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    Choroidal structural changes in patients with early diabetic nephropathy
    (Elsevier, 2023) Isik, Burcu; Suleymanzade, Metin; Cengiz, Mahir; Yavuzer, Serap; Islamoglu, Mehmet Sami; Uysal, Betul Borku; Harmankaya, N. Ozlem
    Purpose: To determine alterations of the choroidal thickness (CT) and the choroidal vascularity index (CVI) in patients with glomerular hyperfiltration, a marker of early diabetic nephropathy (DN).Methods: Twenty-two patients with type 2 diabetes (T2D) with glomerular hyperfiltration (early DN group) and 28 patients with T2D without DN (NDN group) were included in the study. Patients with diabetic retinopathy were excluded. Parameters including subfoveal CT, the subfoveal choroidal vascularity index (CVI), and total CVI were measured using spectral-domain enhanced depth imaging optical coherence tomography method.Results: The early DN group included 22 patients and the NDN group comprised 28 patients. The groups were similar in terms of age and sex (p>0.05). The CT values were statistically significantly lower in the early DN group than in the NDN group (p < 0.001). There was no significant difference between the early DN group and the NDN group in terms of total and subfoveal CVI (p>0.05).Conclusion: The choroidal thickness decreased in patients with T2D with glomerular hyperfiltration, but there were no differences in CVI when they were compared with patients with T2D without DN.
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    The OGG1 Ser326Cys polymorphism and its association with DNA damage and DNA repair in papillary thyroid cancer
    (Hayat Sağlık ve Sosyal Hizmetler Vakfı, 29 Ocak 2025) Engin, Çağlayan Akkaya; Yavuzer, Hakan; Teksöz, Serkan; Soylu, Selen; Mete, Meltem; Yavuzer, Serap; Tuz, Ali Ata; Güven, Mehmet; Dincer, Yıldız
    Aim: Hydrogen peroxide, locally produced during thyroid hormone synthesis, leads to oxidative stress in the thyroid gland. Defective repair of oxidative DNA lesions contributes to tumor development. This study aimed to understand the importance of DNA damage and repair on thyroid cancer development through the impact of the DNA repair gene OGG1 Ser326Cys polymorphism that has clinical significance in untreated patients with papillary thyroid cancer. Methods: The study was performed with 70 patients with papillary thyroid cancer and 73 volunteers as control. In lymphocytes, endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair were determined by comet assay. The polymerase chain reaction-restriction fragment length polymorphism method was performed for OGG1 genotyping. Results: Endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair were higher in patients with thyroid cancer than in the controls (P<0.001). An association was determined between the OGG1 Cys326 allele and increased risk for the development of papillary thyroid cancer. No significant difference was determined between cases carrying different OGG1 genotypes for endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair in the study groups. Conclusions: Endogenous DNA damage and cell susceptibility to oxidation increase, and DNA repair is impaired in patients with papillary thyroid cancer. However, the OGG1 Ser326Cys polymorphism is not responsible for the DNA repair defect.