Göçmen, Ayşe YeşimDağlıoğlu, Yusuf KenanKapusuz, ZelihaÖzkırış Özkırış, MahmutGence, Muzaffer2024-05-192024-05-1920182149-71092149-6498https://doi.org/10.32448/entupdates.458996https://search.trdizin.gov.tr/yayin/detay/390293https://hdl.handle.net/20.500.12713/4067Objectives: We aimed to look into potential associations betweenspecific biomarkers and trauma to Cranial Nerve VII (CNVII) in a rabbitmodel, focusing on whether endocrine studies have potential as biomarkers in this context.Methods: 30 adult New Zealand rabbits with intact facial muscleswere used for the research. Each animal underwent identical surgeryby the same surgeon. The facial nerve divisions were exposed by incising below the level of the mandible. After dissection of the skin andsubcutaneous layers, the buccal division of CNVII was located with thenerve stimulator and microscopic dissection and a section of nerve10mm long was excised in each case from the buccal branch of CNVII.Blood samples were drawn 8 weeks and 12 weeks after nerve injuryhad been surgically induced. The samples from day 1, week 4 andweek 8 were tested for the following levels: Testosterone, oestrogen,progesterone, free T3 and T4, Cancer antigen 19-9 (Ca19-9), folate,TPSA, FPSA, FSH, LH, CA15.3, CAE, AFP and prolactin.Results: The levels of free T3 and T4 as well as testosterone, weredown at 4th week, but at 8 weeks each had increased. Ca19-9 levelswere also above the baseline. At 4 weeks, whilst oestrogen had markedly risen, progesterone had fallen. The statistical significance of thechange in levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA was evaluated. For the group of animals with inducedparalysis, the association between the lesion and testosterone, oestrogen, progesterone, free T3 and T4, Ca19-9, and folate levels werestrong and at the level of statistical significance.Conclusion: There were statistically significant alterations in the serum levels of free T3 and T4, testosterone, oestrogen, progesteroneand FPSA at the 4 and 8 week intervals post surgically-induced CNVII injury. It is likely that rabbit pathophysiology resembles humanpathophysiology in nervous injury, hence these six biomarkers may beof value in managing trauma or idiopathic degeneration of CNVII inhumans. The authors hope this study will pave the way for future research in this areaeninfo:eu-repo/semantics/openAccessArticle82889210.32448/entupdates.458996390293