Crocin suppresses inflammatory response in LPS-induced acute lung injury (ALI) via regulation of HMGB1/TLR4 inflammation pathway

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dc.authorwosidAli Tuğrul Akın / AAX-6342-2021
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorAkın, Ali Tuğrul
dc.contributor.authorKaymak, Emin
dc.contributor.authorVarinli, Saban
dc.contributor.authorToluk, Ayşe
dc.date.accessioned2025-04-18T10:33:06Z
dc.date.available2025-04-18T10:33:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: The most significant pathogen hypothesized to be causing the formation of Acute lung injury (ALI) in sepsis is thought to be lipopolysaccharide (LPS), a key endotoxin component of gram-negative bacteria. The main objective of this study is to determine possible anti-inflammatory effects of crocin (CRO) which has many biological properties such as anti-inflammatory, antioxidant, and anti-apoptotic in LPS-induced ALI. Material and Methods: 40 Wistar albino rats were divided into four groups: Control (no treatment), CRO (given 50 mg/kg crocin for 9 days), LPS (given 30 mg/kg LPS at 9th day), LPS+CRO (given 50 mg/kg crocin for 9 days and 30 mg/kg LPS at 9th day). After experimental, rats were sacrificed and lungs were extracted. Histological examinations were performed in the lung tissue and the changes in the HMGB1 and TLR4 expressions were determined via immunohistochemical staining. Results: Hemorrhage, HMGB1 and TLR4 expressions significantly increased in the LPS group. However, CRO administrations exerted a strong protective effect on the lungs in terms of these parameters in LPS+CRO group. Conclusion: According to our results, we suggest that CRO can be considered as a protective agent against LPS induced ALI via inhibition of HMGB1/TLR4 pathway-mediated inflammatory response.
dc.identifier.citationCeylan, T., Akın, A., Kaymak, E., Varinli, Ş., & Toluk, A. (2024). Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway. Journal of Basic and Clinical Health Sciences, 8(2), 271-278.
dc.identifier.doi10.30621/jbachs.1233245
dc.identifier.endpage278
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue2
dc.identifier.startpage271
dc.identifier.urihttp://dx.doi.org/10.30621/jbachs.1233245
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7118
dc.identifier.volume8
dc.identifier.wosWOS:001262739800007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkın, Ali Tuğrul
dc.institutionauthoridAli Tuğrul Akın / 0000-0002-1408-8571
dc.language.isoen
dc.publisherDokuz Eylül University institute of health sciences
dc.relation.ispartofJournal of basic and clinical health sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute Lung Injury
dc.subjectCrocin
dc.subjectInflammation
dc.subjectLipopolysaccharide
dc.titleCrocin suppresses inflammatory response in LPS-induced acute lung injury (ALI) via regulation of HMGB1/TLR4 inflammation pathway
dc.typeArticle

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