Üstünova, S.Kılıç, A.Bulut, H.Gürel-Gürevin, E.Eriş, A.H.Meral, I.2022-04-062022-04-062022ERİŞ, A. H., ÜSTÜNOVA, S., KILIÇ, A., Bulut, H., Gurel-Gurevin, E., & MERAL, İ. (2022). Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone.0277-2248https://doi.org/10.1080/02772248.2022.2051509https://hdl.handle.net/20.500.12713/2610The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 ± 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress. © 2022 Informa UK Limited, trading as Taylor & Francis Group.eninfo:eu-repo/semantics/closedAccess900 MHz EMFCognitive FunctionsHippocampusOxidative StressThymoquinoneArticleWOS:0007692516000012-s2.0-85126664646Q410.1080/02772248.2022.2051509Q3