Aydın, M.Ergönül, O.Azap, A.Bilgin, H.Aydın, G.Çavuş, S. A.Demiroğlu, Y. Z.Alışkan, H. E.Memikoğlu, O.Menekşe, S.Kaya, S.Demir, N. A.Karaoğlan, I.Başaran, S.Hatipoğlu, C.Erdinç, S.Yılmaz, E.Tümtürk, A.Tezer, Y.Demirkaya, H.Çakar, S. E.Keşke, S.Tekin, S.Yardımcı, C.Karakoç, Zehra ÇağlaErgen, P.Azap, O.Mülazimoğlu, L.Ural, O.Can, F.Akalın, H.2020-08-302020-08-302018Aydin, M., Ergonul, O., Azap, A., Bilgin, H., Aydin, G., Cavus, S. A., … Stud, H.-R. I. (2018). Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections. JOURNAL OF HOSPITAL INFECTION, 98(3), 260–263. https://doi.org/10.1016/j.jhin.2017.11.0140195-67011532-2939https://doi.org/10.1016/j.jhin.2017.11.014https://hdl.handle.net/20.500.12713/815This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessBloodstreamGram-NegativeHealth CareColistin MicArticle98326026329248504WOS:0004263167000112-s2.0-85044363955Q110.1016/j.jhin.2017.11.014Q1