Effects of keratin6/16 heterodimer on diabetic wound healing treatment with topical metformin

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dc.authoridFatma Kübra Tombultürk /0000-0002-4358-2309
dc.authorscopusidFatma Kübra Tombultürk /56748052500
dc.authorwosidFatma Kübra Tombultürk /L-3969-2018
dc.contributor.authorTombultürk ,Fatma Kübra
dc.date.accessioned2025-04-17T06:14:28Z
dc.date.available2025-04-17T06:14:28Z
dc.date.issued30 Nisan 2024
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Programı
dc.description.abstractDiabetes is an important public health problem, and it is well known that healing processes are impaired in diabetic wounds as one of its complications. Keratins are structural proteins found in skin cells and play a vital role in wound healing and skin integrity. While there is increasing interest in the anti-inflammatory properties of metformin, a drug commonly used for diabetes, its potential effect on wound healing and keratins is not yet fully understood. In this context, it was aimed to evaluate how metformin administration affects keratin 6 and keratin 16 expression at both mRNA and protein levels. In this study conducted on diabetic rats, the effects of topically applied metformin on keratins in wound healing were investigated. Then, protein and mRNA expression levels of keratin 6 and keratin 16 in treated wounds were compared with untreated wounds using reverse transcription polymerase chain reaction and immunohistochemistry methods. The results of the study are likely to detail changes in the expression levels of keratin 6 and keratin 16 after metformin administration. This information will shed light on how metformin affects the molecular mechanisms involved in wound healing, particularly concerning these important structural proteins. Understanding these changes may provide insight into potential therapeutic approaches to improve diabetic wound healing. By elucidating the effect of metformin on keratin expression, the study may contribute to the development of targeted therapies aimed at improving the healing process in diabetic wounds.
dc.identifier.citationTombultürk, F. K. (2024). Effects of keratin6/16 heterodimer on diabetic wound healing treatment with topical metformin. Frontiers in Life Sciences and Related Technologies, 5(1), 65-73. https://doi.org/10.51753/flsrt.1399275
dc.identifier.doi10.51753/flsrt.1399275
dc.identifier.endpage73
dc.identifier.issue1
dc.identifier.startpage65
dc.identifier.trdizinid1232899
dc.identifier.urihttps://doi.org/10.51753/flsrt.1399275
dc.identifier.urihttps://dergipark.org.tr/tr/pub/flsrt/issue/84365/1399275
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6089
dc.identifier.volume5
dc.indekslendigikaynakSobiad
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorTombultürk , Fatma Kübra
dc.institutionauthoridFatma Kübra Tombultürk /0000-0002-4358-2309
dc.language.isoen
dc.publisherİbrahim İlker ÖZYİĞİT
dc.relation.ispartofFrontiers in Life Sciences and Related Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes mellitus
dc.subjectdiabetic wound model
dc.subjectkeratin
dc.subjectmetformin
dc.subjectK6/16
dc.titleEffects of keratin6/16 heterodimer on diabetic wound healing treatment with topical metformin
dc.typeArticle

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