Ambient pressure dried graphene oxide-silica composite aerogels as pharmaceutical nanocarriers

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / GSA-3718-2022
dc.contributor.authorSalihi, Elif Çalışkan
dc.contributor.authorZarrabi, Ali
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorGürboğa, Merve
dc.contributor.authorHasan Niari Niar, Shalaleh
dc.contributor.authorÖzakpınar, Özlem Bingöl
dc.contributor.authorWang, Jiabin
dc.contributor.authorDaştan, Havva
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorŠiller, Lidija
dc.date.accessioned2025-06-10T13:20:24Z
dc.date.available2025-06-10T13:20:24Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractResearch on the production of graphene, its derivatives and composites has been enhanced in the past two decades. Graphene is well known for its exceptional physicochemical properties including extensive surface area, good biocompatibility, high loading capacity, and functionalization capability which make it an ideal candidate for drug delivery systems. When compared to the other nanomaterials, aerogels are relatively new materials characterized by their unparalleled porosities and extensive surface areas. The ability to carry drugs is crucial in drug delivery systems, and the large surface area of graphene coupled with the high porosity of aerogels presents a significant potential for use in this domain. In this study, graphene oxide-silica composite aerogel nanostructures were synthesized firstly, using the sol-gel method and ambient pressure drying technique which offer advantages in terms of both time and cost efficiency. Then, the formulation was also fabricated in the functionalized forms with sodium dodecyl sulfate, polyvinylpyrrolidone and ethylenediaminetetraacetic acid. Different physicochemical characteristics of these new materials were investigated using SEM/EDS, XRD, Raman spectroscopy, FTIR spectroscopy, TGA and DLS techniques. Drug loading tests were done using curcumin and methylene blue, while the biocompatibility of the nanocarriers was assessed through cell viability assay. Results of different tests confirmed the successful fabrication of the aerogels with different functionalizations, which had encapsulation capacity ranged between 20–90% and high biocompatibility after exposing with cells. Based on these promising results, this study confirms that aerogel-based platforms produced have potential to be used as nanocarriers for drug delivery systems. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
dc.identifier.citationSalihi, E. Ç., Zarrabi, A., Zarepour, A., Gürboğa, M., Hasan Niari Niar, S., Özakpınar, Ö. B., ... & Šiller, L. (2025). Ambient pressure dried graphene oxide-silica composite aerogels as pharmaceutical nanocarriers. Journal of Sol-Gel Science and Technology, 113(2), 548-558.
dc.identifier.doi10.1007/s10971-024-06624-1
dc.identifier.endpage558
dc.identifier.issn09280707
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage548
dc.identifier.urihttp://dx.doi.org/10.1007/s10971-024-06624-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7303
dc.identifier.volume113
dc.identifier.wosWOS:001368868500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDrug Carrier
dc.subjectAerogel
dc.subjectGraphene Oxide
dc.subjectGreen Chemistry
dc.subjectNanomaterial
dc.titleAmbient pressure dried graphene oxide-silica composite aerogels as pharmaceutical nanocarriers
dc.typeArticle

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