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Öğe How reliable is the high-volume definition in prostate cancer patients: the potential game-changing role of PSMA(Lippincott Williams & Wilkins, 2023) Guven, Osman; Karyagar, Savas; Arici, Serdar; Ozulker, Tamer; Can, OrcunPurposeTo evaluate whether metabolic and volumetric data from Ga-68-PSMA PET/CT performed during staging of de-novo high-volume mCSPC patients who received docetaxel could be used to predict survival. MethodsForty-two de-novo high-volume mCSPC patients, who received ADT + Docetaxel and underwent Ga-68-PSMA PET/CT for staging, were included in the study. The association between patients' pathological data, all PSA measurements, treatments they received, the data obtained from Ga-68-PSMA PET/CT and progression-free and overall survival were examined. ResultsIn the multivariate analysis, PSMA-TV (primary) and PSMA-TV (WB) variables were shown to be independent negative predictors of overall survival. For the threshold value of 19.91 cm(3) obtained for PSMA-TV (primary), HR was calculated as 6.31, the 95% confidence interval (CI): 1.01-39.18, P = 0.048. For the threshold value of 1226.5 cm(3) obtained for PSMA-TV (WB) variable, HR was calculated as 58.62, the 95% CI: 2.55-1344.43, P = 0.011. In our study, SUVmax (WB) variable was found to be an independent and negative predictor of progression-free survival. For the determined threshold value of 17.74, HR was calculated as 16.24, 95% CI: 1.18-22.76, P = 0.037. ConclusionMetabolic and volumetric data obtained from Ga-68-PSMA PET/CT can be used to predict survival in de-novo high-volume mCSPC. Our results show that in ADT + Docetaxel receiving patients, a subgroup with higher PSMA-TV (WB) values have a significantly worse prognosis. This situation suggests that the high-volume disease definition in the literature may be insufficient for this group, and that Ga-68-PSMA PET/CT can play an essential role in demonstrating the heterogeneity within the group.Öğe INFECTIVITY AND REPLICATION INHIBITION EFFECT OF 5-FLUOROURACIL ON HERPES SIMPLEX VIRUS TYPE-1 ASSOCIATED WITH MUTATIONS IN THYMIDINE KINASE GENE(Soc Stiinte Farmaceutice Romania, 2022) Taskin, Mehmet Hakan; Kurucay, Hanne Nur; Kadi, Hamza; Tamer, Cuneyt; Ozan, Emre; Muftuoglu, Bahadir; Albayrak, HarunTwo pandemics over the first two decades of the 21st century have shown that viruses with epidemic and pandemic potentials constitute a major threat to human health due to the lack of effective antivirals. Developing new antivirals and treatment strategies is also as important as vaccines play a crucial role in the first line of preventing viral infections. Using base analogues that directly target viruses and understanding their action mechanisms can present essential alternative treatment strategies to combat viral diseases. The current study investigated the effects of a base analogue on herpes simplex virus type1 (HSV-1) replication in a cell culture system using the pyrimidine analogue 5-fluorouracil (FU). After that, the full-length UL-23 gene encoding thymidine kinase (TK) of HSV-1 was sequenced to detect induced mutations. The results showed a diminishing viral titre and viral load at 2 logs and 663 times, respectively, at the end of 10 consecutive passages with 5-FU. Furthermore, two mutations substitute amino acids in the non-conserved region of the TK gene, which confers drug resistance, were also identified. The current research is a feasibility study to investigate the antiviral effects of 5-FU on DNA viruses and has reinforced the fact that 5-FU can have an antiviral effect on HSV-1. However, drug resistance for viruses should not be underestimated.Öğe Effect of embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii(Springer, 2023) Ahmed, Usman; Ong, Seng-Kai; Khan, Khalid Mohammed; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed; Shaikh, Mohd Farooq; Alawfi, Bader SaleemAcanthamoeba castellanii is the causative agent of fatal encephalitis and blinding keratitis. Current therapies remain a challenge, hence there is a need to search for new therapeutics. Here, we tested embelin (EMB) and silver nanoparticles doped with embelin (EMB-AgNPs) against A. castellanii. Using amoebicidal assays, the results revealed that both compounds inhibited the viability of Acanthamoeba, having an IC50 of 27.16 +/- 0.63 and 13.63 +/- 1.08 mu M, respectively, while causing minimal cytotoxicity against HaCaT cells in vitro. The findings suggest that both samples induced apoptosis through the mitochondria-mediated pathway. Differentially expressed genes analysis showed that 652 genes were uniquely expressed in treated versus untreated cells, out of which 191 were significantly regulated in the negative control vs. conjugate. Combining the analysis, seven genes (ARIH1, RAP1, H3, SDR16C5, GST, SRX1, and PFN) were highlighted as the most significant (Log2 (FC) value +/- 4) for the molecular mode of action in vitro. The KEGG analysis linked most of the genes to apoptosis, the oxidative stress signaling pathway, cytochrome P450, Rap1, and the oxytocin signaling pathways. In summary, this study provides a thorough framework for developing therapeutic agents against microbial infections using EMB and EMB-AgNPs.Öğe Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies(Academic Press Inc Elsevier Science, 2024) Demir-Yazici, Kubra; Trawally, Muhammed; Bua, Silvia; Ozturk-Civelek, Dilek; Akdemir, Atilla; Supuran, Claudiu T.; Guzel-Akdemir, OzlenIn the pursuit of discovering new selective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, a small collection of novel thiosemicarbazides (5a-5t) were designed and synthesized starting from 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide which was evaluated as a potent inhibitor of different CA isoforms in a previous study. The newly synthesized compounds were examined against four human carbonic anhydrases (hCA), namely transmembrane tumor-related hCA IX/XII and cytosolic widespread off-targets hCA I/II. In enzyme inhibition assays, all nineteen compounds display up to similar to 340-fold selectivity for hCA IX/XII over off-target isoforms hCA I/II. Four compounds have enzyme inhibition values (K-i) lower than 10 nM against tumor-associated isoforms hCA IX/XII including two compounds in the subnanomolar range (5r and 5s; hCA XII; K-i: 0.69 and 0.87 nM). The potential binding interactions of the most potent compounds against hCA IX and XII, compounds 5s and 5r, respectively, were investigated using ensemble docking and molecular dynamics studies. Cell viability assays using human colorectal adenocarcinoma cell line HT-29 and healthy skin fibroblasts CCD-86Sk show that compound 5e selectively inhibits HT-29 cancer cell proliferation (IC50: 53.32 +/- 7.74 mu M for HT-29; IC50: 74.64 +/- 14.15 mu M for CCD-986Sk). Finally, Western blot assays show that compounds 5e and 5r significantly reduce the expression of hCA XII in HT-29 cells. Moreover, 5e shows better cytotoxic activity in hypoxia compared to normoxic conditions. Altogether, the newly designed compounds show stronger inhibition of the tumor-associated hCA IX and XII isoforms and several tested compounds show selective cytotoxicity as well as downregulation of hCA XII expression.Öğe Effect of computer-aided design and computer-aided manufacturing technique on the accuracy of fixed partial denture patterns used for casting or pressing(Elsevier Sci Ltd, 2023) Donmez, Mustafa Borga; Yilmaz, Burak; Yoon, Hyung-In; Kahveci, Cigdem; Schimmel, Martin; Cakmak, GulceObjectives: To evaluate the effect of additive and subtractive manufacturing on the accuracy (trueness and pre-cision) of fixed partial denture patterns (FPDPs) used for casting or pressing.Materials and Methods: A 3-unit complete coverage FPD on mandibular right first premolar and first molar teeth was virtually designed. Using the design data, FPD patterns were fabricated from an additively manufactured resin (PR, ProArt Print Wax) and 2 CAD-CAM wax discs (YW, ProArt CAD Wax Yellow and BW, ProArt CAD Wax Blue) (n = 10). Each pattern was then digitized with a scanner (CEREC Primescan) and evaluated for 3D surface deviation at 4 different surfaces (overall, external, marginal, and intaglio surfaces) by using a 3D analysis software (Medit Link). Root mean square (RMS) values were automatically calculated. Data were analyzed by using Kruskal-Wallis and Dunn's post hoc tests for trueness and precision (alpha= 0.05).Results: Significant differences were found among the RMS values for overall (P<.001) and each surface (P <=.040) evaluated. PR had the highest overall (P <=.011) and intaglio surface (P <=.01) deviations, while the difference between YW and BW was not significant (P >=.199). PR had the highest (P <=.027) and BW had the lowest (P <=.042) external surface mean RMS values. BW had higher mean marginal RMS value than YW (P=.047). For precision, significant differences were observed among test groups only for marginal RMS values (P=.002). PR had lower precision than BW (P=.002).Conclusions: BW and YW FPDPs mostly had higher trueness compared with PR FPDPs. However, considering relatively smaller deviations at marginal and intaglio surfaces and the fact that patterns mostly had similar precision, clinical fit of FPDs fabricated by using tested patterns may be similar.Clinical Significance: Definitive 3-unit fixed partial dentures fabricated by using tested patterns may be similar. However, FPDs fabricated with tested additively manufactured resin patterns might result in more chairside adjustments than those fabricated with tested subtractively manufactured wax patterns.Öğe Surface characteristics and wettability of novel gingival col designed 3-D printed dental sectional matrices(Walter De Gruyter Gmbh, 2024) Celik, Zeynep Ceren; Elbek Cubukcu, Cigdem; Celik, HalilObjective: The physical properties and wettability of 3-D printed Polyethylene terephthalate - glycol (PET-G) and Poly(lactic) acid (PLA) dental sectional matrices were investigated. Methods: Experimental matrices was designed in a rectangular shape one-side depression corresponds to gingival col and without sharp edges and printed on FDM machine Ender Pro 3 (Creality((R)), Shenzhen, China). The physical textures, thicknesses, water contact angles were compared to conventional stainless steel (SS) matrix. Results: PETG and PLA sample matrices were clinically single-side smooth compared to SS matrix. PETG specimens had uniformly 0.055 mm whereas PLAs were non-uniformly similar to 0.065-0.075 mm in thickness. The mean +/- standard deviation (SS) of contact angle for SS was 78.29 +/- 0.18, for PETG was 72.09 +/- 0.94, for PLA was 73.03 +/- 1.17. Conclusion: PETG and PLA dental matrices might have desirable properties: being hydrophobic, non-charged, easy to manufacture and mimicking the gingival col depression in the dental interproximal contact area.Öğe Bending, buckling and free vibration behaviours of 2D functionally graded curved beams(Elsevier Science Inc, 2023) Karamanli, Armagan; Wattanasakulpong, Nuttawit; Lezgy-Nazargah, M.; Vo, Thuc P.The flexural, free vibration and buckling responses of 2D-FG curved beams with various shear deformation theories are presented by using finite element model. Their material properties via both directions (length and thickness) are varied with power-law distribution. A two-node beam element satisfying C1 continuity requirement is employed to solve the problems. Various problems including isotropic, 1D- and 2D-FG curved beams are analysed and the obtained results are verified with those available in the literature. Comprehensive parameter examinations are carried out to depict the effects of gradation indexes in both directions, open angles, end conditions and aspect ratios on structural behaviours of 2D-FG curved beams.Öğe Task Scheduling in Cloud Computing: A Priority-Based Heuristic Approach(Ieee-Inst Electrical Electronics Engineers Inc, 2023) Lipsa, Swati; Dash, Ranjan Kumar; Ivkovic, Nikola; Cengiz, KorhanIn this paper, a task scheduling problem for a cloud computing environment is formulated by using the M/M/n queuing model. A priority assignment algorithm is designed to employ a new data structure named the waiting time matrix to assign priority to individual tasks upon arrival. In addition to this, the waiting queue implements a unique concept based on the principle of the Fibonacci heap for extracting the task with the highest priority. This work introduces a parallel algorithm for task scheduling in which the priority assignment to task and building of heap is executed in parallel with respect to the non-preemptive and preemptive nature of tasks. The proposed work is illustrated in a step-by-step manner with an appropriate number of tasks. The performance of the proposed model is compared in terms of overall waiting time and CPU time against some existing techniques like BATS, IDEA, and BATS+BAR to determine the efficacy of our proposed algorithms. Additionally, three distinct scenarios have been considered to demonstrate the competency of the task scheduling method in handling tasks with different priorities. Furthermore, the task scheduling algorithm is also applied in a dynamic cloud computing environment.Öğe Verifying the seating of a 3D-printed removable die using elastomeric matrices: A dental technique(Wiley, 2024) Azpiazu-Flores, Francisco X.; Donmez, Mustafa Borga; Lin, Wei-Shao; Morton, Dean; Yilmaz, BurakComputer-aided design and computer-aided manufacturing systems enable digital designing and 3-dimensional (3D) printing of definitive casts with removable dies. However, the fit of the removable dies should be without interferences for their accurate positioning in the cast. Given that the accuracy of additive manufacturing depends on design- and manufacturing-related factors, verifying the accuracy of the position of 3D-printed removable dies in their cast is essential to fabricate positionally accurate definitive prostheses, which would enable minimal or no laboratory and clinical adjustments. This dental technique article presents a straightforward approach to verify the seating of a 3D-printed removable die by using verification matrices made of a polyvinylsiloxane interocclusal registration material.Öğe Dosimetric evaluation of PLA and ABS materials produced by two different production techniques(Springernature, 2024) Karacam, Songuel Cavdar; Tuncman, Duygu; Sahin, Tulin; Sahin, Senol; Ergen, Sefika Arzu; Dagdelen, Meltem; Uzel, Omer ErolIn radiotherapy applications, with the aim of accurately delivering the prescribed dose in-patient treatments, a wide variety of organic and/or inorganic materials can be utilized as bolus material. In recent years, polymer materials have become a wide range of scientific research in radiotherapy. Especially, PLA (polylactic acid) and acrylonitrile butadiene styrene (ABS) materials are widely utilized in various applications within the field of radiotherapy. While three-dimensional (3D) printing, especially using fused deposition modeling (FDM) technology, was among the first techniques adopted, plastic injection molding (IM) has also been a well-established manufacturing method for many years. Initially, ABS and PLA materials were 3D-printed on an FDM 3D printer as square prisms measuring 12 x 12 x 1 cm3. These were specifically designed for use as measurement instruments in radiation assessments. Subsequently, identical test materials were produced through IM in an ISO D2-type mold made of S235JR steel (material number 1.0038) with the same dimensions. In radiotherapy applications, it is important for clinical use to evaluate the material of dosimetric properties as well as tissue equivalence. The goal was to dosimetrically evaluate the response of these materials to radiation produced by both FDM and IM techniques. Hounsfield units (HU) values were determined with the CT simulator device for all materials. Dosimetric measurements were performed using a 6-MV nominal photon energy. Percentage depth doses, dose profiles, and radio transmittance measurements of the materials were conducted in a water phantom and solid water phantom. All measurements were also conducted for commercially available bolus materials used in patients. Commercial bolus was used as a reference due to its routine use in the clinic. Although the dosimetric parameters for materials produced through 3D printing and plastic injection molding yielded similar results among themselves and with bolus material, it is advisable to evaluate the material dosimetrically before its use as a personal material on a patient due to printing characteristics and material variability.Öğe a-Whittaker controllability of ?-Hilfer fractional stochastic evolution equations driven by fractional Brownian motion(Springer Heidelberg, 2023) Ghaemi, Mohammad Bagher; Mottaghi, Fatemeh; Saadati, Reza; Allahviranloo, TofighIn this paper, we study the fractional-order system in the sense of?-Hilfer fractional stochastic evolution equations driven by fractional Brownian motion. Applying the fixed point tech-nique, we prove that there exists a mild solution for the problem and introduce a new type of stability. Finally, we present two examples to demonstrate how the obtained results might be applied.Öğe Application of fuzzy ABC fractional differential equations in infectious diseases(Univ Tabriz, 2024) Babakordi, Fatemeh; Allahviranloo, TofighIn this paper, for solving the HIV fuzzy mathematical model, it is first transformed into a system of three nonlinear fuzzy Atangana-Baleanu-Caputo (ABC) fractional differential equations with three unknowns and fuzzy initial values. Then, using the generalized Hukuhara difference and ABC fractional derivative and applying the fuzzy numerical ABC-PI method, its fuzzy solution is calculated. Moreover, some theorems are defined to prove the existence and uniqueness of the solution. Then, it is explained that the proposed method can be used for the system of any equations with unknowns.Therefore, in order to determine the solution of the fuzzy mathematical model of the transmission of COVID-19, it is transformed into a system of six nonlinear fuzzy Atangana-Baleanu-Caputo (ABC) fractional differential equations with six unknowns and fuzzy initial values and is solved similarly. At the end, a numerical example is presented to verify the effectiveness of the proposed method.Öğe Efficacy/safety of entrectinib in patients (pts) with ROS1-positive (ROS1 +) advanced/metastatic NSCLC from the Blood First Assay Screening Trial (BFAST)(Lippincott Williams & Wilkins, 2022) Peters, Solange; Gadgeel, Shirish M.; Mok, Tony S. K.; Nadal, Ernest; Kilickap, Saadettin; Perol, Maurice; Cadranel, Jacques[Abstract Not Available]Öğe EARTHQUAKE DISASTER AND ITS' ACUTE EFFECT ON PEDIATRIC HEMATOLOGY AND ONCOLOGY.IN TURKIYE; TURKISH PEDIATRIC ONCOLOGY GROUP-TPOG QUESTIONARE STUDY(Wiley, 2023) Tacyildiz, Nurdan; Ozdemir, Sonay Incesoy; Kupeli, Begul; Cemaloglu, Mustafa; Acipayam, Can; Oncel, Kahraman; Akinel, Ayse Nur[Abstract Not Available]Öğe EXPERIENCES OF PARENTS WHO CONCEIVED SAVIOR SIBLINGS FOR BEING HEMATOPOIETIC STEM CELL DONORS TO THEIR SICK CHILDREN AND SUCCESSFULLY COMPLETED THE PROCESS: A QUALITATIVE STUDY(Springernature, 2023) Eker, Ibrahim; Ozdemir, Hamide Nur Cevik; Yilmaz, Firat; Yesilipek, Akif; Kupesiz, Alphan; Uygun, Vedat; Karasu, Gulsun[Abstract Not Available]Öğe Circulating tumor DNA (ctDNA) dynamics and survival outcomes in patients (pts) with advanced non-small cell lung cancer (aNSCLC) and high (>50%) programmed cell death-ligand 1 (PD-L1) expression, randomized to cemiplimab (cemi) vs chemotherapy (chemo)(Lippincott Williams & Wilkins, 2023) Vokes, Natalie I.; Gandara, David R.; Sezer, Ahmet; Kilickap, Saadettin; Gumus, Mahmut; Bondarenko, Igor; Ozguroglu, Mustafa[Abstract Not Available]Öğe First-line cemiplimab for locally advanced non-small cell lung cancer: Updated subgroup analyses from EMPOWER-Lung 1 and EMPOWER-Lung 3(Elsevier Science Inc, 2023) Kalinka, E.; Bondarenko, I.; Gogishvili, M.; Melkadze, T.; Baramidze, A.; Sezer, A.; Makharadze, T.[Abstract Not Available]Öğe Three-year Outcomes per PD-L1 Status and Continued Cemiplimab Beyond Progression plus Chemotherapy: EMPOWER-Lung 1(Elsevier Science Inc, 2023) Garassino, M. C.; Kilickap, S.; Ozguroglu, M.; Sezer, A.; Gumus, M.; Bondarenko, I.; Gogishvili, M.[Abstract Not Available]Öğe EMPOWER-Lung 1: Cemiplimab (CEMI) monotherapy as first-line (1L) treatment of patients ( pts) with brain metastases from advanced non-small cell lung cancer (aNSCLC) with programmed cell death-ligand 1 (PD-L1) ?50%-3-year update(Elsevier Science Inc, 2023) Kilickap, S.; Ozguroglu, M.; Sezer, A.; Gumus, M.; Bondarenko, I.; Gogishvili, M.; Turk, H. M.[Abstract Not Available]Öğe COVID-19: Acanthamoeba Creeps into the Brain(Iranian Scientific Society Medical Entomology, 2023) Siddiqui, Ruqaiyyah; Niyyati, Maryam; Abouleish, Mohamed Yehia; Khamis, Mustafa; Ibrahim, Taleb; Khan, Naveed Ahmed[Abstract Not Available]
