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Öğe Laparoscopic Versus Conventional Open Congenital Duodenal Obstruction Repair: A Systematic Review and Meta-analysis(W.B. Saunders, 2025) Azizoğlu, Mustafa; Kamçı, Tahsin Onat; Klyuev, Sergey; Escolino, Maria; Karakaş, Esra; Gigena, Cecilia; Yüksel, Seçil; Bakır, Ayten Ceren; Okur, Mehmet Hanifi; Shehata, SamehBackground: We conducted a systematic review and meta-analysis to evaluate the safety and effectiveness of laparoscopic surgery (LS) compared to open surgery (OS) for congenital duodenal obstruction (CDO). Methods: We conducted a literature review to find studies comparing LS and OS in neonates with CDO. A meta-analysis was conducted to systematically compile and compare factors, including surgical duration, time of feeding initiation, hospital length of stay (LOS), and postoperative complications. Results: Eleven studies with 1615 patients (LS: 338, OS: 1277) met inclusion criteria. Operative time was observed to be much shorter in the OS group (I2 = 97%); weighted mean difference (WMD) 60.29; 95% confidence interval (CI): 30.29 to 90.28; p < 0.0001). The LS group had a significantly shorter time to initiate feeding (I2 = 0%; WMD -3.38, 95% CI: −4.35 to −2.41; p < 0.00001), shorter time to full feeding (I2 = 0%; WMD -3.64, 95% CI: −5.06 to −2.22; p < 0.00001), and shorter LOS (I2 = 52%; WMD -3.42, 95% CI: −5.75 to −1.08; p = 0.004). There were no significantly differences in the rates of anastomotic leak (I2 = 24%; OR 0.76, 95% CI: 0.12 to 4.67; p = 0.76), anastomotic stricture (I2 = 0%; OR 1.12, 95% CI: 0.39 to 3.20; p = 0.83), postoperative ileus (I2 = 0%; OR 0.60, 95% CI: 0.21 to 1.74; p = 0.34), and overall complications between the groups (I2 = 59%; OR 0.86, 95% CI: 0.42 to 1.74; p = 0.68). The LS group, however, had a significantly decreased frequency of wound infection (I2 = 0%; OR 0.26, 95% CI: 0.08 to 0.82; p = 0.02). Conclusion: Despite certain limitations in our analysis, the laparoscopic approach was associated with comparable postoperative outcomes. Levels of Evidence: 2a. Type of the Study: Meta analysis. © 2024 Elsevier Inc.Öğe Letter to the Editor in Response to: The Intraperitoneal Use of Cephazolin: A Novelty in the Prevention of Intra-abdominal Abscess After Laparoscopic Appendectomy in Children(W.B. Saunders, 2025) Karakaş, Esra; Akbaş, Zekeriya Tayyib; Azizoğlu, MustafaÖğe Letter to the Editor in Response to: Short- and Long-Term Outcomes of Thoracoscopic and Open Repair for Esophageal Atresia and Tracheoesophageal Fistula(W.B. Saunders, 2025) Azizoğlu, Mustafa; Klyuev, Sergey; Yüksel, Seçil; Erdem Şit, Tuba; Karakaş, EsraLetter to the Editor in Response to: Short- and Long-Term Outcomes of Thoracoscopic and Open Repair for Esophageal Atresia and Tracheoesophageal FistulaÖğe Melt-processable and electrospinnable shape-memory hydrogels(Wiley, 2024) Abdullah, Turdimuhammad; Altınkök, Çağatay; Okay, OğuzDue to their ability to adapt to subtle changes in response to various external and internal stimuli, smart hydrogels have become increasingly popular in research and industry. However, many currently available hydrogels suffer from poor processability and inferior mechanical properties. For example, the preparation of a hydrogel network that can be subjected to melt processing and electrospinning is challenging. Herein, a series of mechanically strong, shape-memory hydrogels based on polyacrylic acid (PAAc) chains containing 20-50 mol% of crystallizable n-octadecylacrylate (C18A) segments are prepared by an organosolv method followed by in situ physical cross-linking via hydrophobic interactions. The hydrogels exhibit a reversible strong to weak gel transition at 50-60 degrees C and can be melt-processed at 60-100 degrees C, depending on the molar fraction of C18A. Additionally, the hydrogels can be dissolved in chloroform/ethanol mixture to form a viscous solution, which can then be used to produce a nanofibrous network by electrospinning. Effects of polymer concentration, volume ratio of solvents, and mole fraction of C18A on electrospinning are investigated to produce smooth, uniform nanofibers with small fiber diameter. The produced nanofibers, while maintaining their chemical structure, show significantly improved water adsorption capacity, enhanced mechanical properties, and fast shape-memory performance.Öğe Comparing Loop and Divided Colostomy for Anorectal Malformation: A Systematic Review and Meta-Analysis(W.B. Saunders, 2025) Gerçel, Gonca; Azizoğlu, Mustafa; Karakaş, Esra; Risteski, ToniIntroduction: The optimal type of colostomy for patients with anorectal malformations (ARM) remains unclear. We conducted a systematic review and meta-analysis to compare the clinical outcomes of loop colostomies (LC) versus divided colostomies (DC) in patients with ARM. Methods: After review registration (PROSPERO: CRD42024513335), we searched multiple databases for comparative studies on LCs and DCs in patients with ARMs. Gray literature was sought. The complications examined included stoma prolapse, urinary tract infection (UTI), skin excoriation, stoma retraction, parastomal hernia, wound infection rate, and stoma stricture. Three reviewers independently assessed the eligibility and quality of the included studies. Meta-analysis of selected complications was performed using Revman 5.4, with p < 0.05 considered significant. Results: Eleven studies were included in the analysis, incorporating a total of 2550 neonates with ARMs, of which 1147 underwent LCs and 1403 underwent DCs. The meta-analysis revealed no significant differences between the two groups in the incidence of stoma prolapse (OR: 1.55, 95 % CI: 0.63 to 3.79; p = 0.34), UTIs (OR: 1.78, 95 % CI: 0.50 to 6.36; p = 0.38), skin excoriation (OR: 1.26, 95 % CI: 0.68 to 2.34; p = 0.46), stoma retraction (OR: 0.79, 95 % CI: 0.09 to 6.64; p = 0.83), parastomal hernia (OR: 0.99, 95 % CI: 0.22 to 4.48; p = 0.99), wound infection (OR: 0.35, 95 % CI: 0.10 to 1.20; p = 0.10), and stoma stricture (OR: 0.70, 95 % CI: 0.22 to 2.18; p = 0.53). Conclusions: The findings suggest that LCs and DCs are viable options for fecal diversion, presenting similar risks and benefits. The choice between these techniques should consider individual patient characteristics and surgical expertise. Type of Study: Meta-analysis. Level of evidence: II. © 2024 Elsevier Inc.Öğe Indocyanine Green (ICG) Assisted Laparoscopic Palomo Varicocelectomy(W.B. Saunders, 2025) Azizoğlu, Mustafa; Yüksel, Seçil; Kayrancıoğlu, Beril; Karakaş, Esra; Karaaslan, Birgül; Saraç, FatmaIndocyanine Green (ICG) Assisted Laparoscopic Palomo VaricocelectomyÖğe Platelet-rich Plasma as an Adjuvant Therapy to Crystallized Phenol in the Treatment of Pediatric Pilonidal Sinus Disease: A Prospective Randomized Controlled Trial(W.B. Saunders, 2025) Azizoğlu, Mustafa; Klyuev, Sergey; Kamçı, Tahsin Onat; Okur, Mehmet HanifiObjective: This study aims to evaluate the safety and efficacy of platelet-rich plasma (PRP) as an adjuvant to crystallized phenol (CP) in treating pediatric pilonidal sinus disease (PSD). Methods: A single-center randomized controlled trial was conducted at Istanbul Esenyurt Hospital. Eighty-seven patients aged 0–18 were randomly assigned to two groups: the CP group (n = 42) and the CP + PRP group (n = 45). Upon arrival at the clinic, patients began a regimen of manual shaving and, if necessary, laser epilation every 6–8 weeks. For those with pilonidal abscesses, incision, drainage, and antibiotics were given. The treatment area was sterilized and numbed with local anesthesia. Hair removal and curettage were performed, followed by the application of crystallized phenol. In CP + PRP group, PRP injections were also administered. The procedure concluded with wound dressing and thorough disinfection. The study was registered https://clinicaltrials.gov/ (NCT06324656). Results: The CP + PRP group demonstrated significantly shorter healing times (19.4 ± 7.88 days) compared to the CP group (30.7 ± 12.9 days) (p < 0.001). The cosmetic score was higher in the CP + PRP group (7.42 ± 1.61) than in the CP group (6.11 ± 1.88, p = 0.001). CP + PRP group had lower VAS scores at measured all-time points after applications (p < 0.05 for each). Complications were comparable between the groups, with no significant differences in bleeding, infections, or skin burns (p > 0.05 for each comparison). No difference was found between groups in terms of total complication rate (p = 0.398). The success rate was higher in CP + PRP group (98%; n = 44) compared to CP group (86%; n = 36) (p = 0.039). Recurrence rates were lower in CP + PRP group (2%; n = 1) than CP group (14%; n = 6) (p = 0.039). Conclusion: The autologous PRP injection in pediatric PSD is safe. The addition of PRP to CP treatment for pediatric PSD significantly improves healing time, cosmetic outcomes, and overall success rates without increasing complication rates. This combined approach offers a promising alternative for effective and efficient treatment of PSD in children. Type of the study: Randomized controlled trial. Level of evidence: Level I © 2024 Elsevier Inc.Öğe Antibacterial, antioxidant, and healing potential of wound dressings utilizing cranberry extract in combination with methacrylated polyvinyl alcohol and methacrylated sericin(Springer, 2024) Özkahraman, Bengi; Torkay, Gülşah; İdil, Neslihan; Özbaş, Zehra; Bal Öztürk, AyçaPurposeHydrogels, due to their hydrophilic nature and tunable properties, have emerged as promising materials for wound dressings. Notably, the ability to incorporate antibacterial and antioxidant agents into hydrogels offers significant advantages in reducing bacterial colonization, scavenging reactive oxygen species (ROS), mitigating inflammation, and accelerating wound closure. This study investigated the potential of cranberry extract (CR)-incorporated poly(vinyl alcohol)/silk sericin (PVAMA/SERMA) hydrogel wound dressings to promote effective antimicrobial activity and wound healing.MethodsMethacrylated poly(vinyl alcohol) (PVAMA) and silk sericin (SERMA) pre-polymers were synthesized. The wound dressings consisting of PVAMA, SERMA, and CR were fabricated by photopolymerization method. The chemical and thermal structures of wound dressings were investigated by FTIR and TGA analysis. The assessment of the physical characteristics was conducted through the analysis of swelling and in vitro degradation tests. The effect of various concentrations of CR in wound dressings on cytotoxicity and healing performance of NIH/3T3 fibroblast cell line was examined using extract-based MTT and scratch assays, respectively. Antibacterial and antioxidant properties of the wound dressing were performed against Escherichia coli and Staphylococcus aureus aureus using the agar diffusion method and DPPH assay, respectively.ResultsThe findings suggest that CR-loaded PVAMA/SERMA hydrogels hold promise as novel wound dressing materials due to their enhanced antibacterial, antioxidant, and wound healing capabilities, potentially accelerating wound recovery.Lay SummaryHydrogels, due to their hydrophilic nature, tunable chemical, mechanical, and biological properties, have shown great promises for wound dressing application. Notably, antibacterial and antioxidant hydrogels reduce bacterial colonization and infection, scavenge ROS, relieve inflammation, and accelerate wound healing. In this study, The PVAMA/SERMA-based wound dressings with various concentrations of CR (0, 1, and 2 wt % of polymer) were prepared by the photopolymerization method to achieve effective antimicrobial and wound healing potential.Öğe Shehata technique versus fowler-stephens orchidopexy in intra-abdominal testis: a meta-analysis(Elsevier ltd, 2024) Azizoğlu, Mustafa; Zain, Mostafa; Karakaş, Esra; Kotb, Mostafa; Kamçı, Tahsin Onat; Bakır, Ayten Ceren; Shehata, SamehIntroduction The management of intra-abdominal testis (IAT) represents a significant clinical challenge, necessitating the transposition of the testis from the abdominal cavity to the scrotum. This procedure is rendered complex by the abbreviated length of the testicular vessels. Objective Our purpose in this study was to conduct a systematic review and meta-analysis comparing Shehata technique (ST) versus Fowler Stephens technique (FST) in treating patients with IAT. Study design We conducted a comprehensive literature search using several databases, including Ovid Medline, Cochrane, PubMed, Google Scholar, Web of Sciences, EMBASE, and SCOPUS until February 2024. This study included research that compared ST and FST for managing intra-abdominal testis. We evaluated the rates of atrophy and retraction, as well as the overall success rates, for both techniques. Results Six studies were identified as appropriate for meta- analysis, comparing orchidopexy performed using the ST with 169 patients, against the FST involving 162 patients. The comparison showed no statistically significant age difference at the time of surgery between the groups (I2 2 = 0%) (WMD 0.05, 95% CI- 1.24 to 1.34; p = 0.94). Operative time in first the stage was lower in the FST group than ST group (I2 2 = 95%) (WMD 10.90, 95% CI 1.94 to 19.87; p = 0.02). Operative time in the second stage was lower in the ST group than FST group (I2 2 = 83%) (WMD-6.15, 95% CI- 12.21 to-0.10; p = 0.05). Our analysis showed that ST had a similar atrophy rate (I2 2 = 0%) (OR: 0.45, 95% CI: 0.20 to 1.01; p = 0.05). No difference was found between techniques in terms of retraction rate (I2 2 = 0%) (OR: 0.64, 95% CI: 0.17 to 2.47; p = 0.52). The ST demonstrated a notably higher overall success rate compared to FST (I2 2 = 1%) (RR: 1.14, 95% CI: 1.03 to 1.27; p = 0.009). Overall success rate in ST and FST were 87% and 74%, respectively. Overall atrophy rate in ST and FST were 5% and 12%, respectively. Overall retraction rate in ST and FST were 5% and 10%, respectively. Discussion The ST, renowned for its pioneering two-stage laparoscopic approach that leverages mechanical traction to lengthen the testicular vessels, is gaining popularity due to its recognized safety and efficacy. Conversely, the Fowler-Stephens technique, a traditional method that relies on collateral blood supply for testicular mobilization, has come under examination for its potential link to an increased risk of testicular atrophy. Conclusion This meta-analysis reveals that the Shehata technique has similar or better outcomes compared to the Fowler-Stephens technique in IAT management. Further prospective multicentric randomized controlled trials are warranted.Öğe Enhancing Data Transparency in Pediatric Surgery: The Potential of Sankey Diagrams for Complex Data Visualization(W.B. Saunders, 2025) Azizoğlu, MustafaEnhancing Data Transparency in Pediatric Surgery: The Potential of Sankey Diagrams for Complex Data VisualizationÖğe Alisklamp versus Conventional Dorsal Slit Circumcision: A Multicentric Randomized Controlled Trial(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Azizoğlu, Mustafa; Risteski, Toni; Klyuev, SergeyBackground: There are numerous methods of circumcision performed worldwide, typically classified into two main groups: conventional surgical techniques and various device-assisted techniques. Each method has its own advantages, limitations, and potential complications. The aim of this study was to compare outcomes of the Alisklamp technique versus the dorsal slit technique in male circumcision procedures. Method: This multicenter RCT compared the dorsal slit and Alisklamp techniques for circumcision, assessing patient demographics and intraoperative and postoperative outcomes. All patients, under local anesthesia via dorsal penile nerve block, were discharged on the same day and followed up at 24–48 h, 1 week, and 1 month. Results: A total of 180 patients enrolled, and 166 patients were included. The study compared postoperative outcomes between the Alisklamp (AK) and dorsal slit (DS) circumcision techniques in 166 patients. Key findings included significantly higher penile edema in the DS group (19%) compared to the AK group (2.4%) (p < 0.001), with severe edema occurring only in the DS group. Wound gaping was more common in the AK group (8.3%) compared to the DS group (1.2%) (p = 0.030). Skin tunnels were observed only in the DS group (9.5%) (p = 0.004). There were no significant differences in nausea, vomiting, bleeding, necrosis, infection, wound dehiscence, chordee, rotational anomalies, or secondary phimosis between the groups. Mean operation time was lower in the AK group than the DS group (7.8 min vs. 15.5 min; p < 0.001). Conclusions: The Alisklamp technique is recommended as the preferred method for circumcision because it minimizes complications, shortens the procedure time, and is easy to apply. © 2024 by the authors.Öğe Commentary on “Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants”(Springer Science and Business Media Deutschland GmbH, 2024) Azizoğlu, Mustafa; Klyuev, Sergey; Çakmak, MehmetCommentary on “Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants.Öğe Innovative biosensor technologies in the diagnosis of urinary tract infections: a comprehensive literature review(Springer, 2024) Çelik, Haluk; Caf, Balım Bengisu; Çebi, GizemUrinary tract infections (UTIs) are prevalent bacterial infections globally, posing significant challenges due to their frequency, recurrence, and antibiotic resistance. This review delves into the advancements in UTI diagnostics over the past decade, particularly focusing on the development of biosensor technologies. The emergence of biosensors, including microfluidic, optical, electrochemical, immunosensors, and nanotechnology-based sensors, offers enhanced diagnostic accuracy, reduced healthcare costs. Despite these advancements, challenges such as technical limitations, the need for cross-population validation, and economic barriers for widespread implementation persist. The integration of artificial intelligence and smart devices in UTI diagnostics, highlighting the innovative approaches and their implications for patient care. The article envisions a future where multidisciplinary research and innovation overcome current obstacles, fully leveraging the potential of biosensor technologies to transform biosensor-based UTIs diagnosis. The ultimate goal is to achieve rapid, accurate, and non-invasive diagnostics, making healthcare more accessible and effective.Öğe Artificial Intelligence in Cancer: A SWOT Analysis(İzmir Academy Association, 31 Aralık 2024) Torkay, Gülşah; Fadlallah, Nouran; Karagöz, Ahmet; Canlı, Mesut; Saydam, Ezgi; Mete, Ayşenur; Kızılışık, Furkan; Darici, Hakan; Yeşil, YusufCancer, a collection of maladies that has undergone extensive examination over centuries, remains a formidable challenge. Despite the array of available pharmacological and therapeutic interventions, the intricate molecular dynamics and heterogeneity of cancer continue to challenge the scientific community. Artificial Intelligence (AI) emerges as a promising avenue, offering the potential for expedited, precise diagnostics devoid of human expertise. Additionally, AI facilitates the tailoring of patient-specific therapeutic strategies targeting various facets of cancer, spanning macroscopic to microscopic levels. Nonetheless, it is imperative to scrutinize the potential benefits and limitations of AI technologies in this context. This review undertakes a comprehensive Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis of AI's application in cancer. An extensive compilation of AI applications encompasses predictive modeling, diagnostic capabilities, prognostic assessments, and personalized therapeutic modalities, spanning genomic analyses to individualized treatment regimens. The synthesis of evidence suggests that the advantages of AI outweigh its drawbacks; nevertheless, obstacles to its widespread integration persist.Öğe HCT116 ve HT29 Kolon Kanseri Hücrelerinde 5-Florourasil Kaynaklı Hücre Ölümünün Fourier Dönüşümlü Kızılötesi Spektroskopisi ile İncelenmesi(Düzce Üniversitesi, 31 Ocak 2023) Özerkan, Dilşad; Kalındemirtaş, Ferdane Danışman; Tüzemen, NaciKolon kanseri, tüm dünyada yaygın olan ve yüksek oranda ölümcül bir kanser tipidir. Tüm kanserlerde olduğu gibi kolon kanserinin seyrinin izlenmesi kritik bir öneme sahiptir. 5-Florourasil (5-FU) kolon kanserlerinde sıklıkla kullanılan bir antikanser ilaçtır ve hücre ölümü esnasında hücrelerde bir takım biyokimyasal ve moleküler farklılıklara neden olmaktadır. Bu çalışmada HCT116 ve HT29 kolon kanseri hücreleri 5-FU kemoterapi ilacı ile inkübe edildikten sonra, 5FU’nun hücreler üzerinde oluşturduğu biyokimyasal değişikliğin tespiti için Fourier transform kızılötesi (FTIR) spektroskopisi kullanılmıştır. 5-FU'nun inhibisyon yüzdesinin 50'ye eşit olduğu konsantrasyonu (IC50), MTT yöntemi kullanılarak belirlendi. IC50 değeri saptandıktan sonra FTIR ölçümleri alındı. Buna göre, 5-FU IC50 değeri sırasıyla HCT116 hücreleri için 12,69 µg/ml, HT29 hücreleri için 10,10 µg/ml bulunmuştur. 5-FU’nun sebep olduğu hücre ölümünün göstergeleri olduğu söylenen lipit içeriğindeki artış ile nükleik asit oranı, total hücresel proteinlerin α-sarmal ve β-yaprak ikincil yapıları ve aminoasit kalıntılarının azalması, kollajen konformasyonundaki değişiklikler gibi IR biyobelirteçlerindeki değişiklikler FTIR spektroskopisi ile gösterilmiştir. Sonuç olarak hem ucuz ve hem de hızlı bir yöntem olan FTIR ile kanser hücre ölümünün incelenmesi alternatif bir yöntem olarak kullanılabilir.Öğe Smartphone-Based Point-of-Care Urinalysis Vivoo App: A Validation Study(International Society of Academicians, 15 Nisan 2024) Caf, Balım Bengisu; Çebi, Gizem; Çelik, Haluk; Noroozi, Aliasghar; Atasever, Ali; Tayfun, MirayPoint-of-care (POC) analysis has emerged as a pivotal approach in providing rapid and convenient medical diagnostics. Smartphone-based solutions further augment the accessibility and ease of POC, enabling efficient on-the-go analysis. The integration of smartphone technology with POC has paved the way for innovative applications such as the Vivoo App, which empowers users to monitor various health parameters conveniently. Our study validated the accuracy and reliability of the smartphone-based POC urinalysis Vivoo mobile application. A comparative approach was followed wherein artificial urine samples were analyzed using both the Vivoo and traditional laboratory methods. A diverse range of health parameters were assessed. A total of 2618 strips were used over the course of this study to evalate the accuracy of Vivoo. The test strips results appeared to match exactly the expected measurement results. In addition, when the ±1 color block acceptance criterion was applied, 2608 of 2618 measurements of the tested strips were found to have met the expected measurement results completely. Based on the results, the 95% confidence interval for the exact match agreement proportion of Vivoo is 87.55% ± 1.27% and 99.62% ± 0.24%. As a wellness product, this study thus concludes that the Vivoo is appropriate in terms of both device reliability and performance. The app's ability to provide accurate and timely health results offers promising opportunities to improve individual health management.Öğe Evaluation of Traceability of Dietary Urine Biochemistry Changes with Commercial Urine Strips(Marmara University, 28 Haziran 2024) Çebi, Gizem; Caf, Balım Bengisu; Kozan, Esra; Derman, Serap; Çelik, Haluk; Tayfun, MirayObjective: This research aims to (i) examine the effects of nutrition on urine biochemistry and (ii) compare the two different measurement methods (laboratory and commercial strip). This means it is desired to bring a new direction to the literature. Methods: The study involved 42 women aged 20-30 from Turkey and examined the urinary excretion of calcium, vitamin C (smoker and non-smoker), sodium, and magnesium based on nutritional status. The collected urine samples were applied onto commercial urine strips, and the resulting color changes were recorded by smartphone; at the same time, it was sent to the laboratory for comparative analysis. The obtained data were used in regression and correlation statistical analysis. All statistical analyzes were performed using IBM SPSS 28.0. Results: While evaluating the regression analysis results in which the excretion due to nutrition was examined, each nutritional level was compared to the restricted intake. ANOVA sig values <.001, t values 1.96 <, in all metabolites (calcium, vitamin C, sodium, magnesium) evaluations. The following rates (R2 values) were obtained restricted/optimal nutrition in calcium, vitamin C, sodium, and magnesium: .636, .575, .386, and .209 respectively; restricted/high nutrition in calcium, vitamin C (non-smoker), vitamin C (smoker), sodium, magnesium: .442, .308, .482,.413 and .337 respectively; restricted/supplement in calcium, vitamin C, magnesium: .273, .698 and .799. Calcium and magnesium strips correlated strongly with lab results, correlation coefficients are .679 and .59 respectively. Sodium and creatinine strips correlated very strongly with lab results, correlation coefficients are .876 and .884 respectively. Conclusion: The study revealed that nutrition significantly affected urine excretion levels for calcium, vitamin C, sodium, and magnesium. Additionally, the results showed that urine strips had a correlation with laboratory results indicating their usefulness for pre-diagnosis purposes.Öğe Design of electrospun hydrophobically modified polyacrylic acid hydrogel nanofibers and their application for removal of ciprofloxacin(Springer, 2025) İlyasoğlu, Gülmire; Abdullah, Turdimuhammad; Okay, Oğuz; Koyuncu, İsmailThe global water scarcity crisis has been exacerbated by the increasing demand for clean water and water pollution caused by the persistent release of pharmaceuticals such as ciprofloxasin, into water systems. The biodegradation and adsorption potential of CIP is crucial for its elimination in wastewater treatment systems. However conventional methods in wastewater treatment plant (WWTP) often struggle to efficiently eliminate of CIP from water due to its chemically stability and nonbiodegradability. Many researchers observed that CIP was not biodegraded even after 48 days in municipal WWTP, therefor no CIP removal occurred. The objective of this study was to investigate adsorption potential of CIP using a designed electrospun nanofiber. Within the scope of this purpose, we prepared electrospun acrylic acid (AAc)-based hydrogels modified with n-hexadecyl acrylate (C16A) for the first time and evaluated their efficacy in removing CIP from water. Our results show that the desired fiber size and surface smoothness can be obtained in the electrospun hydrogel containing 35 mol% of C16A. As a result, the AAc-based hydrogel nanofiber containing 35 mol% C16A exhibited superior adsorption properties. The adsorption efficiency of the hydrogel for CIP removal from aqueous medium was as high as 98% under equilibrium conditions. The adsorption process was found to follow the pseudo-second-order model, which suggests chemisorption as the dominant mechanism. Isothermal analysis showed that the adsorption fit well with the Langmuir model, suggesting single layer adsorption on a uniform surface. These results highlight the potential of AAc-based hydrogels for the sustainable removal of pharmaceuticals from wastewater, addressing a critical need in environmental contaminant management.Öğe Commentary on “Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants”(2024) Azizoğlu, Mustafa; Klyuev, Sergey; Çakmak, MehmetCommentary on “Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants”Öğe Extraction, characterization, and biocompatibility evaluation of type i collagen from chicken feet skin(Springer nature, 2025) Zourazema, Sevda; Zendeh, Zahra; Aksun, Elif Tuğçe; Görgün, Büşra; Güzel, Fatma Doğan; Çeçen, BerivanThe study focused on extracting type I collagen, a protein derived from chicken feet skin, for applications in the biomedical and cosmetic industries. The research thoroughly explored the extraction methodology and characterization techniques and assessed the biocompatibility of the collagen. Acid extraction yielded substantial amounts of type I collagen with an efficiency of 11.35%. The characterization process involved various analyses, including FTIR, SDS-PAGE, western blot, and SEM imaging, to evaluate purity, structural integrity, and morphology. In vitro testing confirmed the biocompatibility of the extracted collagen, indicating its potential as a natural polymer for medical studies. The collagen extracted from chicken feet skin demonstrated significant bioactivity, positioning it as a promising polymer for tissue engineering, wound healing, and cosmetic applications. This study underlines the importance of developing biocompatible biomaterials and provides valuable insights into a sustainable source of collagen from animal by-products.
