Modeling subarachnoid hemorrhage in rabbits: Investigating drugs

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dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / JIJ-1874-2023
dc.contributor.authorGürer, Bora
dc.date.accessioned2025-04-18T10:10:26Z
dc.date.available2025-04-18T10:10:26Z
dc.date.issued2022
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractThe leading causes of poor outcomes after subarachnoid hemorrhage include cerebral vasospasm and delayed cerebral ischemia. An imbalance between vasoconstrictors and vasodilators, neuronal mechanisms that regulate vascular tone, and endothelial proliferation contribute to the pathology after subarachnoid hemorrhage. Subarachnoid hemorrhage-induced vasospasm is a point of interest for researchers. Rabbits become the most suitable alternative species of choice in cerebral vasospasm research. Compared to bigger animals, such as monkeys, pigs, and dogs, rabbits are easy to handle, inexpensive, and docile in nature. Moreover, the rabbit size is adequate for angiography. To induce SAH in rabbits, various models had been introduced: • Blood injection into the cisterna magna • Blood injection into the prepontine cistern • Suprasellar cistern-shunting model • Puncturing middle cerebral artery and superior sagittal sinus This study aimed to summarize current methods of subarachnoid hemorrhage in rabbits. © 2023 Elsevier Inc. All rights reserved.
dc.identifier.citationGürer, B. (2023). Modeling subarachnoid hemorrhage in rabbits: Investigating drugs. In Handbook of Animal Models in Neurological Disorders (pp. 631-640). Academic Press.
dc.identifier.doi10.1016/B978-0-323-89833-1.00047-1
dc.identifier.endpage640
dc.identifier.isbn978-032389833-1, 978-032389886-7
dc.identifier.scopus2-s2.0-85199139628
dc.identifier.startpage631
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6977
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGürer, Bora
dc.institutionauthoridBora Gürer / 0000-0003-1500-6184
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofHandbook of Animal Models in Neurological Disorders
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimal Model
dc.subjectBlood İnjection
dc.subjectCerebral Vasospasm
dc.subjectDelayed Cerebral İschemia
dc.subjectSubarachnoid Hemorrhage
dc.subjectRabbit
dc.titleModeling subarachnoid hemorrhage in rabbits: Investigating drugs
dc.typeBook Chapter

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