Chemical composition and antimicrobial activity of essential oils obtained from inula germanica l.

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dc.authorscopusidMeltem Güleç / 57284570200
dc.authorwosidMeltem Güleç / M-4510-2018
dc.contributor.authorGüleç, Meltem
dc.contributor.authorYazıcı-Tütüniş, Seçil
dc.contributor.authorİşçan, Gökalp
dc.contributor.authorDemirci, Betül
dc.contributor.authorTan, Emir
dc.contributor.authorMiski, Mahmut
dc.contributor.authorTan, Nur
dc.date.accessioned2025-06-18T13:32:57Z
dc.date.available2025-06-18T13:32:57Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
dc.description.abstractThe genus Inula (Asteraceae), consisting of over 100 species predominantly found in Asia, Europe, and Africa, is recognized for its antimicrobial properties. This study explores the chemical composition and antimicrobial activity of essential oils obtained from the aerial parts of Inula germanica L. through conventional (T) and modified (M1, M2) hydrodistillation methods. Using gas chromatography and gas chromatography-mass spectrometry, the conventional method (T) yielded alpha-bisabolol (30.1%) and 12-carboxyeudesma-3,11(13)-diene (14.9%) as major compounds. The modified method fraction M1 enriched monoterpenes such as trans-verbenol (9.5%), 1,8-cineole (9.5%), and cis-chrysanthenyl acetate (9.3%), whereas M2 was characterized by higher levels of sesquiterpenes like 12-carboxyeudesma-3,11(13)-diene (24.3%) and alpha-bisabolol (11.7%). The essential oils exhibited moderate to weak antimicrobial activity against tested bacterial and Candida strains, with minimum inhibitory concentrations (MICs) ranging from 125 to 2000 mu g/mL. Among all studied samples, M1 showed the best antimicrobial activity against Candida strains in the MIC range of 125-500 mu g/mL.
dc.identifier.citationGüleç, M., YAZICI TÜTÜNİŞ, S., İşcan, G., Demirci, B., Tan, E., Miski, M., & Tan, N. (2024). Chemical Composition and Antimicrobial Activity of Essential Oils Obtained from Inula germanica L. Records of Natural Products, 18(6).
dc.identifier.doi10.25135/rnp.24.11.3368
dc.identifier.endpage628
dc.identifier.issn1307-6167
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85214266546
dc.identifier.scopusqualityQ2
dc.identifier.startpage618
dc.identifier.urihttp://dx.doi.org/10.25135/rnp.24.11.3368
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7325
dc.identifier.volume18
dc.identifier.wosWOS:001385687300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGüleç, Meltem
dc.institutionauthoridMeltem Güleç / 0000-0002-3291-4304
dc.language.isoen
dc.publisherACG publications
dc.relation.ispartofRecords of natural products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEssential Oils
dc.subjectHydrodistillation Methods
dc.subjectInula
dc.titleChemical composition and antimicrobial activity of essential oils obtained from inula germanica l.
dc.typeArticle

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