Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

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dc.authoridEzgi Paslı Uysalol / 0000-0001-9357-4588
dc.authoridCengiz Bayram / 0000-0003-2153-0628
dc.authoridNihal Özdemir / 0000-0002-3204-4353
dc.authoridSibel Akpınar Tekgündüz / 0000-0003-4937-1681
dc.authoridGönül Aydoğan / 0000-0002-3805-531X
dc.authoridAli Ayçiçek / 0000-0001-8951-4750
dc.authorscopusidNihal Özdemir / 57208780173
dc.authorwosidNihal Özdemir / AAO-9962-2020
dc.contributor.authorUysalol, Ezgi Paslı
dc.contributor.authorBayram, Cengiz
dc.contributor.authorÖzdemir, Nihal
dc.contributor.authorTekgündüz, Sibel Akpınar
dc.contributor.authorAydoğan, Gönül
dc.contributor.authorAyçiçek, Ali
dc.date.accessioned2025-04-18T09:30:05Z
dc.date.available2025-04-18T09:30:05Z
dc.date.issued12.09.2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Acute lymphoblastic leukemia (ALL) is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 15–18 years who were followed up in our center. Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed Results: The majority of patients were male. The median age of patients was 16 (range 15–17.9) years. About 36% and 74% of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32% of patients were stratified in the high-risk group. BCR/ABL t (9;22) positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58%. Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates.
dc.identifier.citationUYSALOL, E. P., BAYRAM, C., ÖZDEMIR, N., TEKGUNDUZ, S. A., AYDOĞAN, G., AYCICEK, A. (2023). Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience. Çocuk Dergisi , 23(3), 63 - 67. doi.org/10.26650/jchild.2023.1341346
dc.identifier.doi10.26650/jchild.2023.1341346
dc.identifier.endpage67
dc.identifier.issn1302-9940
dc.identifier.issue3
dc.identifier.startpage63
dc.identifier.trdizinid1261803
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1261803/adolescent-acute-lymphoblastic-leukemia-a-retrospective-single-center-experience
dc.identifier.urihttps://doi.org/10.26650/jchild.2023.1341346
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6806
dc.identifier.volume23
dc.identifier.wosWOS:001318931600009
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÖzdemir, Nihal
dc.institutionauthoridNihal Özdemir / 0000-0002-3204-4353
dc.language.isoen
dc.publisherİstanbul Üniversitesi
dc.relation.ispartofÇocuk Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadolescent
dc.subjectleukemia
dc.subjectsurvival
dc.titleAdolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience
dc.title.alternativeAdolesan Akut Lenfoblastik Lösemileri: Geriye Dönük Tek Merkez Deneyimi
dc.typeArticle

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