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Öğe Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic(Elsevier B.V., 2022) Mostafavi, E.; Zarepour, A.; Barabadi, H.; Zarrabi, A.; Truong, L.B.; Medina-Cruz, D.The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different strategies that have been explored, nanotechnology appears to be a promising and effective approach for therapeutics. Specifically, biogenic silver and gold nanoparticles (NPs) have attracted significant attention for their antineoplastic activity toward leukemia cancer cells due to their unique physicochemical properties. Indeed, these nanostructures have emerged as useful approaches in anti-leukemic applications, either as carriers to enhance drug bioavailability and its targeted delivery to a specific organ or as a novel therapeutic agent. This review explores recent advances in green synthesized nanomaterials and their potential use against leukemia, especially focusing on silver (Ag) and gold (Au) nanostructures. In detail, we have reviewed various eco-friendly methods of bio-synthesized NPs, their analytical properties, and toxicity effects against leukemic models. This overview confirms the satisfactory potency of biogenic NPs toward leukemic cells and desirable safety profiles against human native cells, which opens a promising door toward commercializing these types of nontherapeutic agents if challenges involve clinical validations, reproducibility, and scalability could be resolved. © 2022Öğe Catalytic and biomedical applications of nanocelluloses: A review of recent developments(Elsevier B.V., 2024) Khorsandi, D.; Jenson, S.; Zarepour, A.; Khosravi, A.; Rabiee, N.; Iravani, S.; Zarrabi A.Nanocelluloses exhibit immense potential in catalytic and biomedical applications. Their unique properties, biocompatibility, and versatility make them valuable in various industries, contributing to advancements in environmental sustainability, catalysis, energy conversion, drug delivery, tissue engineering, biosensing/imaging, and wound healing/dressings. Nanocellulose-based catalysts can efficiently remove pollutants from contaminated environments, contributing to sustainable and cleaner ecosystems. These materials can also be utilized as drug carriers, enabling targeted and controlled drug release. Their high surface area allows for efficient loading of therapeutic agents, while their biodegradability ensures safer and gradual release within the body. These targeted drug delivery systems enhance the efficacy of treatments and minimizes side effects. Moreover, nanocelluloses can serve as scaffolds in tissue engineering due to their structural integrity and biocompatibility. They provide a three-dimensional framework for cell growth and tissue regeneration, promoting the development of functional and biologically relevant tissues. Nanocellulose-based dressings have shown great promise in wound healing and dressings. Their ability to absorb exudates, maintain a moist environment, and promote cell proliferation and migration accelerates the wound healing process. Herein, the recent advancements pertaining to the catalytic and biomedical applications of nanocelluloses and their composites are deliberated, focusing on important challenges, advantages, limitations, and future prospects. © 2024 The AuthorsÖğe Inspired by nature: Bioinspired and biomimetic photocatalysts for biomedical applications(KeAi Communications Co., 2024) Bigham, A.; Zarepour, A.; Safarkhani, M.; Huh, Y.; Khosravi, A.; Rabiee, N.; Iravani S.The field of photocatalysis has witnessed a significant advancement in the development of bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, and bioimaging. Nature has evolved efficient light-harvesting systems and energy conversion mechanisms, which serve as a benchmark for researchers. However, reproducing such complexity and harnessing it for biomedical applications is a daunting task. It requires a comprehensive understanding of the underlying biological processes and the ability to replicate them synthetically. By utilizing light energy, these photocatalysts can trigger specific chemical reactions, leading to targeted drug release, enhanced tissue regeneration, and precise imaging of biological structures. In this context, addressing the stability, long-term performance, scalability, and cost-effectiveness of these materials is crucial for their widespread implementation in biomedical applications. While challenges such as complexity and stability persist, their advantages such as targeted drug delivery and personalized medicine make them a fascinating area of research. The purpose of this review is to provide a comprehensive analysis and evaluation of existing research, highlighting the advancements, current challenges, advantages, limitations, and future prospects of bioinspired and biomimetic photocatalysts in biomedicine. © 2024 Chongqing UniversityÖğe Ionic liquid-based materials for electrochemical biosensing(Blackwell Publishing, 2022) Khorsandi, D.; Zarepour, A.; Rezazadeh, I.; Ghomi, M.; Ghanbari, R.; Zarrabi, A.; Esfahani F.T.Due to their interesting features including negligible volatility, ease of designing in the construction, good chemical, and thermal stability, and excellent ionic conductivity, ionic liquids (ILs) have attracted a lot of attention to themselves in recent years. They are constructed from asymmetric anions and cations and are found in a liquid state lower than 100°C. Their unique features introduce them as candidates for the application in the structure of different types of electrochemical biosensors, in which they could act as electrolytes, or could be used as detecting agents. According to these features, this review aims to present an overview of the application of ILs in the structure of electrochemical sensors and biosensors. Based on this, after a brief description of the ILs and biosensors, the application of ILs in the structure of some of the recent electrochemical biosensors has been discussed and then, remarks and perspectives on these types of biosensors are explained. © 2022 The Authors. Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.Öğe Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications(MDPI, 2022) Presutti, D.; Agarwal, T.b; Zarepour, A.; Celikkin, N.; Hooshmand, S.; Zarrabi, AliNanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated exceptional potential in the healthcare and diagnostic sectors. TMDCs have different enzymatic properties due to their unique nano-architecture, high surface area, and semiconducting properties with tunable band gaps. Furthermore, the compatibility of TMDCs with various chemical or physical modification strategies provide a simple and scalable way to engineer and control their enzymatic activity. Here, we discuss recent advances made with TMDC-based nanozymes for biosensing and therapeutic applications. We also discuss their synthesis strategies, various enzymatic properties, current challenges, and the outlook for future developments in this field. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
