Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway

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dc.authoridTayfun Ceylan / 0000-0002-0917-0378
dc.authoridAli Akın / 0000-0002-1408-8571
dc.authoridEmin Kaymak / 0000-0002-3818-2693
dc.authoridŞaban Varinli / 0000-0003-0621-5726
dc.authoridAyşe Toluk / 0000-0003-1787-505X
dc.authorscopusidAli Akın / 57196939064
dc.authorwosidAli Akın / AAX-6342-2021
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorAkın, Ali
dc.contributor.authorKaymak, Emin
dc.contributor.authorVarinli, Şaban
dc.contributor.authorToluk, Ayşe
dc.date.accessioned2025-04-18T08:45:33Z
dc.date.available2025-04-18T08:45:33Z
dc.date.issued31 Mayıs 2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground and Purpose: The most significant pathogen hypothesized to be causing the formation of Acute lung injury (ALI) in sepsis is thought to be lipopolysaccharide (LPS), a key endotoxin component of gram-negative bacteria. The main objective of this study is to determine possible anti-inflammatory effects of crocin (CRO) which has many biological properties such as anti-inflammatory, antioxidant, and anti-apoptotic in LPS-induced ALI. Methods: 40 Wistar albino rats were divided into four groups: Control (no treatment), CRO (given 50 mg/kg crocin for 9 days), LPS (given 30 mg/kg LPS at 9th day), LPS+CRO (given 50 mg/kg crocin for 9 days and 30 mg/kg LPS at 9th day). After experimental, rats were sacrificed and lungs were extracted. Histological examinations were performed in the lung tissue and the changes in the HMGB1 and TLR4 expressions were determined via immunohistochemical staining. Results and Conclusion: Hemorrhage, mononuclear cell infiltration and HMGB1 and TLR4 expressions significantly increased in the LPS group. However, CRO administrations exerted a strong protective effect on the lungs in terms of these parameters in LPS+CRO group. According to our results, we suggest that CRO can be considered as a protective agent against LPS induced ALI via inhibition of HMGB1/TLR4 pathway-mediated inflammatory response.
dc.identifier.citationCeylan, T., Akın, A., Kaymak, E., Varinli, Ş., et al. (2024). Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway. Journal of Basic and Clinical Health Sciences, 8(2), 271-278. https://doi.org/10.30621/jbachs.1233245
dc.identifier.doi10.30621/jbachs.1233245
dc.identifier.endpage278
dc.identifier.issue2
dc.identifier.startpage271
dc.identifier.trdizinid1274300
dc.identifier.urihttps://doi.org/10.30621/jbachs.1233245
dc.identifier.urihttps://dergipark.org.tr/en/pub/jbachs/issue/84913/1233245
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6609
dc.identifier.volume8
dc.identifier.wosWOS:001262739800007
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAkın, Ali
dc.institutionauthoridAli Akın / 0000-0002-1408-8571
dc.language.isoen
dc.publisherDokuz Eylul University
dc.relation.ispartofJournal Of Basic And Clinical Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute lung injury
dc.subjectcrocin
dc.subjectinflammation
dc.subjectlipopolysaccharide.
dc.titleCrocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway
dc.typeArticle

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