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    Antibacterial and anthelmintic effect of the combination of pomegranate peel and olive leaf extracts
    (Istanbul Medipol University, 2023) Alparslan, L.; Giray, B.; Gulec, M.; Kaya, N.; Uvey, D.; Olgun, A.
    Pomegranate peel and olive leaf are known to have antibacterial activity. These two plants have been studied in various studies. However, there is no study on the synergistic effect of these two plants. In this study, the antibacterial activity of a supplement containing pomegranate peel and olive leaf extracts against S. mutans and its antihelmintic activity against C. elegans were determined. Results obtained by the disk diffusion method and microdilution test are 12.5 mm and ? 1024 ?g/ mL, respectively. Anthelmintic activity experiments revealed that the lifespan of worms was shortened as a result of the synergistic effect of the extracts. Our results revealed the synergistic effect of these two extracts against the microbes and possible helminths in the oral flora. Increasing antibiotic resistance has led researchers to work on the detection of new plant extracts and substances. It is aimed that this study on plant extracts will help future studies. © 2023, Istanbul Medipol University. All rights reserved.
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    Cedrus libani A. Rich
    (Springer International Publishing, 2022) Güleç, M.; Kiremitci, S.A.; Olgun, A.
    Cedrus is a vital member of the Pinaceae family, with elegant, decorative, evergreen, high, and monoecious conifer members that grow widely on mountains, particularly in the South, Southeast Mediterranean, and Western Himalaya. Cedrus libani (A. Rich), one of the four species, is currently found in only a few locations around the Eastern Mediterranean. It is a biologically significant species with one of the earliest ethnobotanical values in history of mankind, and it still attracts attention due to the ethnobotanical uses prevalent in its expanding range. Numerous studies on various parts of Cedrus libani shed light on its chemical composition (mostly terpenic structures) and pharmacological properties (anti-diabetic, antimicrobial, wound healing, and cytotoxic activities); however, there are undoubtedly many more discoveries to be made with further studies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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    Urinary trehalase activitiy in contrast- associated acute kidney injury
    (Verduci Publisher, 2023) Kovanci, B.; Dogan, H.; Olgun, A.; Kural, A.; Yigit, Y.; Neijman, S. T.
    OBJECTIVE: Contrast -associated acute kidney injury (CA-AKI) is the third most common cause of hospital-acquired AKI. Sensitive biomarkers can detect kidney injury early on because kidney damage begins immediately after the administration of a contrast medium. Due to its proximal tubule specificity, urinary trehalase can be a useful and early marker for detecting tubular damage. This study aimed to reveal the power of urinary trehalase activity in diagnosing CA-AKI.PATIENTS AND METHODS: This is a prospective, observational, and diagnostic validity study. The study was performed in an academic research hospital's emergency department. Patients aged 18 years and over who underwent contrast-enhanced computed tomography in the emergency department were included in the study. Urinary trehalase activities were measured before and 12, 24, and 48 hours after the administration of a contrast medium. The primary outcome was the occurrence of CA-AKI, while the secondary outcomes were risk factors for CA-AKI, duration of hospital stay after contrast use, and the mortality rate in the hospital.RESULTS: A statistically significant difference between the CA-AKI group and the non-AKI group was found in the activities measured 12 hours after the administration of the contrast medium. Notably, the mean age of the patient group with CA-AKI was considerably higher than that of the non-AKI group. The risk of mortality was found to be remarkably more ele-vated in patients with CA-AKI. Further, there was a positive correlation between trehalase activity and HbA1c. In addition, a crucial correlation was found between trehalase activity and poor glycemic control.CONCLUSIONS: Urinary trehalase activity can be useful as a marker of acute kidney injuries due to proximal tubule damage. In the diagnosis of CA-AKI, especially the activity of trehalase in the 12th hour might be useful.
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    Urinary trehalase activitiy in contrast-associated acute kidney injury
    (Verduci Editore s.r.l, 2023) Kovanci, B.; Dogan, H.; Olgun, A.; Kural, A.; Yigit, Y.; Neijman, S.T.
    OBJECTIVE: Contrast-associated acute kidney injury (CA-AKI) is the third most common cause of hospital-acquired AKI. Sensitive biomarkers can detect kidney injury early on because kidney damage begins immediately after the administration of a contrast medium. Due to its proximal tubule specificity, urinary trehalase can be a useful and early marker for detecting tubular damage. This study aimed to reveal the power of urinary trehalase activity in diagnosing CA-AKI. PATIENTS AND METHODS: This is a prospective, observational, and diagnostic validity study. The study was performed in an academic research hospital’s emergency department. Patients aged 18 years and over who underwent contrast-enhanced computed tomography in the emergency department were included in the study. Urinary trehalase activities were measured before and 12, 24, and 48 hours after the administration of a contrast medium. The primary outcome was the occurrence of CA-AKI, while the secondary outcomes were risk factors for CA-AKI, duration of hospital stay after contrast use, and the mortality rate in the hospital. RESULTS: A statistically significant difference between the CA-AKI group and the non-AKI group was found in the activities measured 12 hours after the administration of the contrast medium. Notably, the mean age of the patient group with CA-AKI was considerably higher than that of the non-AKI group. The risk of mortality was found to be remarkably more elevated in patients with CA-AKI. Further, there was a positive correlation between trehalase activity and HbA1c. In addition, a crucial correlation was found between trehalase activity and poor glycemic control. CONCLUSIONS: Urinary trehalase activity can be useful as a marker of acute kidney injuries due to proximal tubule damage. In the diagnosis of CA-AKI, especially the activity of trehalase in the 12th hour might be useful. © 2023 Verduci Editore s.r.l. All rights reserved.