Hepokur, CeylanKariper, İshak AfşinMısır, SemaAy, Ebru NurTunoğlu, ServetErsez, Mediha SüleymanoğluZeybek, ÜmitKuruca, Serap ErdemYaylım, İlhan2020-08-302020-08-302019Hepokur, C., Kariper, I. A., Misir, S., Ay, E., Tunoglu, S., Ersez, M. S., … Yaylim, I. (2019). Silver nanoparticle/capecitabine for breast cancer cell treatment. TOXICOLOGY IN VITRO, 61. https://doi.org/10.1016/j.tiv.2019.1046000887-2333https://doi.org/10.1016/j.tiv.2019.104600https://hdl.handle.net/20.500.12713/514This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.eninfo:eu-repo/semantics/closedAccessBreast Cancer (Mcf-7)CapecitabineSilver NanoparticlesApoptosisArticle6131302208WOS:0004972518000442-s2.0-85068898097Q210.1016/j.tiv.2019.104600Q2