Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions

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dc.authoridNecla Değer /0000-0001-7239-3331
dc.authoridMeryem Sayan /0000-0002-9068-1094
dc.authoridAli Akın /0000-0002-1408-8571
dc.authoridTayfun Ceylan /0000-0002-0917-0378
dc.authoridMurat Ünsal /0000-0001-8234-6571
dc.authoridDerya Karabulut /0000-0003-2067-6174
dc.authoridMehmet Kara /0000-0003-0071-3740
dc.authorscopusidAli Akın /57196939064
dc.authorwosidAli Akın /AAX-6342-2021
dc.contributor.authorYıldırım, Ayşegül Burçin
dc.contributor.authorDeğer, Necla
dc.contributor.authorSayan, Meryem
dc.contributor.authorAkın, Ali
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKaymak, Emin
dc.contributor.authorKara, Mehmet
dc.contributor.authorÜnsal, Murat
dc.date.accessioned2025-04-17T07:49:53Z
dc.date.available2025-04-17T07:49:53Z
dc.date.issued30 Kasım 2023
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractThis study aimed to determine whether thymoquinone has any protective effects on renal tissue after an isoproterenol-induced myocardial infarction (MI). Experimental groups were formed as 4 groups (n=8). Control group (C). Thymoquinone group (THQ), 20 mg/kg single dose intragastric (i.g.) daily for seven days. Isoproterenol group (ISO) was administered 100 mg/kg intraperitoneally in two doses on days 7 and 8 of the experiment. Thymoquinone+Isoproterenol group (THQ+ISO), THQ 20 mg/kg i.g. was administered once a day for seven days. In addition, two doses of ISO 100 mg/kg i.p. were administered on the seventh and eighth days. Kidney tissues were evaluated histopathologically. Kidney tissues were evaluated histopathologically. Tumour necrosis factor alpha(TNF-α) and alpha Smooth Muscle Actin(α-SMA) immunoreactivity density changes were determined by immunohistochemistry. Glutathione(GST), Glutathione S-transferases(GSTs) and Interleukin-6(IL-6) levels were evaluated by ELISA method. Isoproterenol injection caused severe histopathological changes on kidney tissue. Also TNF-α and α-SMA levels were found to be higher in groups where ISO was administered. THQ could be effective on kidney tissue to partially correct these histopathological damages, by decreasing fibrosis and inflammation. This study shows that treatment with THQ is effective in preventing kidney damage caused by ISO-induced MI. We think that THQ as a supplementary food will be effective to prevent kidney damage.
dc.identifier.citationYıldırım, A. B., Değer, N., Sayan, M., Akın, A., Ceylan, T., Kaymak, E., ... & Karabulut, D. (2023). Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions. Experimental and Applied Medical Science, 4(2), 515-525.
dc.identifier.doi10.46871/eams.1359212
dc.identifier.endpage525
dc.identifier.issn2757-847X
dc.identifier.issue2
dc.identifier.startpage515
dc.identifier.urihttps://doi.org/10.46871/eams.1359212
dc.identifier.urihttps://dergipark.org.tr/tr/pub/eams/issue/80626/1359212
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6134
dc.identifier.volume4
dc.institutionauthorAkın, Ali
dc.institutionauthoridAli Akın /0000-0002-1408-8571
dc.language.isoen
dc.publisherGaziantep İslam Bilim ve Teknoloji Üniversitesi
dc.relation.ispartofExperimental and Applied Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDil ve konuşma terapisti
dc.subjectdisfaji
dc.subjectyatak başı yutma değerlendirmesi
dc.subjectyutma terapisi
dc.titleInvestigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions
dc.typeArticle

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