Cancer stem cells : root of the evil

dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834
dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidDidem Karakaş Zeybek / L-6682-2018
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorKarakaş Zeybek, Didem
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:01:36Z
dc.date.available2020-08-30T20:01:36Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.descriptionErkisa Genel, Merve ( isu author)
dc.descriptionKarakas Zeybek, Didem (isu author)
dc.descriptionUlukaya, Engin ( isu author)
dc.description.abstractCancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors (less than 0.1%), these cells determine the fate of cancer patients because of their roles in poor prognoses. Accumulating evidence has shown that CSCs are the major responsible cell population in tumor development, growth, metastasis, and therapy resistance. The self-renewal and differentiation capacity of CSCs contribute to the initiation and maintenance of tumor growth. Several reports indicate that CSCs share numerous molecular characteristics with mesenchymal cells, so CSCs are accepted as leading players in metastasis. In addition, these cells possess a higher intrinsic resistance to chemotherapies and radiotherapies than bulk cancer cells. Therefore, therapeutic approaches in recent years have focused on effectively targeting CSCs. Here, we have reviewed the current literature on the resistant mechanisms of CSCs, their roles in metastasis, and the roles of non-coding RNAs in the regulation of aggressive CSC characteristics and novel therapy approaches against CSCs. © 2019 Begell House, Inc.en_US
dc.identifier.citationErkisa, M., Karakas, D., & Ulukaya, E. (2019). Cancer Stem Cells: Root of the Evil. Critical Reviews™ in Oncogenesis, 24(1).en_US
dc.identifier.doi10.1615/CritRevOncog.2019029512en_US
dc.identifier.endpage87en_US
dc.identifier.issn0893-9675en_US
dc.identifier.issue1en_US
dc.identifier.pmid31679222en_US
dc.identifier.scopus2-s2.0-85064138271en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1615/CritRevOncog.2019029512
dc.identifier.urihttps://hdl.handle.net/20.500.12713/316
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorKarakaş Zeybek, Didemen_US
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.publisherBegell House Inc.en_US
dc.relation.ispartofCritical Reviews in Oncogenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Stem Cellsen_US
dc.subjectMetastasisen_US
dc.subjectNon-Coding Rnasen_US
dc.subjectTherapy Resistanceen_US
dc.titleCancer stem cells : root of the evilen_US
dc.typeArticleen_US

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