Neuroprotective effects of dexpanthenol on rabbit spinal cord ischemia/reperfusion injury model

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dc.authoridBora Gürer / 0000-0003-1500-6184en_US
dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / K-1177-2012en_US
dc.contributor.authorGülmez, Ahmet
dc.contributor.authorKuru Bektaşoğlu, Pınar
dc.contributor.authorTönge, Çağhan
dc.contributor.authorYaprak, Ahmet
dc.contributor.authorTürkoğlu, Erhan
dc.contributor.authorÖnder, Evrim
dc.contributor.authorİmge Ergüder, Berrin
dc.contributor.authorSargon, Mustafa
dc.contributor.authorGürer, Bora
dc.contributor.authorKertmen, Hayri
dc.date.accessioned2022-08-11T13:44:02Z
dc.date.available2022-08-11T13:44:02Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Dexpanthenol (DXP) reportedly protects tissues against oxidative damage in various inflammation models. This study aimed to evaluate its effects on oxidative stress, inflammation, apoptosis, and neurological recovery in an experimental rabbit spinal cord ischemia/reperfusion injury (SCIRI) model. Methods: Rabbits were randomized into five groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (vehicle), group 4 (methylprednisolone, 30 mg/kg), and group 5 (DXP, 500 mg/kg). The control group underwent laparotomy only, whereas other groups were subjected to spinal cord ischemia by aortic occlusion (just caudal to the two renal arteries) for 20 min. After 24 h, a modified Tarlov scale was employed to record neurological examination results. Malondialdehyde and caspase-3 levels and catalase and myeloperoxidase activities were analyzed in tissue and serum samples. Xanthine oxidase activity was measured in the serum. Histopathological and ultrastructural evaluations were also performed on the spinal cord. Results: After SCIRI, serum and tissue malondialdehyde and caspase-3 levels and myeloperoxidase activity and serum xanthine oxidase activity were increased (p <0.05-0.001). However, serum and tissue catalase activity decreased significantly (p <0.001). DXP treatment was associated with lower malondialdehyde and caspase-3 levels and reduced myeloperoxidase and xanthine oxidase activities but increased catalase activity (p <0.05-0.001). Furthermore, DXP was associated with better histopathological, ultrastructural, and neurological outcome scores. Conclusion: This study was the first to evaluate antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects of DXP on SCIRI. Further experimental and clinical investigations are warranted to confirm that DXP can be administered to treat SCIRI.en_US
dc.identifier.citationGülmez A, Bektaşoğlu PK, Tonge C, Yaprak A, Türkoğlu ME, Önder E, Ergüder Bİ, Sargon MF, Gürer B, Kertmen H. Neuroprotective Effects of Dexpanthenol on Rabbit Spinal Cord Ischemia/Reperfusion Injury Model. World Neurosurg. 2022 Aug 7:S1878-8750(22)01065-8. doi: 10.1016/j.wneu.2022.07.109. Epub ahead of print. PMID: 35948219.en_US
dc.identifier.doi10.1016/j.wneu.2022.07.109en_US
dc.identifier.issn1878-8750en_US
dc.identifier.pmid35948219en_US
dc.identifier.scopus2-s2.0-85137641942en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1016/j.wneu.2022.07.109
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3086
dc.identifier.wosWOS:000886037000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürer, Bora
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntiapoptoticen_US
dc.subjectAntioxidantsen_US
dc.subjectDexpanthenolen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectNeuroprotectionen_US
dc.subjectSpinal Corden_US
dc.titleNeuroprotective effects of dexpanthenol on rabbit spinal cord ischemia/reperfusion injury modelen_US
dc.typeArticleen_US

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