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    Demographic, clinical, and laboratory characteristics of elderly onset psoriatic arthritis
    (Bmj Publishing Group, 2017) Kobak, Şenol; Orman, Mehmet Akif
    Background: Psoriatic arthritis (PsA) is a chronic in?amatory disease characterized with axial and peripheral joints involvement. It is rarely affects patients older than 65 years old. Objectives: The purpose of this study is to compare and evaluate the demographic,clinicalandlaboratoryfeaturesofelderly-onsetpsoriaticarthritis(EOPsA) and young-onset (YOPsA) patients. Methods: One hundred and eighty patients diagnosed with PsA according to CASPAR criteria and followed-up in single center were included in this study. The patients with initial symptoms started after age 65 were accepted as EOPsA. Demographic,clinical,andlaboratorydataandthemedicationswhichthepatients recieved were recorded and retrospectively evaluated. Results: Nineteen (10.5%)of 180 patients were diagnosed as EOPsA, and 161 (89.5%) patients were evaluated as YOPsA. Mean patient age was 42.1years for YOPsA group and 68.3years for elderly onset group. Mean duration of disease was 5.6 years for early onset group and 1.3 years for elderly onset group (p=0.001). Fourteen (73.3%) of 19 EOPsA patients were female and 5 of them were male. Higher rates of fatique, pain scores, comorbid diseases and acute phase reactants were detected in EOPsA patients comparing to YOPsA (p=0.000, p=0.000, p=0.001 and p=0.001 respectively). YOPsA patients have more dactilitis, nail involvement, elevated PASI scores, and smoking habitus when comparedwithEOPsApatients(p=0.019,p=0.03,p=0.005,p=0.004respectively). In terms of the treatment options chosen, there was no signi?cant difference in the use of non-steroidal anti-in?ammatory drugs (NSAIDs), corticosteroids (CS), methotrexate (MTX), and sulfasalazine (SSL), but there was a more frequent use of anti-tumor necrosis factor -alpha in YOPsA group. Conclusions: Herein we showed that YOPsA and EOPsA patients may have different demographic, clinical, and laboratory features. EOPsA patients are characterized with higher rates of fatique, pain scores, comorbid diseases, and acute phase reactants and less dactilitis, nail involvement and anti-TNF-alpha usage.
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    Elderly - onset sarcoidosis: a single center comparative study
    (Ediciones Doyma, S.L., 2020) Kobak, Şenol; Yıldız, Fidan; Semiz, Hüseyin; Orman, Mehmet Akif
    Objectives: Sarcoidosis rarely affect patients older than 65 years old. The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset (EOS) and young-onset sarcoidosis (YOS) patients. Methods: One hundred and thirty one patients diagnosed with sarcoidosis according to clinical, radiologic and histopathological evaluation were included in this study. The patients with initial symptoms started after age 65 were accepted as EOS. Results: Twenty (15.3%) of 131 patients were diagnosed as EOS, and 111 (84.7%) patients were evaluated as YOS. Fifteen of 20 EOS patients were female and 5 of them were male. Average duration of the disease was determined as 38.4 months for YOS and 22.5 months for EOS (p = 0.556). Delay of the diagnosis was 12 months for YOS while it was 3 months for EOS (p = 0.001). Higher rates of fatique, comorbid diseases and more hydroxychloroquine (HQ) use were detected in EOS patients comparing to YOS (p = 0.010, p = 0.003 and p = 0.039 respectively). Conclusions: EOS patients are characterized with higher rates of fatique and comorbid diseases, less inflammatory sign and delayed diagnosis, and less DMARDs use. © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
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    Elderly - onset sarcoidosis: a single center comparative study
    (Bmj Publishing Group, 2017) Kobak, Şenol; Sever, Fidan; Semiz, Hüseyin; Orman, Mehmet Akif
    Sarcoidosis is a chronic granulomatous inflamatory disease characterized with non-caseified granuloma formation. It is rarely affects patients older than 65 years old.
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    Malignancy in patients with sarcoidosis: a retrospective cohort study from Turkey
    (Bmj Publishing Group, 2018) Kobak, Şenol; Yıldız, Figen; Semiz, Hüseyin; Orman, Mehmet Akif
    The relationship between sarcoidosis and malignancy is not clear yet. There is debate with different speculations in the literature in this regard, that this association may be just a coincidence and/or common pathogenetic link. Objectives: The goal of our study was to evaluate the incidence and characteris-tics of malignancy in patients with sarcoidosis follow-up in a single centre.