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    The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches
    (Editions de Sante, 2022) Bal Öztürk, Ayça; Alarçin, Emine; Özbaş, Zehra; Özkahraman, Bengi; Torkay, Gülşah
    In this research, the effect of thiol functional groups on bovine serum albumin (BSA)/chitosan (Chi) based buccal mucoadhesive patch was investigated. Thiolated BSA (BSA-SH) was prepared via 2-mercaptoethanol. FTIR and 1H NMR results confirmed that BSA-SH was synthesized successfully. The buccal mucoadhesive patches were fabricated by the solvent casting method. Following the structural characterization of BSA/Chi and BSA-SH/Chi buccal patches, the mechanical characterization was performed by tensile tests. The drug release from triam- cinolone acetonide (TR) loaded buccal patches was evaluated in-vitro in simulated salivary. According to the ex- vivo buccal adhesion experiments, the mechanical and mucoadhesion properties of BSA-SH/Chi buccal patch had improved compared to BSA/Chi buccal patch. The total cumulative TR permeated after 12 h was higher for BSA- SH/Chi than BSA/Chi buccal patches. The developed mucoadhesive buccal patches were found to be biocom- patible in vitro. To conclude, the thiolated BSA-SH/Chi buccal adhesive patch is a promising biomaterial for a satisfied drug delivery, which provides advantages for various oral applications.
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    The effect of vitamin c in the formulation of pectin/thiolated alginate buccal adhesive patches: in vitro and ex vivo evaluation
    (Elsevier Ltd., 2022) Özkahraman, Bengi; Torkay, Gülşah; Özbaş, Zehra; Bal Öztürk, Ayça
    The present study outlines the prospect of a pectin (Pec)/modified alginate (Alg) buccal patch as drug delivery device in the localized treatment of oral cavity diseases. Firstly, Alg was modified with acrylic acid, and thiolated with cystein to enhance its mucoadhesive properties. Then modified Alg was characterized with Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1HNMR) spectroscopy. As a proof of concept, Pec/modified Alg buccal patches were formed via the conventional solvent casting technique. Then the patches were characterized by FTIR and differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA). Vitamin C (Vit C) was used for in vitro drug release assay, and the release amount was 2.10 mg/g polymer in simulated salivary pH 6.8. Ex vivo mucoadhesion assays of Vit C loaded Pec/modified Alg patch did not have a negative effect on the mucoadhesion feature of the material. The cytotoxicity study indicated that Pec/modified Alg buccal patches did not exhibit apparent cytotoxicity against NIH/3T3 cell lines. Notably, it was found that Vit C in the patch formulation has an accelerating effect on wound healing. According to all results, Vit C loaded Pec/modified Alg buccal patch might be a promising candidate for localized buccal drug release systems.
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    Preparation of quercetin incorporated photocrosslinkable methacrylated gelatin/methacrylated kappa-carrageenan antioxidant hydrogel wound dressings
    (SPRINGER INT PUBL AG, 2022) Özbaş, Zehra; Torkay, Gülşah; Bal Öztürk, Ayça; Özkahraman, Bengi
    Wound dressings with antioxidant potential have attracted remarkable concerns for wound healing. The purpose of this work is to investigate blank, and quercetin loaded photocrosslinkable methacrylated gelatin (GelMA)/methacrylated kappa-carrageenan (KapMA) hydrogel. Wound dressings were produced by the photocrosslinking method in the presence of a photoinitiator. Quercetin was incorporated in photocrosslinkable GelMA/KapMA wound dressings with different ratios. Besides, Fourier Transform Infrared Spectroscopy, thermal gravimetric analysis, swelling, and degradation tests were performed for characterization studies of the hydrogel wound dressings. The release of quercetin from GelMA/KapMA wound dressings was investigated at a physiological pH value of 7.4 at 37 degrees C. The antioxidant activity of the hydrogel dressings was further evaluated by 2,2-diphenyl-1-picrylhydrazyl method. Biocompatibility of wound dressings was assessed using MTT assay tests on NIH-3T3 cell line, which evaluated its suitability in biomaterial applications. The obtained results indicated that quercetin incorporated photocrosslinked GelMA/KapMA wound dressings provide antioxidant activity, and they could be the ability for the potential wound dressings applications.