Assessment of Diagnostic Value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses

Basit Öğe Kaydı
dc.authorscopusidGülcan Sağlam / 56006708800
dc.authorwosidGülcan Sağlam /
dc.contributor.authorKılıç, Derya
dc.contributor.authorYetimalar, Mehmet Hakan
dc.contributor.authorKöseoğlu, Mehmet
dc.contributor.authorSağlam, Gülcan
dc.date.accessioned2025-04-18T07:59:42Z
dc.date.available2025-04-18T07:59:42Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: Human epididymis protein 4 (HE4) is a novel biomarker for ovarian cancers. The aim of this study is to assess the usefulness and efficacy of HE4, in comparison with CA-125 in the differential diagnosis of malignant and benign gynecological diseases in women with adnexal masses. Materials and Methods: 85 patients diagnosed with adnexial mass who were operated at a tertiary referral center between the years of 2012 and 2013 were included in the study. Demographic data, physical examination, results of the laboratory tests, imaging, and pathology were recorded from all subjects. Blood samples were collected before surgery for the evaluation of HE4 and CA-125 levels. Patients were divided into 4 groups according to their histopathologic diagnosis: benign (n:58), malignant (n:17), borderline (n:5) and metastatic (n:5) and serum CA-125 and HE4 levels were compared considering menopausal status. Results: Using 35 U/mL as the cut-off value, CA-125 had a sensitivity of 82.4%, spesificity of 67.2%, a negative predictive value of 92.9%, and a positive predictive value of %42.4%. For the same sensitivity level, specificity was 87.9%, negative predictive value was 94.4%, and the positive predictive value was 66.7% for HE4. Receiver operator characteristic (ROC) area under the curve was higher in both the premenopausal and postmenopausal group for the HE4 curve. Accordingly, sensitivity at set specificity of 90% was 82.4%, and 70.6% for 95% of specificity and 41.1% for 98%. Same sensitivity values for CA-125 were 47.1%, 35.3% and 23.5%, respectively. Conclusion: According to our study, especially in the premenopausal period, HE4 shows higher sensitivity and specificity values than CA-125.
dc.identifier.citationKılıç, D., Yetimalar, H., Sağlam, G., Köseoğlu, M. (2020). Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses. Pamukkale Medical Journal, 13(2), 403-413. https://doi.org/10.31362/patd.712419
dc.identifier.doi10.31362/patd.712419
dc.identifier.endpage413
dc.identifier.issn13099833
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85163087583
dc.identifier.scopusqualityQ4
dc.identifier.startpage403
dc.identifier.urihttp://dx.doi.org/10.31362/patd.712419
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6507
dc.identifier.volume13
dc.indekslendigikaynakScopus
dc.institutionauthorSağlam, Gülcan
dc.institutionauthoridGülcan Sağlam / 0000-0002-7540-673X
dc.language.isoen
dc.publisherPamukkale University
dc.relation.ispartofPamukkale Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdnexal Mass
dc.subjectOvarian Cancer
dc.subjectCA-125
dc.subjectHE4
dc.titleAssessment of Diagnostic Value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses
dc.title.alternativeAdneksiyel kitlesi olan kadınlarda ‘Human Epididimis Faktör (HE4)’ün diagnostik değerinin belirlenmesi
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Bölümü Makale Koleksiyonu