Andaç, Ahmet Cenk2021-01-122021-01-122020Andac, C. A. Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity.1307-6175https://www.doi.org/10.25135/acg.oc.86.20.10.1853https://hdl.handle.net/20.500.12713/1312Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1 H,3H ) dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater cytotoxic effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).eninfo:eu-repo/semantics/openAccess1-(3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-prop-1-yl)pyrimidine-2,4(1 H,3H)-dioneMicrowave synthesisNMR; IC50Phenothiazine DerivativesArticle134175183WOS:0006041281000042-s2.0-85098686290N/A10.25135/acg.oc.86.20.10.1853Q4416696