Modification of flame etched carbon-fiber microelectrode (FE-CFME) by single walled carbon nanotube/pyreneacetic acid (SWCNT/PAA) nanocomposite for sensitive and selective detection of dopamine

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dc.authorscopusidGhodrat Mahmoudi / 15765751200
dc.authorwosidGhodrat Mahmoudi / AAB-6892-2022
dc.contributor.authorAlizadeh, Vali
dc.contributor.authorMahmoudi, Ghodrat
dc.contributor.authorHosseinifard, Mojtaba
dc.contributor.authorJamali Moghadam, Ahmad
dc.contributor.authorServati Gargari, Masoumeh
dc.date.accessioned2025-06-05T08:32:56Z
dc.date.available2025-06-05T08:32:56Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractAn inexpensive, simple and fast methode of sensor construction as well as negligible sensor surface fouling, along with the high sensitivity and selectivity has always been a challenge in the fabrication of electrochemical sensors. In this study, to achieve this goal, carbon fiber microelectrode (CFME) was pretreated by applying fast flame etching and then simply modifed by pyrene acetic acid (PAA) decorated single walled carbon nanotube (SWCNT) nanocomposite for highly sensitive and selective dopamine (DA) detection. The results show that, although the CFME became active upon flame etching due to introduces nanometer-scale roughness features on it, surface modification by SWCNT-PAA further increases its sensitivity due to synergistic effects. Attaching PAA onto SWCNTs can effectively inhibit the π-stacking of the SWCNTs to prevent their agglomeration and offer a large surface area of electrode, as well as enhancing the diffusion of positively charged DA by its anionic carboxylate moieties. This is the first report on applying PAA/SWCNT nanocomposite for surface modification of flame etched carbon fiber microelectrode (FE-CFME). The surface morphology of the Bare-CFME, FE-CFME, and FE-CFME/SWCNT-PAA electrodes were evaluated using Field-emission scanning electron microscopy (FE-SEM), being correlated with the electrochemical characteristics observed by cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) techniques. As expected, the fabricated sensor showed improved electrochemical response with high sensitivity and selectivity. Under optimum conditions, this sensor exhibited high performance toward DA determination with good linearity in a broad linear range of 0.5 to 22 μM with the detection limit of 12.9 nM, and excellent reproducibility and repeatability. The practical applicability of the fabricated sensor has been successfully tested for the determination of DA in human serum and injection ampoule samples with recovery rates ranging from 98 % to 105 % and relative standard deviations below 3.1 %. © 2025 Elsevier B.V.
dc.description.sponsorshipThe support of this work by research grants from the University of Garmsar Research Council is gratefully acknowledged.
dc.identifier.citationAlizadeh, V., Mahmoudi, G., Hosseinifard, M., Moghadam, A. J., & Gargari, M. S. (2025). Modification of flame etched carbon-fiber microelectrode (FE-CFME) by single walled carbon nanotube/pyreneacetic acid (SWCNT/PAA) nanocomposite for sensitive and selective detection of dopamine. Journal of Electroanalytical Chemistry, 119199.
dc.identifier.doi10.1016/j.jelechem.2025.119199
dc.identifier.issn15726657
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.jelechem.2025.119199
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7297
dc.identifier.volume991
dc.identifier.wosWOS:001497938400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorMahmoudi, Ghodrat
dc.institutionauthoridGhodrat Mahmoudi / 0000-0002-4846-5283
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Electroanalytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbone Fiber Microelectrode
dc.subjectPyreneacetic Acid
dc.subjectSWCNTs
dc.titleModification of flame etched carbon-fiber microelectrode (FE-CFME) by single walled carbon nanotube/pyreneacetic acid (SWCNT/PAA) nanocomposite for sensitive and selective detection of dopamine
dc.typeArticle

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