemotherapy at the tumor site. Particles produced in this study, loaded DOX successfully and prolonged drug release time, performed similarly to pure DOX at higher concentration treatments against human breast cancer cell lines, were heatable under applied alternating magnetic fields. In addition, in vivo embolization studies performed using a rabbit renal embolization model, indicated that these particles were easily delivered through microcatheters and were able to embolize the target.Öğe Postmortem biopsies of the lung, heart, liver, and spleen of COVID-19 patients(CUREUS INC, 2021) Yurdaışık, Işıl; Demiröz, Ahu S.; Öz, Aysim B.; Akker, Mustafa; Ağırman, Ayşegül; Aksoy, Süleyman Hilmi; Nurili, FuadObjective We aimed to evaluate histopathologic alterations in the lung, heart, liver, and spleen of coronavirus 2019 (COVID-19) decedents through postmortem core needle biopsies. Materials and methods Patients who died of reverse transcription-polymerase chain reaction-proven COVID-19 were this postmortem case series. Postmortem percutaneous ultrasound-guided biopsies of the lungs, and spleen were performed using 14-and 16-gauge needles. Biopsy samples were stained with eosin and examined under a light microscope. Clinicodemographic characteristics, chest computed tomography (CT) images, and COVID-19-related treatments of the patients were also collected. Results Seven patients were included in this study. Liver and heart tissue samples were available from all and lung and spleen tissue samples were available from five and three patients, respectively. Chest images predominantly revealed bibasilar ground-glass opacities. Lung biopsies showed diffuse damage in all biopsy specimens. Heart findings were nonspecific and largely compatible with the disease. Patchy necrosis, steatosis, and mononuclear cell infiltration were the main findings in biopsies. Splenic histopathological examination showed that splenic necrosis and neutrophil infiltration were common findings in all patients. Conclusion Tissue acquisition was complete for the heart and liver and acceptable for the lungs. The amount was sufficient for a proper histopathologic examination. Histopathological findings were generally accordance with previous autopsy studies. Radiological findings of the lung were also correlated histopathologic findings. We consider that a postmortem biopsy is a feasible alternative for histopathological examinations in COVID-19 decedents.
