Evaluation of anticancer effects of carboplatin-gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR light

dc.authoridGökçe Erdemir / 0000-0002-6476-2421en_US
dc.authorscopusidGökçe Erdemir / 57207566355
dc.authorwosidGökçe Erdemir / AAS-4648-2021
dc.contributor.authorDanışman Kalındemirtaş, Ferdane
dc.contributor.authorAfşin Kariper, İshak
dc.contributor.authorErdemir, Gökçe
dc.contributor.authorSert, Esra
dc.contributor.authorErdem Kuruca, Serap
dc.date.accessioned2022-06-28T07:44:06Z
dc.date.available2022-06-28T07:44:06Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractCarboplatin (CP), a platinum analog, is one of the most widely used chemotherapeutic agents in the treatment of colorectal cancer. Although platinum-based drugs are quite efective in anticancer treatments, their use in a wide spectrum and efective treatment possibilities are limited due to their systemic side efects and drug resistance development. In recent years, studies have focused on increasing the therapeutic efcacy of platinum-based drugs with drug delivery systems. Gelatin, a protein, obtained by the hydrolysis of collagen, is a biocompatible and biodegradable material that can be used in nano drug delivery systems. In this study, CP-loaded gelatin-based NPs (CP-NPs) were exposed to IR light in diferent temperatures at 30, 35, 40, 45, and 50 °C and characterized by FESEM-EDX, FTIR, UV–Vis, DLS. Accordingly, we synthesized gelatin-based CP-NPs of diferent sizes between 10–290 nm by exposure to IR. We found that CP-NPs-50, 16 nm nano-sized, obtained at 50 °C had the most cytotoxicity and was 2.2 times more efective than the free drug in HCT 116 colon cancer cells. Moreover, we showed that the cytotoxicity of CP-NPs-50 in normal HUVEC cells was lower. Additionally, we demonstrated that CP-NPs enhanced apoptotic activity while not developing MDR1-related resistance in colon cancer cells. In this study, for the frst time drug loaded gelatin-based nanoparticles were synthesized in diferent sizes with a newly self-assembly method by exposing them to infrared light at diferent temperatures and their anticancer efects were evaluated subsequently.en_US
dc.identifier.citationDanışman-Kalındemirtaş F, Kariper İA, Erdemir G, Sert E, Erdem-Kuruca S. Evaluation of anticancer effects of carboplatin-gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR light. Sci Rep. 2022 Jun 23;12(1):10686. doi: 10.1038/s41598-022-15051-7. PMID: 35739313; PMCID: PMC9226150.en_US
dc.identifier.doi10.1038/s41598-022-15051-7en_US
dc.identifier.issue1en_US
dc.identifier.pmid9226150en_US
dc.identifier.scopus2-s2.0-85132687774en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://doi.org/10.1038/s41598-022-15051-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2950
dc.identifier.volume12en_US
dc.identifier.wosWOS:000816731400012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdemir, Gökçe
dc.language.isoenen_US
dc.relation.ispartofNature Publishing Groupen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of anticancer effects of carboplatin-gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR lighten_US
dc.typeReporten_US

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