Preliminary study for the development of potent hydrogels for local drug delivery applications

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dc.authoridEce Özcan Bülbül / 0000-0001-7112-923Xen_US
dc.authorscopusidEce Özcan Bülbül / 57211920637
dc.authorwosidEce Özcan Bülbül / ACE-7724-2022
dc.contributor.authorÖzcan Bülbül, Ece
dc.contributor.authorSaıfaka, Panoraıa
dc.contributor.authorOkur Üstündağ, Neslihan
dc.date.accessioned2021-09-13T12:16:04Z
dc.date.available2021-09-13T12:16:04Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümüen_US
dc.description.abstractCurrently, design and development of formulations for the oral cavity and local application is a rather challenging process since the components should be non-irritant and provide relief. Hydrogels-based drug delivery systems have been proposed as suitable candidates for oral mucosal (eg, buccal, sublingual, palatal, gingival) and local (dermal) drug delivery (eg, wound dressings). Herein, the hydrogels were prepared by Carbopol 934, Sodium carboxymethyl cellulose as well as their combination blends to develop efficient hydrogels with tunable activities. The hydrogels were characterized in terms of tensile testing, and physicochemical properties (pH, clarity). Fourier-Transformed Infrared Spectroscopy (FT-IR) was used to evaluate any possible interactions between the components or any newly developed by-products which can lead to toxicity. The F2/F5 formulation, pH (5.86±0.084), viscosity (13305±1209), firmness (39.92±0.77), consistency (356.27±9.01), cohesiveness (-28.58±0.81), and work of cohesion (-231.31±15.02) values were found to be the most suitable formulation. According to the results and the use of biocompatible ingredients, the prepared hydrogels present promising characteristics being suitable candidates for mouth application. Future studies will involve the loading of active molecules and studying their properties.en_US
dc.identifier.citationÖzcan Bülbül, E. , Siafaka, P. , Mutlu, G. & Üstündağ Okur, N. (2021). Preliminary study for the development of potent hydrogels for local drug delivery applications . Journal of Pharmaceutical Technology , 2 (1) , 65-71 . DOI: 10.37662/jpt.2021.9en_US
dc.identifier.doi10.37662/jpt.2021.9en_US
dc.identifier.endpage71en_US
dc.identifier.issn2717-7904en_US
dc.identifier.issue1en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.37662/jpt.2021.9
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2048
dc.identifier.volume2en_US
dc.institutionauthorÖzcan Bülbül, Ece
dc.language.isoenen_US
dc.publisherDergiParken_US
dc.relation.echttps://doi.org/10.37662/jpt.2021.9
dc.relation.ispartofJournal of Pharmaceutical Technologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbopolen_US
dc.subjectCarboxymethyl Celluloseen_US
dc.subjectHydrogelsen_US
dc.subjectLocal Drugen_US
dc.subjectMechanical Activityen_US
dc.titlePreliminary study for the development of potent hydrogels for local drug delivery applicationsen_US
dc.typeArticleen_US

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