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    Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review
    (Wiley, 2024) Ebrahimi, Aliakbar; Icoz, Kutay; Didarian, Reza; Shih, Chih-Hsin; Tarim, E. Alperay; Nasseri, Behzad; Akpek, Ali
    Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. Lab-on-a-chip systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, lab-on-a-chip methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques. This review is about the microfludic-based methods that have been used in the past two decades for the separation of different biomolecules like protein, DNA, and RNA. In this regard, passive, active, and hybrid microfludic methods that are used for biomolecules separation are disscused and reviewed in this paper.image