Association of the Naples Prognostic Score with Long-Term Adverse Events in Chronic Limb-Threatening Ischemia After Below-the-Knee Endovascular Revascularization

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dc.authorscopusidİsmail Gürbak / 55934799100
dc.contributor.authorDerviş, Emir
dc.contributor.authorHakgör, Aykun
dc.contributor.authorGöksu, Muhammed Mert
dc.contributor.authorYakut, İdris
dc.contributor.authorKonte, Hasan Can
dc.contributor.authorGürbak, İsmail
dc.contributor.authorKalkan, Ali Kemal
dc.contributor.authorPusuroğlu, Hamdi
dc.contributor.authorYalçın, Ahmet Arif
dc.contributor.authorErtürk, Mehmet
dc.date.accessioned2025-06-03T12:52:00Z
dc.date.available2025-06-03T12:52:00Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives: Chronic limb-threatening ischemia (CLTI) is the most severe manifestation of peripheral artery disease (PAD) and is associated with high morbidity and mortality. The Naples prognostic score (NPS), a composite marker incorporating serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), has shown prognostic value in various cardiovascular conditions. This study aimed to evaluate the prognostic significance of the NPS in predicting all-cause mortality and any kind of amputation in patients with CLTI undergoing endovascular treatment (EVT) for below-the-knee (BTK) lesions. Methods: In this retrospective analysis, 191 patients diagnosed with CLTI and treated with EVT for BTK lesions between 2017 and 2023 were stratified into three groups based on the NPS: low (0–1), intermediate (2), and high (3–4). The primary endpoint was all-cause mortality, while the secondary endpoint was any kind of amputation. Results: A higher NPS was significantly associated with increased all-cause mortality (hazard ratio: 3.66; 95% confidence interval: 1.72–7.78; p < 0.001), while no significant association was observed between the NPS and major amputation. Independent predictors of mortality included a high NPS, reduced left ventricular ejection fraction, and impaired renal function. Conclusions: The NPS is an independent predictor of long-term mortality in CLTI patients undergoing EVT for BTK lesions. © 2024 by the authors.
dc.identifier.citationDervis, E., Hakgor, A., Goksu, M. M., Yakut, I., Konte, H. C., Panc, C., ... & Erturk, M. (2024). Association of the Naples Prognostic Score with Long-Term Adverse Events in Chronic Limb-Threatening Ischemia After Below-the-Knee Endovascular Revascularization. Diagnostics, 14(23), 2627.
dc.identifier.doi10.3390/diagnostics14232627
dc.identifier.issn20754418
dc.identifier.issue23
dc.identifier.pmid39682536
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.3390/diagnostics14232627
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7276
dc.identifier.volume14
dc.identifier.wosWOS:001377328400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGürbak, İsmail
dc.institutionauthoridİsmail Gürbak / 0000-0001-8466-4354
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdverse Events
dc.subjectChronic Limb-threatening Ischemia
dc.subjectMortality
dc.subjectNaples Prognostic Score
dc.subjectPeripheral Arterial Disease
dc.titleAssociation of the Naples Prognostic Score with Long-Term Adverse Events in Chronic Limb-Threatening Ischemia After Below-the-Knee Endovascular Revascularization
dc.typeArticle

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