Ersahan, ŞeydaÖzçelik, FatihŞirin, Dursun AliHepsenoğlu, Yelda ErdemÖzçelik, İlbey KayraTopbaş, Celalettin2022-12-082022-12-082022Ersahan, S., Ozcelik, F., Sirin, D. A., Hepsenoglu, Y. E., Ozcelik, I. K., & Topbas, C. (2022). Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?. Odontology, 1-11.1618-12471618-1255http://dx.doi.org/10.1007/s10266-022-00767-9https://hdl.handle.net/20.500.12713/3428To investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n=80), periodontitis (P) group (n= 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on The Abscess Score (AS), as those having at least 1 tooth with AP and severity of PAI 3-4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-alpha levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-alpha was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis.eninfo:eu-repo/semantics/closedAccessApical PeriodontitisChronic PeriodontitisMid Regional ProadrenomedullinIL-12TNF-AlphaArticleWOS:0008864505000012-s2.0-85142229733Q210.1007/s10266-022-00767-9Q1